Effect of ninjin'yoeito, a <scp>K</scp>ampo (traditional <scp>J</scp>apanese) medicine, on cognitive impairment and depression in patients with <scp>A</scp>lzheimer's disease: 2 years of observation

Kudoh, Chiaki; Arita, Ryutaro; Honda, Masashi; Kishi, Taichi; Komatsu, Yasuhiro; Asou, Hiroaki; Mimura, Masaru

doi:10.1111/psyg.12125

Cited by 61 publications

(76 citation statements)

References 38 publications

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“…The Japanese herbal medicine Ninjin'yoeito (NYT) improves fatigue, loss of appetite, and anemia . Here we report its efficacy for fatigue and apathy in four cases of autistic spectrum disorder (ASD).…”

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confidence: 99%

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Apathy and fatigue in autistic spectrum disorder improved by Japanese herbal medicine: TSUMURA Ninjin'yoeito extract

Sato

2018

Psychiatry Clin Neurosci

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confidence: 99%

“…Both symptoms improved in all cases with no adverse effects. Although the mechanism of improvement of fatigue and apathy by NYT is unclear, NYT is known to improve anemia cognitive impairment and especially inflammation which is associated with apathy and fatigue…”

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confidence: 99%

Apathy and fatigue in autistic spectrum disorder improved by Japanese herbal medicine: TSUMURA Ninjin'yoeito extract

Sato

2018

Psychiatry Clin Neurosci

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“…Fatigue in cancer survivors was improved by ninjin'yoeito [9]. Furthermore, ninjin'yoeito was effective for Alzheimer's disease patients with depression, anorexia, apathy and cognitive dysfunction, which is related to kidney function in kampo medicine [10,11]. This medicine was effective for cough and poor appetite in an elderly patient with lung carcinoma [12].…”

Section: Discussionmentioning

confidence: 99%

Ninjin'yoeito for symptoms of frailty: Successful treatment of three cases

Kimura

Ito

2019

Traditional & Kampo Medicine

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Cases Patient 1 was an 81‐year‐old patient with general fatigue. Patient 2 was a 56‐year‐old patient who felt cold, with general fatigue and dry cough, after operation for lung cancer; and patient 3 was a 55‐year‐old woman with interstitial pneumonia after breast cancer treatment, who reported feeling cold, with general fatigue and a tendency to catch colds. Outcome Patient 1’s cognition and dry skin were improved by changing hachimigan and hochuekkito to ninjin'yoeito; patients 2 and 3 were effectively treated with ninjin'yoeito. The symptoms of these patients were consistent with frailty. In the five viscera theory, symptoms of lumbago, physical weakness, and cognitive decline are caused by impaired kidney function, while digestive problems involve spleen function. Respiratory symptoms and dry skin are signs of disorder in lung function. Improvement of qi deficiency, which causes a feeling of general fatigue, can address all these symptoms. Conclusion Ninjin'yoeito was useful to treat various symptoms of frailty due to age or severe disease.

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“…On the other hand, yokukansan is effective in patients predominantly presenting with "positive symptoms" such as delusions, hallucinations, and agitation. Ninjin'yoeito has been reported to be effective in treating anorexia and apathy in AD patients with frailty [39], and depression [40]. Therefore, ninjin'yoeito may be effective for treating the "negative symptoms".…”

Section: Discussionmentioning

confidence: 99%

The Efficacy and Safety of Yokukansankachimpihange for Treating Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease: An Open-Label Pilot Study

Arita¹,

Yoshino²,

Ohgishi³

et al. 2018

AAD

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Previous clinical trials have demonstrated the efficacy of yokukansan, a traditional Japanese medicine, for the treatment of behavioral and psychological symptoms of dementia (BPSD). However, less evidence is available for the treatment of BPSD with yokukansankachimpihange (YKSCH), which consists of yokukansan and two additional herbal ingredients. The present study was conducted to investigate the efficacy and safety of YKSCH for treating BPSD in patients with Alzheimer's disease (AD). We enrolled outpatients with mild-to-moderate AD who exhibited BPSD and obtained a Neuropsychiatric Inventory (NPI) score of >3 including subscale scores for "agitation", "anxiety", "irritability", and "sleep and night-time behavior change". A daily YKSCH dose of 7.5 g was administered for 12 weeks with concomitant administration of anti-dementia medication. BPSD was evaluated using the NPI at baseline and every 4 weeks during the intervention. We also examined apathy using the Japanese translation of the Apathy Scale, the short version of the Japanese version of the Zarit Caregiver Burden Interview, and the Modified Crichton Rating Scale for Predicting Activities of Daily Living. Cognitive dysfunction was evaluated using the Mini Mental State Examination and the AD Assessment Scale-Cognitive (Japanese version). Five participants were enrolled. The NPI total score tended to decrease between the baseline

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Effect of ninjin'yoeito, a Kampo (traditional Japanese) medicine, on cognitive impairment and depression in patients with Alzheimer's disease: 2 years of observation

Abstract: A 2-year follow-up of patients receiving donepezil and NYT treatment showed an improved cognitive outcome and alleviation of AD-related depression.

Cited by 61 publications

References 38 publications

Apathy and fatigue in autistic spectrum disorder improved by Japanese herbal medicine: TSUMURA Ninjin'yoeito extract

Apathy and fatigue in autistic spectrum disorder improved by Japanese herbal medicine: TSUMURA Ninjin'yoeito extract

Ninjin'yoeito for symptoms of frailty: Successful treatment of three cases

The Efficacy and Safety of Yokukansankachimpihange for Treating Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease: An Open-Label Pilot Study

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