Effect of nociceptin on alcohol intake in alcohol-preferring rats

Ciccocioppo, Roberto; Panocka, Izabela; Polidori, Carlo; Regoli, Doménico; Massi, Maurizio

doi:10.1007/s002130050828

Cited by 125 publications

(119 citation statements)

References 18 publications

Supporting

Mentioning

107

Contrasting

Order By: Relevance

“…Both approaches 'Anti-alcohol' effects of Ro 64-6198 A Kuzmin et al demonstrated that the effects of Ro 646198 are selective for the ADE. The effects of nociceptin (Ciccocioppo et al, 1999(Ciccocioppo et al, , 2004Martin-Fardon et al, 2000;Kuzmin et al, 2003) and Ro 64-6198 (present study) on alcohol intake may be mediated through several neurotransmitter systems. The dopamine (DA) and opioid systems regulating ethanol-related behaviors may be involved.…”

Section: Discussionmentioning

confidence: 60%

“…This peptide also reduced the effects of footshock stress on ethanolseeking behavior (Martin-Fardon et al, 2000). In place conditioning experiments, nociceptin reduced alcoholinduced conditioned place preference and reinstatement of acquired place preference after extinction (Ciccocioppo et al, 1999;Kuzmin et al, 2003). The peptide alone did not affect place preference, suggesting that it is devoid of 'motivational' properties (Devine et al, 1996;Ciccocioppo et al, 1999;Kuzmin et al, 2003).…”

Section: Introductionmentioning

confidence: 93%

“…Several studies have demonstrated that the endogenous nociceptin/opioid receptor-like 1 (ORL-1) receptor system is involved in the rewarding effects of ethanol (Ciccocioppo et al, 1999(Ciccocioppo et al, , 2004Martin-Fardon et al, 2000;Kuzmin et al, 2003). Thus, nociceptin injected intracerebroventricularly (i.c.v.)…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Nociceptin/Orphanin FQ Receptor Agonist Ro 64-6198 Reduces Alcohol Self-Administration and Prevents Relapse-Like Alcohol Drinking

Kuzmin

Kreek

Bakalkin

et al. 2006

Neuropsychopharmacol

View full text Add to dashboard Cite

Effects of the opioid receptor like-1 (ORL-1) receptor agonist Ro 64-6198 (0.1, 0.3, and 1.0 mg/kg intraperitoneally (i.p.)) on operant ethanol self-administration and activation of self-administration by ethanol deprivation were studied in male Wistar rats. Acute administration of Ro 64-6198 caused a dose-dependent reduction of ethanol self-administration. In comparison, the opioid antagonist naltrexone (0.1, 0.3, and 1.0 mg/kg i.p.) inhibited ethanol self-administration at all doses tested. Ethanol deprivation for 10 days significantly increased ethanol self-administration during the first 2 days after deprivation. Daily pretreatment with Ro 64-6198 (0.3 mg/kg) or naltrexone (0.3 mg/kg) during the last 3 days of ethanol deprivation abolished the deprivation-induced increase in ethanol intake. Thus, stimulation of the ORL-1 receptors by Ro 64-6198 reduced the acute reinforcing effects of ethanol and prevented relapse-like behavior in the ethanol-deprivation model in a similar manner as a blockade of opioid receptors by naltrexone. Ro 64-6198 at 0.1 and 0.3 mg/kg doses did not alter self-administration of 0.2% saccharin solution, indicating an apparent selectivity of this compound in modification of ethanol reward. These findings add further support to the idea that Ro 64-6198 and potentially other synthetic ORL-1 receptor agonists are as effective as naltrexone in blocking the actions of ethanol important for its addictive potential in animal experiments, and therefore may have therapeutic value in the treatment of alcoholism. Neuropsychopharmacology (2007) 32, 902-910.

show abstract

Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 93%

See 1 more Smart Citation

The Nociceptin/Orphanin FQ Receptor Agonist Ro 64-6198 Reduces Alcohol Self-Administration and Prevents Relapse-Like Alcohol Drinking

Kuzmin

Kreek

Bakalkin

et al. 2006

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…N/OFQ injections significantly reduced home-cage ethanol intake in the two bottle choice and ethanol-induced conditioned place-preference paradigms (Ciccocioppo et al 1999(Ciccocioppo et al , 2002b). In addition, N/OFQ has been shown to inhibit stress-induced reinstatement of alcoholseeking behaviour in rats trained to self-administer ethanol (Martin-Fardon et al 2000).…”

Section: Introductionmentioning

confidence: 95%

Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats

et al. 2004

Self Cite

View full text Add to dashboard Cite

Rationale-Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the opioid-like orphan receptor NOP, was shown to reduce home-cage ethanol consumption, ethanol-induced conditioned place preference and stress-induced reinstatement of alcohol-seeking behaviour.Objectives-The present study, using genetically selected Marchigian Sardinian alcoholpreferring (msP) rats, was designed to evaluate the effect of this opioid peptide on 10% ethanol and 10% sucrose self-administration, under a fixed-ratio 1 (FR 1) or a progressive-ratio (PR) schedule of reinforcement. Furthermore, using an experimental model of relapse in which rats were trained to lever press for ethanol in the presence of the discriminative stimulus of an orange odour (S + ) and a 1-s cue light (CS + ) or for water in the presence of anise odour (S − ) and 1-s white noise (CS − ), the effect of N/oFQ on cue-induced reinstatement of extinguished ethanol responding was investigated.Correspondence to: Roberto Ciccocioppo, roberto.ciccocioppo@unicam.it. NIH Public AccessAuthor Manuscript Psychopharmacology (Berl). Author manuscript; available in PMC 2011 February 9. Conclusions-The present study demonstrates that the reinforcing effects of ethanol are markedly blunted by activation of the opioidergic N/OFQ receptor system. Moreover, the data provide evidence of the efficacy of N/OFQ to prevent reinstatement of ethanol-seeking behaviour elicited by environmental conditioned stimuli.

show abstract

“…Intracerebroventricular injections of N/OFQ cause various behavioural e ects in rodents, including stimulation of food intake (Pomonis et al, 1996), inhibition or stimulation of spontaneous locomotion (Reinscheid et al, 1995;Florin et al, 1996), antagonism of the reinforcing properties of ethanol or morphine (Ciccocioppo et al, 1999;Murphy et al, 1999) and impairment of spatial learning (Sandin et al, 1997), among other actions. The peptide also a ects nociceptive transmission/perception, inducing either hyperalgesia (Meunier et al, 1995;Reinscheid et al, 1995) or reversal of analgesia mediated or induced by opioids Grisel et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Central injections of nocistatin or its C‐terminal hexapeptide exert anxiogenic‐like effect on behaviour of mice in the plus‐maze test

Gavioli

Rae

Calò

et al. 2002

British J Pharmacology

View full text Add to dashboard Cite

1 Nocistatin (NST) antagonizes several actions of nociceptin/orphanin FQ (N/OFQ), but acts on distinct receptors. As N/OFQ exerts anxiolytic-like actions in various tests, its behavioural actions in the elevated plus-maze (EPM) test were compared with those of bovine NST. 2 Five minutes after i.c.v. treatment, mice were placed on the EPM for 5 min and entries into and time spent on open and closed arms were recorded alongside other parameters. 3 NST (0.1 ± 3 pmol) reduced percentages of entries into (control 39.6+3.1%, peak e ect at 1 pmol NST 8.5+2.9%) and time spent on open arms (control 30.8+2.3%, NST 2.7+1.5%). The C-terminal hexapeptide of NST (NST-C6; 0.01 ± 10 pmol) closely mimicked these actions of NST, with peak e ects at 0.1 pmol. 4 N/OFQ (1 ± 100 pmol) increased percentages of entries into (control 38.5+3.4%; peak e ect at 10 pmol N/OFQ 67.9+4.9%) and time spent on open arms (control 32.0+3.8%; N/OFQ 74.9+5.8%). Closed arm entries, an index of locomotor activity, were unchanged by all peptides. 5 E ects of NST or NST-C6, but not N/OFQ, were still detectable 15 min after injection. Behaviour of animals co-injected with NST (1 pmol) or NST-C6 (0.1 pmol) plus N/OFQ (10 pmol) was indistinguishable from that of controls. 6 These results reveal potent anxiogenic-like actions of NST and NST-C6, and con®rm the anxiolytic-like properties of N/OFQ. As NST and N/OFQ both derive from preproN/OF, anxiety may be modulated in opposing directions depending on how this precursor is processed.

show abstract

Effect of nociceptin on alcohol intake in alcohol-preferring rats

Cited by 125 publications

References 18 publications

The Nociceptin/Orphanin FQ Receptor Agonist Ro 64-6198 Reduces Alcohol Self-Administration and Prevents Relapse-Like Alcohol Drinking

The Nociceptin/Orphanin FQ Receptor Agonist Ro 64-6198 Reduces Alcohol Self-Administration and Prevents Relapse-Like Alcohol Drinking

Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats

Central injections of nocistatin or its C‐terminal hexapeptide exert anxiogenic‐like effect on behaviour of mice in the plus‐maze test

Contact Info

Product

Resources

About