Effect of Nifedipine on Dichlorvos-Induced Seizure in Mice

Abstract

Problem statement: Dichlorvos a synthetic organophosphate poisons is the property of insecticide. These toxins as insecticides in agriculture and medicine for animals and the destruction of ectoparasites can be used. Studies have shown that Dichlorvos creation seizure effects in different animals. Nifedipine, dihydropyridine calcium channel blockers, widely used for treatment of cardiovascular diseases. Studies have shown that the calcium channel blockers are anticonvulsant effects in different animal models. The aim of this study was to determine the effect of nifedipine on Dichlorvosinduced seizures in mice. Approach: In this experiment, the animals were received different doses of nifedipine (2.5, 5, 10, 20 and 40 mg kg and highest (p<0.001) had anticonvulsant effects. Conclusion: The anticonvulsant activity of nifedipine suggests that possibly due to antagonistic effect on voltage-dependent calcium channel.

Has Oxidative Stress any Role on Mechanisms of Aminophylline – Induced Seizures? An Animal Study

“…So, aminophylline induced clonic/tonic-clonic seizures in a dose-dependent manner and this is in agreement with earlier reports in this regard. 5,10,19 Though aminophylline has got antioxidant property the present study it was also found that it generate sufficient amount of free radicals.…”

“…3 These repetitive, generalized seizures are commonly fatal and no specific, pharmacologically antagonistic drug is known. 4 In an attempt to evaluate the mechanisms involved in this phenomenon, several studies have been implicated for one or the other mode of action, 5,6 but no clear-cut consensus regarding the toxicodynamics of theophylline-induced seizures has emerged.…”

Anticonvulsant Effect of Diazoxide against Dichlorvos‐Induced Seizures in Mice

“…Exposures to OPs are source of significant quantity of poisonings that affect various organs such as skeletal muscles, GI tract, bladder, secretory glands, CNS, and respiratory systems and create many signs and symptoms such as weakness, glandular secretion, fasciculation, acute pancreatitis, convulsion, respiratory depression, and finally death [ 10 , 11 ]. Centrally mediated seizures and convulsions are one of the toxic signs that happen following poisoning with organophosphorus (OP) anticholinesterase such as Dichlorvos [ 12 , 13 ]. Since treatment of this life-threatening effect of OP compounds is very importants so the aim of this study was to determine the effect of diazoxide (potassium channel opener) on Dichlorvos-induced seizures in mice.…”

Effect of Phenylbutazone on Pentylenetetrazole-Induced Seizure in Mice

“…An innate immune response is mediated by microglia that contributes to the progression of the diseases. Activated microglia produce several proinflammatory and neurotoxic mediators including complement, cytokines, chemokines, acid arashidonic and its metabolites and reactive oxygen and nitrogen species, several of which contribute directly to neuronal injury (Perrone et al, 2010;Mirhadi, 2011). Alterations in the microenvironment such as microglial inflammation and the release of proinflammatory cytokines may affect normal cell proliferation and differentiation, which could cause ectopic neurogenesis, astrogliosis and ectopic synaptic reorganization (Haiju et al, 2009).…”