Effect of natural nanoparticles products on hepato-renal functions in breast carcinoma female rats

Abstract

The aim of this study was to evaluate the effect of natural nano-composite products in combination with doxorubicin chemotherapy treatment on serum biochemical profile in mammary cancer induced in fifty female rats divided as following; control normal n= 10, mammary carcinogenesis Induced group with MNU (50 mg/ kg. b. wt. / I.P dose) n=40 which divided into three subgroups (10 rats in each group): mammary carcinoma non-treated gp, doxorubicin treated group (33 mg /kg. b .wt. / I.P. dose), basic nano-curcumin (35 mg/ kg. b. wt. /oral dose) + doxorubicin treated group and basic nano-brown algae (70 mg /kg. b .wt. / oral dose) + doxorubicin treated group. Blood urea nitrogen (BUN) and serum creatinine level, AST and ALT activities were determined during the course of chemotherapy treatment among different groups. The level of BUN, creatinine and AST activity were more than normal reference range in doxorubicin chemotherapy treatment, basic nano-curcumin and basic nano-brown algae; while the value of serum ALT was reported to be within the normal reference range in case of treatment by using basic nano-curcumin with doxorubicin chemotherapy. In conclusion, the obtained results suggest that, treatment with chemotherapy and basic nano-curcumin in combination improve serum biochemical profile in breast carcinoma induced in rats.