Effect of nanosecond HPM pulses on individual development of Drosophilas: estimation of comparative contribution by microwave and X-ray components

Bolshakov, M. A.; Eltchaninov, A. A.; Klimov, A. I.; Knyazeva, I. R.; Korovin, S. D.; Pegel, I. V.; Rostov, V. V.; Voskresensky, V.V.

doi:10.1109/korus.2001.975182

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“…The last authors have also showed an increase in the number of degenerating tumor cells and tumor cells in a stage of lysis after in vitro exposure to HPMP [Devyatkov et al, 1994]. HPMP exposure ceased the individual development of Drosophila [Bolshakov et al, 2000[Bolshakov et al, , 2001a, inhibited a growth rate of fungus Fusarium sp., and suppressed a level of RNA and DNA synthesis in tumor cells of mastocytoma P-815 [Bolshakov et al, 2000[Bolshakov et al, , 2001b. Natarajan et al [2002] showed that exposure of human cells to HPMP can increase DNA binding activity of NF-kB, which can then transactivate the expression of its target genes and thereby change the chromatin structure.…”

Section: Introductionmentioning

confidence: 99%

Lack of direct DNA damage in human blood leukocytes and lymphocytes after in vitro exposure to high power microwave pulses

Chemeris

Gapeyev

Сирота

et al. 2006

Bioelectromagnetics

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Currently, the potential genotoxicity of high power microwave pulses (HPMP) is not clear. Using the alkaline single cell gel electrophoresis assay, also known as the alkaline comet assay, we studied the effects of HPMP (8.8 GHz, 180 ns pulse width, peak power 65 kW, pulse repetition frequency 50 Hz) on DNA of human whole-blood leukocytes and isolated lymphocytes. The cell suspensions were exposed to HPMP for 40 min in a rectangular waveguide. The average SAR calculated from the temperature kinetics was about 1.6 kW/kg (peak SAR was about 300 MW/kg). The steady-state temperature rise in the 50 microl samples exposed to HPMP was 3.5 +/- 0.1 degrees C. In independent experiments, we did not find any statistically significant DNA damage manifested immediately after in vitro HPMP exposure of human blood leukocytes or lymphocytes or after HPMP exposure of leukocytes subsequently incubated at 37 degrees C for 30 min. Our results indicate that HPMP under the given exposure conditions did not induce DNA strand breaks, alkali-labile sites, and incomplete excision repair sites, which could be detected by the alkaline comet assay.

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Section: Introductionmentioning

confidence: 99%