Effect of naturally occurring hydroxychavicol acetate on the cytokine production in T helper cells

Min, Hyun Jung; Nam, Joo Won; Yu, Eun Sun; Hong, Jeong Ho; Seo, Eun Kyoung; Hwang, Eun Sook

doi:10.1016/j.intimp.2009.01.008

Cited by 28 publications

(8 citation statements)

References 33 publications

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“…The dominant components isolated from the rhizomes were galangoisoflavonoid [19], β-sitosterol diglucosyl caprate [20], methyleugenol, p-coumaryl diacetate, 1′-acetoxyeugenol acetate, trans-p-acetoxycinnamyl alcohol, trans-3,4-dimethoxycinnamyl alcohol, p-hydroxybenzaldehyde, p-hydroxycinnamaldehyde, trans-p-coumaryl alcohol, galangin, trans-p-coumaric acid, and galanganol B [21]. The major phytoconstituents which have been isolated from the rhizomes are acetoxychavicol acetate (ACA) and hydroxychavicol acetate (HCA) [22]. Rhizomes are lowest in fat but richest in carbohydrate [23].…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line

Samarghandian

Hadjzadeh

Afshari

et al. 2014

BMC Complement Altern Med

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BackgroundWe investigated the potential of galangal rhizomes to induce cytotoxic and apoptotic effects in the cultured human breast carcinoma cell line, (MCF-7) in compare with the non-malignant (MRC-5) cells.MethodsBoth cells were cultured in DMEM medium and treated with galangal rhizomes for three consecutive days. The percentage of apoptotic cells was determined by flow cytometry using Annexin-V fluorescein isothiocyanate.ResultsThe results showed that the ethanolic extract of galangal rhizomes decreased cell viability in the malignant cells as a concentration- and time- dependent manner. The IC50 values against MCF-7 were determined at 400.0 ± 11.7 and 170.0 ± 5.9 μg/ml after 48 and 72 h respectively. The morphology of MCF-7 cells treated with the ethanolic extract confirmed the cell proliferation assay results. Alpinia galanga induced apoptosis in MCF-7 cells, as determined by flow cytometry.ConclusionsWe concluded that the extract of Alpinia galanga exerts pro-apoptotic effects in a breast cancer-derived cell line and could be considered as a potential chemotherapeutic agent in breast cancer.

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Section: Introductionmentioning

confidence: 99%

Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line

Samarghandian

Hadjzadeh

Afshari

et al. 2014

BMC Complement Altern Med

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“…[18] Isolated chavicol analogues, viz, acetoxychavicol acetate (ACA) and hydroxychavicol acetate (HCA), have been comparably examined, where ACA exhibited potent antioxidant activity, increased cell apoptosis, and decreased cytokine production by T helper cells, whereas HCA suppressed T-bet expression and might act as a beneficial therapeutics for treating inflammatory immune disorders caused by extravagant activation. [19] Joint Care B, a herbal formulation containing A. galanga has shown dose-dependent inhibition of carrageenan-induced paw inflammation and granuloma weight in croton oil-induced granuloma pouch model in rats. [20] Evaluation of anti-inflammatory activity has been done on alcoholic extract of Kaempferia Galanga in rats, which is a plant belonging to the same species.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory activity of root of Alpinia galanga willd

Ghosh¹,

Banerjee²,

Bhattacharyya³

2011

Chron Young Sci

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Objective: The objective of the study is to evaluate the acute and chronic anti-inflammatory activities of root extract of Alpinia galanga in rodents. Materials and Methods: The study was carried out using albino rats of either sex (150-200 g). An extract of the root of A. galanga was prepared using absolute alcohol and distillation in a Soxhlet apparatus. The acute anti-inflammatory effects of this extract were evaluated using carrageenan-, bradykinin-, and 5-HT-induced rat paw edema. The chronic anti-inflammatory effects were evaluated using formaldehyde-induced rat paw edema. Results and Analysis: Inhibition of inflammation was seen to be 32.22% in carrageenan-induced, 37.70% in 5-HT-induced, and 35.21% in bradykinin-induced anti-inflammatory models. In chronic inflammatory model, a progressive inhibition of 34.73% (3 rd day), 37.50% (5 th day), 38.83% (7 th day), 44.66% (9 th day), 49.59% (11 th day), and 55.75% (13 th day) was observed with study compound. The efficacy was comparable with the standard drugs. Conclusion: It can be thus concluded that A. galanga has anti-inflammatory properties and probably acts by blocking histaminic and serotonin pathways. It may be an effective alternative to NASAIDs and corticosteroid in inflammatory disorders.

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“…Senyawa Hydroxychavicol (HC) dari sirih hijau diketahui memiliki aktivitas penghambatan terhadap xantin oksidase (Murata et al 2009) dan juga bersifat antifungi terhadap genus Candida dan Aspergillus dalam uji in vitro (Ali et al 2010). Senyawa yang merupakan turunan HC, yaitu Hydroxychavicol acetate (HCA) memiliki berbagai aktivitas diantaranya sebagai imunomodulator (Min et al 2009), antibakteri (Sharma et al 2009) dan anti penggumpalan darah (Chang et al 2007).…”

Section: Pendahuluanunclassified

Isolasi Bakteri Endofit dari Tanaman Sirih Hijau (<i>Piper betle</i> L.) dan Potensinya sebagai Penghasil Senyawa Antibakteri

2017

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Endophytic bacteria are beneficial microorganisms that interact with host plants without causing disruption or damage to the host. Some studies suggest that certain endophytic bacteria can produce chemical compounds that have an effect on health, especially endophytic bacteria isolated from medicinal plants. Green betel (Piper betle L.) is a medicinal plant that has been used for years and has many benefits. The purposes of this study are to isolating and screening of endophytic bacteria from green betel against four pathogenic bacteria (Staphylococcus aureus, Escherichia coli, Bacillus cereus and Salmonella enteritidis). The number of endophytic bacteria that has been isolated are 14 isolates. Based on the screening results, three isolates of endophytic bacteria have potential activity (characterized by the formation of inhibition zone) against S. aureus. The inhibition zone may indicate that those isolates produce compounds that have antibacterial effects. Those isolates are AS1, BS1 and BS2. The biggest inhibition zone showed by BS1, so it can be concluded that BS1 is the most potential isolate as a novel source of antibacterial compound.

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Effect of naturally occurring hydroxychavicol acetate on the cytokine production in T helper cells

Cited by 28 publications

References 33 publications

Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line

Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line

Anti-inflammatory activity of root of Alpinia galanga willd

Isolasi Bakteri Endofit dari Tanaman Sirih Hijau (<i>Piper betle</i> L.) dan Potensinya sebagai Penghasil Senyawa Antibakteri

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