Effect of Neonatal Androgenization on Luteinizing Hormone, Follicle-Stimulating Hormone, Prolactin and Testosterone Levels in Male Rats

Moguilevsky, Jaime A.; Scacchi, Pablo; Rubinstein, Lidia

doi:10.1677/joe.0.0740143

Cited by 13 publications

(7 citation statements)

References 4 publications

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“…These results and a previous report [Moguilevsky et at., 1977] indicate that the establishment of sexual dif ferences in the mechanisms of control of FSH is a relevant process that takes place during the differentiation of hypothalamus, and confirm that the devel opment of these mechanisms is directly influenced by the presence of tes tosterone in the first days of life. The fact that neonatal androgenization increased FSH levels in the prepubertal and adult female rats also supports this point of view.…”

Section: Discussionsupporting

confidence: 92%

“…1967;Gorski, 1971], The tonic or male Gn pattern characteristically shows higher levels of plasma and pituitary follicle-stimulating hormone (FSH) and serum prolactin as compared with females [Johnson, 1967[Johnson, , 1971N eill, 1972]. In a previous paper [Moguilevsky et at., 1977], we demonstrated that the administration of testosterone to male rats during the first days of life produces an increase in the FSH and prolactin levels in the adult as compared with untreated males.…”

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confidence: 99%

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Effects of Neonatal Androgenization on Serum Gonadotropin Levels of Prepubertal and Adult Male and Female Rats

Moguilevsky¹,

Scacchi²,

Epstein³

et al. 1978

Neuroendocrinology

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Experiments were designed to study the effect of neonatal androgenization on the FSH and LH levels in prepubertal (16 and 30 days old) and adult (90 days old) male and female rats. Androgenization was performed by injecting the pups with 1 mg of testosterone propionate on the 2nd post-partum day. The results obtained in the female rats showed that androgenization increased FSH levels in rats of 30 days old and 90 days old (adult) without modifying the LH levels. Androgenized rats of 16 days old do not show the very high levels of LH and FSH that were observed in normal rats, which are probably connected with a positive feed-back mechanism of estrogens. The data obtained in males indicates that there were no differences in the serum LH concentrations between controls and androgenized groups of different ages and that the FSH values were significantly higher in the androgenized than in the normal rats during prepubertal and pubertal stages. The conclusion of this study is that the neonatal androgenization produces in the male and female rats a similar pattern of gonadotropins (Gns) modifications: increase in the FSH levels without modifications in the LH concentration. This results gives additional support to the concept that the establishment of sexual differences in the mechanisms of control of FSH is a relevant process during the sexual differentiation of hypothalamus.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Effects of Neonatal Androgenization on Serum Gonadotropin Levels of Prepubertal and Adult Male and Female Rats

Moguilevsky¹,

Scacchi²,

Epstein³

et al. 1978

Neuroendocrinology

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“…In previous papers [8,9] it has been dem onstrated that neonatal androgenization in creases FSH in both male and females rats; these results are confirmed again in this paper. Nevertheless, not only such differences dis appear after castration but also androgenized rats showed lower levels of FSH than the controls in the first few days after gonadectomy.…”

Section: Discussionsupporting

confidence: 90%

“…The tonic or male Gn pattern characteristically shows higher levels of plas ma and pituitary follicle-stimulating hormone (FSH) and serum prolactin [4,5,10]. In pre vious papers [8,9] we demonstrated that the administration of testosterone to male and female rats during the first days of life pro duces an increase in the FSH and prolactin levels in the adult as compared with untreated rats.…”

mentioning

confidence: 97%

Effect of Castration on Serum Gonadotropin Levels in Androgenized Male and Female Rats

Moguilevsky¹,

Faigón²,

Scacchi³

et al. 1979

Neuroendocrinology

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The changes in LH and FSH secretion 12, 18 h and 1, 3, 5, 20 and 30 days following castration in adult rats of both sexes neonatally androgenized were studied. After castration, serum LH concentration rose slowly in the female and rapidly in male rats. Orchidectomy induced an increase of LH that was significantly slower in the androgenized rats than in the controls until 20 days after the postcastration period, reaching similar values at 30 days. In the female rats the increase in the LH levels from 48 h to 30 days after castration was significantly lower in the androgenized than in the control rats. Basal levels of FSH were higher in the androgenized males than in the controls. The concentration of the hormone increased in both groups 12 h after orchidectomy, the basal differences disappearing. These groups of rats showed similar values from 48 h up to 30 days after castration. As in the males, FSH basal levels were higher in androgenized rats than in control female rats and the difference disappeared 12 h after castration. The increase in the FSH concentration postgonadectomy was significantly lower in androgenized rats than in the control rats from 48 h to 20 days. At this time, both groups reach a plateau with similar values. These results indicate that androgenized male and female rats showed, at different times of the postcastration period, lower levels of FSH and LH than the controls and that these differences disappear after 30 days of castration. On the other hand, the differences in the basal levels of FSH concentration between controls and androgenized male and female rats also disappear in the first few hours postgonadectomy.

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“…On the other hand, normal levels of adrenal androgens are only of minor importance for the control of gonadotrophic function (Verjans 8c Eik-Nes 1975) and a dynamic reserve of pituitary LH and FSH appropriate for skeletal age and sex has been demonstrated in adequately glucocorticoid-substituted patients with CAH (Reiter et al 1975;Wentz et al 1976;Klingensmith et al 1976;Cacciari et al 1976). Thus, in female patients with CAH, neonatal exposure to high levels of androgens does not, as in the rat (Pfeiffer 1936;Barraclough 1966;Moguilevsky et al 1977) imprint a pattern of gonadotiophin-release which is permanently different from that seen in normal females.…”

Section: Discussionmentioning

confidence: 91%

Gonadotrophin-Release Upon Intravenous Administration of a Long-Acting Analogue of Luteinizing Hormone-Releasing Hormone in Females With Increased Plasma-Androgens

Vierhapper

Waldhäusl

Nowotny

1979

Acta Endocrinologica

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D-Ser-(TBU)6-EA10-LH-RH, an analogue of luteinizing hormone-releasing hormone (LH-RH) with prolonged action evokes in normal male and female subjects a qualitatively different secretory pattern of LH, as peak levels are reached between 30 and 60 min in males and between 120 and 240 min in females. Females with increased production of adrenal androgens due to congenital adrenal hyperplasia (off substitution therapy; N = 8), idiopathic hirsutism (N = 1) and adrenocortical carcinoma (N = 2) present upon the administration of the LH-RH-analogue with a secretory pattern of LH and FSH which is qualitatively identical with that of normal female subjects, whereas the response of LH in these patients differs from that seen in normal males. Pre-treatment with dexamethasone did not induce any qualitative changes in the secretory response of LH and FSH upon the LH-RH-analogue in patients with increased endogenous production of adrenal androgens. A larger pool and/or a more pronounced de novosynthesis of LH, which apparently is not altered by increased levels of adrenal androgens, may be the cause of the more pronounced and prolonged increase of LH in female subjects following the administration of the LH-RH-analogue. Previous studies about the action of D-Ser-(TBU)C-EA10-LH-RH (König et al. 1975) in normal male (Wiegelmann el al. 1976; Vierhapper et al. 1977) and female (Friedrich et al. 1978; Dericks-Tan et al. 1977) subjects have shown a prolonged response of LH and FSH in comparison to equimolar doses of

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Effect of Neonatal Androgenization on Luteinizing Hormone, Follicle-Stimulating Hormone, Prolactin and Testosterone Levels in Male Rats

Cited by 13 publications

References 4 publications

Effects of Neonatal Androgenization on Serum Gonadotropin Levels of Prepubertal and Adult Male and Female Rats

Effects of Neonatal Androgenization on Serum Gonadotropin Levels of Prepubertal and Adult Male and Female Rats

Effect of Castration on Serum Gonadotropin Levels in Androgenized Male and Female Rats

Gonadotrophin-Release Upon Intravenous Administration of a Long-Acting Analogue of Luteinizing Hormone-Releasing Hormone in Females With Increased Plasma-Androgens

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