Effect of Nigella sativa Volatile Oil on Jurkat T Cell Leukemia Polypeptides

Hailat, Nabil; Bataineh, Ziad M.; Lafi, Shawkat Q.; Raweily, E. A.; Aqel, M.; Al-Katib, Mohamad; Hanash, Sam

doi:10.3109/13880209509088141

Cited by 19 publications

(15 citation statements)

References 7 publications

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“…The oil from N.sativa is used in preliminary clinical medicine for cough and bronchial asthma (Vardharajan, 1985). The seeds are considered as carminative stimulant, diuretic, emenagogue, galactagogue and are used in the treatment of mild cases of puerperal fever (Vardharajan, 1985, Hailat, 1995. N.sativa is an annual herb and is widely spread in southern Europe and western Asia, abundantly in Mediterranean region (Vardharajan, 1985).…”

Section: Introductionmentioning

confidence: 99%

“…In India it is found in Punjab, Bihar, Assam and Himachal Pradesh (Vardharajan, 1985). The seeds are trigonous black rugulose tubercular and used as a flavouring agent and for the medicinal purposes (Vardharajan, 1985, Hailat, 1995. In view of its medicinal value the N.sativa was chosen for the extraction of essential oil with an aim to establish its antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi.…”

Section: Introductionmentioning

confidence: 99%

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GC-MS analysis of Nigella sativa seeds and antimicrobial activity of its volatile oil

Gerige

Rao

et al. 2009

Braz. arch. biol. technol.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

GC-MS analysis of Nigella sativa seeds and antimicrobial activity of its volatile oil

Gerige

Rao

et al. 2009

Braz. arch. biol. technol.

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“…7,.8 Recent pharmacological investigations of the seed extract revealed that a wide spectrum of biological activities including anti-inflammatory, antidiabetic, analgesic, antibacterial, antifungal, anti-helmintic, 9 bronchodilatory, 10 hypertensive and immunoprotecting activities. 11 The seeds are believed to have carminative, diuretic, lactogoge, stimulatory and diaphoretic properties and are used in the treatment of bronchial asthma and eczema. [12][13][14][15] The hexane and benzene extracts of its seeds were exhibited 67% and 40% post-coital anti-implantation activity at the dose level of 500 mg kg -1 per day, respectively.…”

Section: Introductionmentioning

confidence: 99%

Novel lipid constituents identified in seeds of Nigella sativa (Linn)

Mehta¹,

Verma²,

Gupta³

2008

J. Braz. Chem. Soc.

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Lipídeos inéditos foram isolados de matéria insaponificável extraída de sementes de Nigella sativa Linn, usando-se n-hexano. O dienoato e os dois monoésteres inéditos foram identificados por técnicas espectrométricas, incluindo IV, RMN de 1 H e 13 C, espectrometria de massas, e análise química. O dienoato (1) foi identificado como metilnonadeca-15, 17-dienoato e os dois monoésteres foram identificados como pentil hexadec-12-enoato (2) e pentil pentadec-11-enoato (3). Ácido linoleico, ácido oléico, b-sitosterol e stigmasterol foram identificados como parte das estruturas dos lipídeos. Todos os compostos mostraram atividade moderada contra Staphylococcus aureus e baixa atividade contra shigella spp e Klebsiella pneumoniae.Novel lipids were isolated from the unsaponifiable matter extracted from seeds of Nigella sativa Linn by using n-hexane. The new dienoate and two monoesters were the new lipids identified by spectral (IR, 1 H-and 13 C-NMR spectra, mass spectrum, elemental analysis) and chemical analysis. The dienoate (1) was identified as methylnonadeca-15,17-dienoate and two monoesters were identified as pentyl hexadec-12-enoate (2) and pentyl pentadec-11-enoate (3). Linoleic acid, oleic acid, b-sitosterol and stigmasterol were identified as part of the lipid structures. All compounds exhibited moderate activity against Staphylococcus aureus and poor activity against shigella spp, and Klebsiella pneumoniae.Keywords: Nigella sativa, seeds, Ranunculaceae, aliphatic esters IntroductionNigella sativa Linn., a plant belonging to the family Ranunculaceae, grows as a small herb and is cultivated throughout India and other tropical regions of the world. 1,2 It is commonly known as black cumin seed and kalaungi in Hindi in India. The seed contains alkaloids nigellidine, 3 nigellimine and nigellicine, 4,5 tannin, steroids a-spinasterol, 6 campesterol, cholesterol, stigmasta-7-en3b-ol, stigmasterol and b-sitosterol, flavonoids of trigillin quercetin-3-glucoside, saponin and nigellone. 7,.8 Recent pharmacological investigations of the seed extract revealed that a wide spectrum of biological activities including anti-inflammatory, antidiabetic, analgesic, antibacterial, antifungal, anti-helmintic, 9 bronchodilatory, 10 hypertensive and immunoprotecting activities. 11 The seeds are believed to have carminative, diuretic, lactogoge, stimulatory and diaphoretic properties and are used in the treatment of bronchial asthma and eczema. [12][13][14][15] The hexane and benzene extracts of its seeds were exhibited 67% and 40% post-coital anti-implantation activity at the dose level of 500 mg kg -1 per day, respectively. 16 The present study reports the isolation and structural elucidation of three new lipids (Figure 1) isolated from seeds of Nigella sativa Linn. Linoleic acid, oleic acid, b-sitosterol and stigmasterol were identified as part of the structures of the new lipids. Results and DiscussionThe novel natural compounds were identified mainly by their 1D ( 1 H and 13 C NMR), 2D ( 1 H-1 H COSY), DEPT and mass spectrometry analy...

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“…Nigela Sativa, has been used as a tonic to promote heath and treatment of various diseases [40]. -11, 2018 in-vitro [41,42].…”

Section: Anti-cancer Activity Of Nigella Sativamentioning

confidence: 99%

Anticancer Herbs for Improving the Quality of Life

2018

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A B S T R A C TIn the world, there are many systems of traditional medicine. Cancer is the major public health burden both in developing and developed countries. Around 50% of existing medicines for cancer treatment have plants origin. Anticancer property of some plant extracts proven to be significantly effective in the treatment of cancer. Many herbs like sadabahar, turmeric, Kalonji, cannabis, garlic, flaxseed contain active components which may be effective in prevention and treatment of many cancers. The present review focuses on the evidence of health benefit of various herbs though recent human and animal studies.

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Effect of Nigella sativa Volatile Oil on Jurkat T Cell Leukemia Polypeptides

Cited by 19 publications

References 7 publications

GC-MS analysis of Nigella sativa seeds and antimicrobial activity of its volatile oil

GC-MS analysis of Nigella sativa seeds and antimicrobial activity of its volatile oil

Novel lipid constituents identified in seeds of Nigella sativa (Linn)

Anticancer Herbs for Improving the Quality of Life

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