Effect of non-operative management (NOM) of splenic ruptureversussplenectomy on the distribution of peripheral blood lymphocyte populations and cytokine production by T cells

Concise Synthesis of the Antidepressive Drug Candidate GSK1360707 by a Highly Enantioselective Gold‐Catalyzed Enyne Cycloisomerization Reaction

“…An analysis of 275 557 trauma admissions found hollow viscus injuries in association with only 0·3 per cent of blunt injuries, supporting the practice of non‐operative management49. Studies have confirmed long‐term preserved immunocompetence after conservative treatment of high‐grade splenic injury, and preservation should therefore be considered when resources allow adequate follow‐up, albeit with the risk of failure in mind50, 51.…”

The Effects of Splenectomy and Autologous Spleen Transplantation on Complete Blood Count and Cell Morphology in a Porcine Model

“…Autologous spleen transplantation is a method of choice after total splenectomy in order to preserve splenic immune and hematopoietic functions (Marques et al, 2003;Patel et al, 1981). The effectiveness of splenic autotransplant depends on many factors and is still controversial (Theodorou et al, 2007). Studies done on rats, mice, rabbits and men report that autotransplantat's capability of recovering its primary function highly depends on the volume of transplanted spleen tissue (Karagülle et al, 2007;Miko et al, 2003;Resende & Petroianu, 2003;Tang et al, 2003).…”

Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice

“…Since the spleen is an immunoregulatory organ and splenectomy may deteriorate the immunological system and therefore lead to an exaggerated inflammatory status [31], we are unable to rule out the possibility that the absence of spleen also contributed to the development of neuroinflammation. Other surgical procedures are needed to further determine the role of surgical trauma in the neuroinflammation and the following learning and memory changes.…”