In this study, the effect of wood powder and nanoclay particle content on composites’ mechanical behavior made with polyethylene matrix has been investigated. The wood flour as a reinforcer made of wood powder was at levels of 30, 40, and 50 wt.%, and additional reinforcement with nanoclay at 0, 1, 3, and 5 wt.%. Furthermore, to make a composite matrix, high-density polyethylene was used at levels of 70, 60, and 50% by weight. Wood-plastic composite (WPC) specimens were manufactured in injection molding. After preparing the specimens, tensile and bending tests were performed on samples. The mechanical properties such as tensile and flexural strength and flexural modulus were measured. Results showed that nanoclay particle content increases flexural modulus, flexural strength, modulus of elasticity, and tensile strength. The experimental test results show that Young’s moduli increased with the volume of wood flour. The biggest modulus of elasticity was achieved in the samples having 50 wt.% of wood powder. Furthermore, the highest value of tensile strength was achieved at the level of 30 wt.%. The highest flexural strength was for the sample containing 50% wood powder by weight. Additionally, a numerical model was made utilizing the Abaqus software using the finite element method (FEM). Comparing the numerical and experimental results, it was found that they are compatible in the linear-elastic and plastic state of the material. There are no crucial differences between experiment and FEM.