Effect of Nigella sativa on Testosterone Level in Albino Rats Treated with Doxorubicin

Abstract

Objective: To measure the influence of Nigella sativa on testosterone level of albino rats treated with doxorubicin
 Study Design: Investigational study.
 Place of Study: Animal House, JPMC, Karachi,
 Materials and Methods: This study was accompanied on 3-4 months old, 40 albino rats, in the animal house of BMSI, Anatomy department, Karachi for 5 weeks were taken for this study and distributed into 4 groups, A1, A2, A3 &A4. A1 served as control, A2 receive Doxorubicin 3 mg/kg /week intraperitonealy, A3 receive extract of Nigella sativa 1000mg/kg daily orally along with Doxorubicin 3 mg / kg /week intraperitonealy and A4 receive extract of Nigella sativa 1000mg/kg daily orally. At completion of study, animals were sacrifice and tissues were preserved for staining.
 Time of Study: The time of study was 35 days.
 Results: In A2 serum Testosterone was markedly decreased, i.e 3.093+0.091 ng/ml as compared to A1 though serum levels were extremely substantial raise in A3 when compared with A2. This shows amended role of Nigella sativa on Doxorubicin induced kidney.
 Conclusion: This study reveals that Nigella sativa amended the serum levels of testosterone of doxorubicin induced kidney.

Protective effects of selenium nanoparticles against doxorubicin-induced testicular apoptosis in rats

“…All rats were randomly divided into four groups (n = 8rats/group) as follows: Group I acted as a control and was injected with 0.5 ml of a single intraperitoneal (IP) injection of normal saline daily for four weeks. Group II was used as the Dox-treated group and was administered a single IP injection of Dox (Shaanxi Xinheng Biotech, China) for four weeks at a dose of 3 mg/kg/week prepared in normal saline (Kumar et al, 2016). Group III served as the SeNP-treated group and was administered 0.5 mg/kg SeNPs (Nano-Tech, Cairo, Egypt) by oral gavage daily for four weeks (Asadpour et al, 2020).…”