Effect of nerolidol on cyclophosphamide-induced bone marrow and hematologic toxicity in Swiss albino mice

Iqubal, Ashif; Syed, Mansoor Ali; Haque, Mohammad Mahfuzul; Najmi, Abul Kalam; Ali, Javed; Haque, Syed Ehtaishamul

doi:10.1016/j.exphem.2020.01.007

Cited by 34 publications

(24 citation statements)

References 39 publications

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“…Importantly, it should be noted that the endpoint of oxidative stress, nitrative stress and inflammation always manifest histological aberrations (Tsounapi et al, ; Iqubal et al, ). In our study, we found a marked histological alteration and reduction in gonadal weight, spermatogenesis, sperm count, sperm motility and gonadal hormones which were in accordance with the earlier reports (Anan et al, ; Çeribaşi, Türk, Sönmez, Sakin, & Ateşşahin, ; Golmohammadi et al, ; Potnuri et al, ).…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of nerolidol on cyclophosphamide‐induced gonadal toxicity in Swiss Albino mice: Biochemical‐, histological‐ and immunohistochemical‐based evidences

et al. 2020

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Cyclophosphamide (CP) is commonly used as antineoplastic and immunosuppressant drug with noticeable gonadotoxic profile. Nerolidol (NER) is a sesquiterpene with potent antioxidant and anti‐inflammatory properties. Thus, the present study was designed to explore its possible gonadal protective potential against cyclophosphamide‐induced testicular, epididymal, seminal and spermatozoal toxicities. Animals were divided into five groups: control (normal saline for 14 days), treatment group (NER 200 and 400 mg/kg, p.o) for 14 days along with a single dose of cyclophosphamide (200 mg/kg, i.p) on 7th day, toxic and Per se groups (cyclophosphamide 200 mg/kg i.p) on 7th day and NER 400 mg/kg for 14 days respectively. Animals were sacrificed on the 15 day, and body weight, weight of reproductive organs, testosterone level, sperm count, biochemical parameters, histopathological and immunohistochemical studies were performed in the testes, epididymis and in the serum. CP administration induced oxidative stress, nitrative stress, inflammation, reduced testosterone level, sperm count, increased expression of MPO and caused histological aberrations in the testes, epididymis and seminal vesicles. CP caused reduced sperm count, sperm motility and testosterone level which got reversed upon treatment with nerolidol in a dose‐dependent manner. Nerolidol thus acted as a gonadoprotective molecule and prevented the gonadotoxicity of CP.

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Section: Discussionmentioning

confidence: 99%

Ameliorative effect of nerolidol on cyclophosphamide‐induced gonadal toxicity in Swiss Albino mice: Biochemical‐, histological‐ and immunohistochemical‐based evidences

et al. 2020

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“… 2019 ; Iqubal et al. 2020 ). In the present study, severe damage to bone marrow by CTX was observed in the histopathological lesions.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of Sheng Xue Fang in a cyclophosphamide-induced anaemia mouse model

Dou

Gong

et al. 2021

Pharmaceutical Biology

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Context Sheng Xue Fang (SXF) has been used to treat anaemia for decades with good efficacy. Objective To study the effect and possible mechanism of SXF to restore haematopoietic function. Materials and methods Balb/c mice (10 per/group, half male, half female) were treated with SXF (three dose groups, 8.5, 17, and 22.1 g/kg) by gavage for 14 days, and cyclophosphamide (80 mg/kg) was injected on days 10–12. Only injection of cyclophosphamide (negative control) or physiological saline (blank control) were included as controls. The spleen and femur were processed for histopathology. Active components and the target of SXF were screened. The target was used for gene enrichment and protein-protein interaction (PPI) analysis. Results Red blood cell relative changes in the SXF group (low: −5.50 ± 1.58%; medium: −11.11 ± 4.15%; high: −8.81 ± 2.67%) and relative negative control (26.21 ± 2.51%) significantly increased (all p < 0.01) in female mice. Haemoglobin and red blood cell-specific volume showed the same trend. However, SXF did not have significant effects on male mice. Splenic index in the medium group (4.44 ± 0.46%) relative negative control (3.38 ± 0.10%) significantly improved ( p < 0.01) in female mice. Using network pharmacology, 77 active components and 337 targets were screened from SXF. These targets are closely related to the mitogen-activated protein kinase pathway. Conclusions SXF has good clinical application potential. However, the mechanism requires in-depth research. Our findings are of great significance in anaemia treatment and provide a new perspective for Chinese medicine research.

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“…It is further hypothesized that COVID-19 uses the ACE-2 receptor for invasion into pneumocytes and from there it gets translocated to different organs and also induces pathological events [ 5 ]. Thus, owing to the involvement of ACE-2 receptor, people with coexisting cardiovascular risk are very much susceptible to infection and also, patients with no previous history of cardiac complication are at risk of one or other cardiotoxic events [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

COVID-19 and cardiovascular complications: an update from the underlying mechanism to consequences and possible clinical intervention

Iqubal

Hoda

et al. 2021

Expert Review of Anti-infective Therapy

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Introduction : The novel coronavirus has caused significant mortality worldwide and is primarily associated with severe acute respiratory distress syndrome (ARDS). Apart from ARDS, clinical reports have shown noticeable cardiovascular complications among the patients of COVID-19. Infection from virus, stimulation of cytokine storm, altered immune response, and damage to myocardial tissue are some of the proposed mechanisms of cardiovascular complications in COVID-19. Areas covered : Based on the clinical reports of CVDs among COVID-19 patients, we have discussed the molecular mechanisms involved in cardiovascular pathogenesis, its prevalence, and association with COVID-19, and various available therapeutic modality for the treatment. Expert opinion : Seeing the cardiovascular complications in COVID-19 patients and its association with the existing drug, risk–benefit ratio of treatment paradigm, as well as the level of cardiac injury biomarkers must be monitored regularly. Additionally, a well-designed clinical trial should be conducted where head to head comparison can be made with anti-COVID-19 drugs and cardioprotective anti-inflammatory drugs. Nevertheless, vaccines are the best-suited approach, but until then, sanitization, social distancing, and active lifestyle are the best ways to beat this global pandemic situation.

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Effect of nerolidol on cyclophosphamide-induced bone marrow and hematologic toxicity in Swiss albino mice

Cited by 34 publications

References 39 publications

Ameliorative effect of nerolidol on cyclophosphamide‐induced gonadal toxicity in Swiss Albino mice: Biochemical‐, histological‐ and immunohistochemical‐based evidences

Ameliorative effect of nerolidol on cyclophosphamide‐induced gonadal toxicity in Swiss Albino mice: Biochemical‐, histological‐ and immunohistochemical‐based evidences

Therapeutic effects of Sheng Xue Fang in a cyclophosphamide-induced anaemia mouse model

COVID-19 and cardiovascular complications: an update from the underlying mechanism to consequences and possible clinical intervention

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