Effect of near-infrared light exposure on mitochondrial signaling in C2C12 muscle cells

Noninvasive low-level laser therapy for thrombocytopenia

“…However, in contrast to MKs, none of the genes downstream of Pgc1a (26)-Tfam, Drp1, Fis1, or Mff-were up-regulated in BM nucleated cells or LSKs measured in parallel ( fig. S2B), similar to what has been described previously (27), probably owing to diploidy of the cells in contrast to the polyploidy of MKs ( fig. S2C) (28).…”

“…3D and table S1), including mitochondrial transcriptional factor A (Tfam), dynaminrelated protein (Drp1), mitochondrial fission 1 protein (Fis1), and fig. S2A), corroborating the ability of LLL to stimulate Pgc1a in different cell types (27). However, in contrast to MKs, none of the genes downstream of Pgc1a (26)-Tfam, Drp1, Fis1, or Mff-were up-regulated in BM nucleated cells or LSKs measured in parallel ( fig.…”

“…Next, LLL specifically augmented mitochondrial biogenesis in MKs, which has never been shown in other types of cells and is ascribed to a polyploidy of MKs, a unique character of MKs. A previous study demonstrated that near-infrared light exposure increased Pgc1a expression by about 20% in mouse muscle cells, but expression of the downstream mitochondrial component genes (Tfam, Nrf-1, Sirt3,and cytochrome c) was unaltered (27). Likewise, LLL increased Pgc1a transcription in BMs and LSKs, concomitant with no mitochondrial biogenesis or increases in expression of other downstream genes.…”

Can low-level laser therapy (LLLT) associated with an aerobic plus resistance training change the cardiometabolic risk in obese women? A placebo-controlled clinical trial

“…Some body systems like circulatory, musculoskeletal and adipose tissue have chromophores (light-absorbing molecules) that are capable of absorbing photons, for example hemoglobin, myoglobin, cell membranes and mitochondria [27,33]. In fact, we observed in the current study that the LLLT treatment associated with aerobic plus resistance training promoted improvement in cardiometabolic risk factors in obese women, first due to the decrease of visceral fat then for the decrease of inflammatory markers.…”

Desarrollo de un Sistema Terapéutico por Radiación Infrarroja

“…La fototerapia que utiliza específicamente longitudes de onda de luz cercanas al infrarrojo (NIR) (~ 800-950nm), es una modalidad terapéutica que los clínicos utilizan cada vez más como paradigma terapéutico para lesiones y / o trastornos musculo-esqueléticos agudos y crónicos. En concreto, la terapia de luz NIR es actualmente utilizada por los médicos para controlar y / o suprimir el dolor, la fatiga muscular, la osteoartritis, la inflamación y mejorar la reparación y regeneración de las lesiones de tejidos blandos [2][3][4][5][6][7][8]. A pesar de que existen reportes en la literatura del uso de terapia utilizando radiación, existen pocos estudios donde se optimice la longitud de onda en el tratamiento a realizar.…”