Effect of non-surgical periodontal therapy on the salivary levels of omentin-1, a novel adipokine biomarker in periodontitis: A clinico-biochemical study

Abstract

Background. Biomarkers are emerging, advanced diagnostic tools for the assessment of periodontal disease progression. Omentin-1 is an anti-inflammatory adipocytokine, which has been observed and studied in the saliva of periodontitis patients. Non-surgical periodontal therapy (NSPT) is considered a vital part of periodontal disease treatment.Objectives. The study aimed to evaluate the interventional effect of NSPT on the levels of salivary omentin-1 in healthy (H) and chronic periodontitis (CP) patients. Material and methods.A total of 60 participants were selected and equally divided into 2 groups (group A: H participants, group B: CP patients). After obtaining verbal and written consent, whole unstimulated saliva was collected from all participants and analyzed for omentin-1 levels using enzyme-linked immunosorbent assay (ELISA).Results. Mean salivary omentin-1 levels were elevated and found to be significantly higher in group A (95.80 ±26.65) compared to group B (61.97 ±24.53). In group B, there was a substantial rise in omentin-1 levels from baseline to the 6 th week of follow-up (p < 0.001). Thus, NSPT had a positive influence on salivary omentin-1 levels in the treatment group.Conclusions. Salivary omentin-1 levels may serve as diagnostic and prognostic indicators of periodontal disease progression, and may be used to assess therapeutic outcomes in periodontitis patients.

Expression of TNF‐α, omentin‐1, and IL‐6 before and after adjunctive treatment with a bioactive antimicrobial peptide periodontal gel

“…28 Another recent study found that omentin-1 expression was low in patients with periodontitis. 29 Our results demonstrated that treatment with biological AMP periodontal gel led to lower levels of TNF-α and IL-6 compared with those without receiving the treatment, while omentin-1 levels were significantly higher (p < 0.05). This suggested that the gel could effectively reduce inflammatory factor levels among periodontitis patients.…”

“…Previous research has demonstrated that chronic periodontitis can result in the release of inflammatory factors such as TNF‐α, resulting in the damage of alveolar bone 28 . Another recent study found that omentin‐1 expression was low in patients with periodontitis 29 . Our results demonstrated that treatment with biological AMP periodontal gel led to lower levels of TNF‐α and IL‐6 compared with those without receiving the treatment, while omentin‐1 levels were significantly higher ( p < 0.05).…”

Pharmacological therapy in the management of temporomandibular disorders and orofacial pain: a systematic review and meta-analysis

“…NSAIDs can cause ulcers and bleeding in the gastric tract. Studies in the USA found that about 16,000 people die from gastrointestinal side effects [39][40][41][42][43][44][45][46][47].…”

Obesity and Oral Health: The Link Between Adipokines and Periodontitis

“…57,58 An association between reduced salivary omentin-1 levels and increased periodontal parameters was found in patients with chronic periodontitis. [59][60][61] Additionally, higher salivary omentin-1 levels after nonsurgical periodontal therapy were also concomitant with an improvement in the patient's periodontal health status. [59][60][61] Finally, Figure 2 and Table 1 show some of the main pro-and anti-inflammatory actions of the different adipokines contributing to periodontitis.…”

“…[59][60][61] Additionally, higher salivary omentin-1 levels after nonsurgical periodontal therapy were also concomitant with an improvement in the patient's periodontal health status. [59][60][61] Finally, Figure 2 and Table 1 show some of the main pro-and anti-inflammatory actions of the different adipokines contributing to periodontitis.…”