Tomatoes, also referred to as poor man orange, are a great source of antioxidants; Vitamin K and C, which are beneficial to the health of the human being, play a significant role in processes industries. This review article aims to highlight the uptake of mineral nutrients from foliar fertilization of tomato for its growth and developmental responses of various cells and tissue. It holds several health assistances, including urinary tract infection, skin problems, diabetes, hypertension, and various cancers. Despite several kinds of research conducted on many characteristics of foliar fertilization while many are still unknown. In tomato, foliar fertilization is the most effective method compared to soil nutrient availability, which is low, topsoil dry, and root activity during the reproductive stage is decreased. Foliar fertilization is also successful in increasing the content of the fruit, yield, and the potential for the developmental process. It is anticipated that the foliar fertilizer should be recommended in the integrated tomato production. It provides a link between the treatment of micro and macronutrients and helpful in boosting productivity leading to quality of tomato crop and environment friendly. This review article discusses the effect of various nutrients, methods, and applications on the quality and quantity of tomatoes. In addition, their effects on the vegetative and reproductive stages of tomatoes are also discussed.