Effect of Neonatal Thymectomy, Bursectomy and Thymo-bursectomy on Hæmagglutinin Production in Chickens

Isaković, Katarina; Janković, Branislav D.; Popesković, Ljiljana; Milosević, D

doi:10.1038/200273b0

Cited by 26 publications

(9 citation statements)

References 11 publications

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“…It has been shown by several workers (6)(7)(8)(9)13) that the presence of the bursa in the first few weeks of postembryonic life is essential for the evolution of antibody forming potential in the chicken. In addition, we have demonstrated recently (13) that the impaired antibody res ponse of bursaless chickens can be almost completely restored by bursal homografts.…”

Section: Discussionmentioning

confidence: 99%

“…It seems, however, that burscctomy at hatching does not influence delayed hypersensitive responses (10,11). On the other hand, neonatal thymectomy in chickens, as in mammals, con siderably retards the rejection of skin homografts (12), despite nor mal antibody forming capacity (13). It is, therefore, quite possible that in birds bursa and thymus share roles in the ontogenesis of im mune function (14).…”

mentioning

confidence: 99%

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Experimental Allergic Encephalomyelitis in Thymectomized, Bursectomized and Normal Chickens

Janković

Isvaneskí²

1963

Int Arch Allergy Immunol

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Experimental Allergic Encephalomyelitis in Thymectomized, Bursectomized and Normal Chickens

Janković

Isvaneskí²

1963

Int Arch Allergy Immunol

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“…Despite the wide variation in the levels of circulating in~munoglobulins of surgically bursectomized chicks, these birds have consistently demonstrated deficient primary humoral immune responses but normal secondary responses (Glick et al 1956;Mueller et al 1960;Warner et al 1962;Isakovic et al 1963;Claflin et al 1966;Cooper et al 1966;Cooper er al. 1969;Lerner et al 1971).…”

Section: Discussionmentioning

confidence: 99%

Failure to induce autoimmune disease with neonatal bursectomy in chickens

Mahouy¹,

Holliday²,

Box³

et al. 1974

Can. J. Microbiol.

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To assess the effect of abnormal control of bursa-derived B cell function upon the development of spontaneous autoimmune disease, newly hatched chicks were surgically bursectomized or sham-bursectomized and studied up to 4 months of age. The presence of autoimmune disease was assessed by direct Coombs' test, measurement of antinuclear antibody, total hemoglobin, packed cell volume, plasma bilirubin, red cell survival, and immunofluorescence studies on frozen kidney sections. Despite abnormal immunoglobulin levels detected in bursectomized chickens, no significant differences in terms of autoimmune activity could be demonstrated between the two groups. This suggests that primary B cell control is an unlikely factor in the etiology of autoimmune disease and supports earlier studies which imply that a major factor leading to progressive autoimmune disease is the failure of a normal T cell suppression function.

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“…The effect of thymectomy on the antibody response of the chicken is subject to some controversy. Thym ectomy alone did not impair the antibody response to human gamma globulin [5] and erythrocytes [26] and impaired the response to bovine serum albumin in only a small fraction (6 %) of the animals [22], C o o per et al [15] reported that a significant proportion of thymectomized-irradiated chickens were unable to produce antibodies against Brucella abortus antigen and bovine serum albumin, but no significant difference was noted between the group means.…”

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confidence: 99%

<i>In vitro</i> Studies of Chicken Lymphoid Cells

Alm¹

1971

Int Arch Allergy Immunol

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White leghorn chickens, thymectomized and sublethally X-irradiated at hatching, showed increased titers of serum hemagglutinins to sheep erythrocytes (SRBC). Increased numbers of direct spleen plaque forming cells (PFC) were demonstrated with the Jerne technique using this antigen. Deliberate immunization i.v. with SRBC did not significantly increase the hemagglutinin titers or the numbers of direct or indirect PFCs per spleen. Spleen cells from thymectomized-irradiated chickens (TX) in tissue culture displayed impaired proliferative responses, measured as ³H-thymidine uptake, to phytohemagglutinin (PHA) and allogeneic spleen cells treated with mitomycin C. Also the proliferative response of spleen cells from immunized TX chickens to SRBC appeared deficient.

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Effect of Neonatal Thymectomy, Bursectomy and Thymo-bursectomy on Hæmagglutinin Production in Chickens

Cited by 26 publications

References 11 publications

Experimental Allergic Encephalomyelitis in Thymectomized, Bursectomized and Normal Chickens

Experimental Allergic Encephalomyelitis in Thymectomized, Bursectomized and Normal Chickens

Failure to induce autoimmune disease with neonatal bursectomy in chickens

<i>In vitro</i> Studies of Chicken Lymphoid Cells

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