2011
DOI: 10.1016/j.joen.2011.02.012
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Effect of N-acetylcysteine on Rat Dental Pulp Cells Cultured on Mineral Trioxide Aggregate

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Cited by 37 publications
(29 citation statements)
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“…E xciting opportunities exist for the development of a new generation of dental materials that are functionally modified to act on various biological processes thereby stimulating regenerative events (1,2). Such materials may target tissue injury-associated events using antioxidants (N-acetyl cysteine) (2)(3)(4) or may directly stimulate regeneration by the addition of growth factors (5)(6)(7).…”
mentioning
confidence: 99%
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“…E xciting opportunities exist for the development of a new generation of dental materials that are functionally modified to act on various biological processes thereby stimulating regenerative events (1,2). Such materials may target tissue injury-associated events using antioxidants (N-acetyl cysteine) (2)(3)(4) or may directly stimulate regeneration by the addition of growth factors (5)(6)(7).…”
mentioning
confidence: 99%
“…Such materials may target tissue injury-associated events using antioxidants (N-acetyl cysteine) (2)(3)(4) or may directly stimulate regeneration by the addition of growth factors (5)(6)(7). However, targeting cell nuclear function offers a novel mode of action because acetylation of DNA-associated histone and non-histone proteins influences gene expression and induces various cellular processes (8)(9)(10).…”
mentioning
confidence: 99%
“…MTA has been shown to improve the secretion of IL-1β and IL-8 and does not adversely affect the generation of reactive oxygen species and cell survival (Camargo et al 2009). However, the release of aluminum ions by MTA may have a partial inhibitory effect on pulp stromal cells (Minamikawa et al 2011).…”
Section: Mode Of Action In Pulp Capping and Pulpotomymentioning
confidence: 99%
“…Recently, the biological activities of MTA have been investigated at the cellular level. In vivo studies have shown that MTA allowed cemental regeneration over root-end fillings in dogs 4) and monkeys 5) , whereas in vitro studies reported that osteoblasts 6,7) , periodontal ligament cells 8) , and dental pulp cells 9,10) attached to MTA, which induced proliferation. These findings suggest that MTA stimulates the repair and regeneration of mineralized tissues.…”
Section: Introductionmentioning
confidence: 99%