Effect of Multimorbidity on Fragility Fractures in Community-Dwelling Older Adults: Shimane CoHRE Study

Garu, A; Yano, Shozo; Sheik, Abdullah Md; Yu, Aorigele; Okuyama, Kenta; Takeda, Mitsunobu; Kohno, Kunie; Yamasaki, Masayuki; Isomura, Minoru; Nabika, Toru; Nagai, Atsushi

doi:10.3390/jcm10153225

Cited by 13 publications

(7 citation statements)

References 50 publications

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“…Furthermore, anti-epileptic and steroid use may be involved in bone fragility among patients with rheumatoid arthritis and epilepsy. Therefore, together with other studies [ 30 - 32 ], the results of our study through multivariate regression analysis showed that patients using steroids and anti-epileptics are at a higher risk of vertebral fragility fractures.…”

Section: Discussionsupporting

confidence: 81%

Proportion of Hidden Vertebral Fractures Among Egyptian Males With Fragility Hip Fractures in the Emergency Room of Ain Shams University Hospitals

Abbas,

Allam,

Sweed

et al. 2023

Cureus

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Background Fragility fractures are linked to significant costs for society as well as significant pain and suffering, disability, and even death. It is well-recognized that osteoporosis-related fragility fractures raise the risk of subsequent fragility fractures. One of the most frequent osteoporotic fractures brought on by low bone mineral density and other risk factors is vertebral fractures. Considering that most vertebral fractures are asymptomatic and not clinically identified, proactive screening could stop additional impairment. Objective The current study aims to determine the prevalence and risk factors of hidden vertebral fractures in Egyptian males who have fragility hip fractures. Patients and methods A cross-sectional case-control study examining the correlation of risk factors between cases (fragility hip fracture and vertebral fractures) and a control group (fragility hip fracture without vertebral fracture) was carried out from September 2020 to September 2021 on patients visiting the orthopedic emergency department of a university hospital in Cairo, Egypt. Males who presented to the emergency room (ER) with fragility hip fractures and were 40 years of age or older met our inclusion criteria. For every patient who presented with a fragility hip fracture, standard lateral and anteroposterior radiographs of the dorso-lumbar spine were taken. Results A total of 43,935 patients visited the orthopedic emergency room (ER) throughout the study period; 13,034 of those patients were men, accounting for 29.7% of all orthopedic ER visits. Our inclusion criteria for fragility hip fractures were met by 132 male participants. The screening lumbosacral plain X-rays identified 27 (20.5%) of the 132 patients as having concomitant vertebral fractures in addition to the fragility hip fractures. Concomitant hidden vertebral fractures among Egyptian males with other fragility fractures, particularly fragility hip fractures, are predicted by the number of co-morbid diseases, hypertension, and continuous use of steroids and anti-epileptics. Conclusion Most fragility fractures are avoidable. Because one fragility fracture increases the likelihood of others, early detection is crucial. To prevent complications and mortality, it is important to identify and manage individuals who have a fragility hip fracture as they frequently have concurrent hidden vertebral fractures. Predictive risk factors for fragility vertebral fractures include hypertension, the number of concomitant illnesses, and chronic drugs (anti-epileptics and steroids).

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Section: Discussionsupporting

confidence: 81%

Proportion of Hidden Vertebral Fractures Among Egyptian Males With Fragility Hip Fractures in the Emergency Room of Ain Shams University Hospitals

Abbas,

Allam,

Sweed

et al. 2023

Cureus

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“…Set 1 and Set 2 consisted of 1014 and 841 participants. Both were from Shimane CoHRE Study 20 , 21 , but different arrays were used for genotyping. Set 3 consisted of 1623 participants from Bunkyo Health Study 22 .…”

Section: Resultsmentioning

confidence: 99%

“…Bunkyo Health Study is a prospective cohort study of over 10 years 21 , which recruited older subjects aged 65–84 years living in Bunkyo-Ku, an urban area in Tokyo, Japan. Among the 68 communities in Bunkyo-Ku, we selected 13 communities based on probability proportionate to size sampling.…”

Section: Methodsmentioning

confidence: 99%

A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals

Ito,

Takuwa,

Kakehi

et al. 2024

Commun Biol

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Sarcopenia is a common skeletal muscle disease in older people. Lower limb muscle strength is a good predictive value for sarcopenia; however, little is known about its genetic components. Here, we conducted a genome-wide association study (GWAS) for knee extension strength in a total of 3452 Japanese aged 60 years or older from two independent cohorts. We identified a significant locus, rs10749438 which is an intronic variant in TACC2 (transforming acidic coiled-coil-containing 2) (P = 4.2 × 10−8). TACC2, encoding a cytoskeleton-related protein, is highly expressed in skeletal muscle, and is reported as a target of myotonic dystrophy 1-associated splicing alterations. These suggest that changes in TACC2 expression are associated with variations in muscle strength in older people. The association was consistently observed in young and middle-aged subjects. Our findings would shed light on genetic components of lower limb muscle strength and indicate TACC2 as a potential therapeutic target for sarcopenia.

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“…Set 1 and Set 2 consisted of 1,014 and 841 participants. Both were from Shimane CoHRE Study 19,20 , but different arrays were used for genotyping. Set 3 consisted of 1,623 participants from Bunkyo Health Study 21 .…”

Section: Resultsmentioning

confidence: 99%

“…This cross-sectional study is a part of the cohort study conducted by the Center for Community-based Healthcare Research and Education in Shimane University (Shimane CoHRE Study) 19,20 . Shimane CoHRE Study is an ongoing health examination for the community-dwelling people in Shimane prefecture, Japan.…”

Section: Shimane Cohre Studymentioning

confidence: 99%

A genome-wide association study identifies a locus associated with knee extension strength in older people

Terao

Ito

Takuwa³

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Sarcopenia is a common skeletal muscle disease in older people. Lower limb muscle strength is a good predictive value for sarcopenia; however, little is known about its genetic components. Here, we conducted a genome-wide association study (GWAS) for knee extension strength in a total of 3,452 Japanese aged 60 years or older from two independent cohorts. We identified a significant association in TACC2 (transforming acidic coiled-coil-containing 2) (P = 4.2 × 10− 8). TACC2, encoding a cytoskeleton-related protein, is highly expressed in skeletal muscle, and is reported as a target of myotonic dystrophy 1-associated splicing alterations. These suggest that changes in TACC2 expression are associated with variations in muscle strength in older people. The association was consistently observed in young and middle-aged subjects. Our findings would shed light on genetic components of lower limb muscle strength and indicate TACC2 as a potential therapeutic target for sarcopenia.

show abstract

Effect of Multimorbidity on Fragility Fractures in Community-Dwelling Older Adults: Shimane CoHRE Study

Cited by 13 publications

References 50 publications

Proportion of Hidden Vertebral Fractures Among Egyptian Males With Fragility Hip Fractures in the Emergency Room of Ain Shams University Hospitals

Proportion of Hidden Vertebral Fractures Among Egyptian Males With Fragility Hip Fractures in the Emergency Room of Ain Shams University Hospitals

A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals

A genome-wide association study identifies a locus associated with knee extension strength in older people

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