Effect of non-surgical periodontal therapy on renal function in chronic kidney disease patients with periodontitis: a systematic review and meta-analysis of interventional studies

Zhao, Dan; Khawaja, Abrar Tahir; Jin, Lijian; Chan, Kam Wa; Tonetti, Maurizio S.; Tang, Sydney Chi Wai; Pelekos, George

doi:10.1007/s00784-019-03066-w

Cited by 19 publications

(43 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Periodontal disease is a major global oral health problem, but there are currently no therapies available to limit its progression [42][43][44]. The results of the present study demonstrate for the first time that the anti-inflammatory effects of CORM-3 occur via HO-1-dependent pathways in periodontal disease models, and these pathways are mediated through VE-cadherin, ZO-1, and β-catenin expressions.…”

mentioning

confidence: 49%

Carbon Monoxide-Releasing Molecule-3 Suppresses Tumor Necrosis Factor-α- and Interleukin-1β-Induced Expression of Junctional Molecules on Human Gingival Fibroblasts via the Heme Oxygenase-1 Pathway

Liu

Jia

et al. 2020

Mediators of Inflammation

View full text Add to dashboard Cite

Human gingival fibroblast barrier dysfunction caused by inflammation contributes to gingivitis and can lead to inflammatory periodontal disease. The disease features include upregulated epithelial permeability, increased inflammatory mediators, and downregulated junctional complex molecules. Carbon monoxide- (CO-) releasing molecule-3 (CORM-3) is a water-soluble compound that has demonstrated anti-inflammatory effects in in vitro and in vivo studies. In this study, we aimed to investigate the effects of CORM-3 on the expression of tight and adherens junction molecules on human gingival fibroblasts (HGFs) stimulated with tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). HGFs were cultured from the explants of normal human gingival tissues, which were stimulated in the presence or absence of CORM-3. Epithelial barrier function was evaluated by paracellular permeability and junctional complex molecule expression analyses. The protein and mRNA expression levels of adherens junction molecules (VE-cadherin and β-catenin) and tight junction molecules (zona occludens-1, ZO-1) were studied using western blot analysis and reverse transcription-quantitative polymerase chain reaction (RT-PCR). The mRNA and protein expression levels of these cytokines were also analyzed in HGFs transiently transfected with HO-1 small interfering RNA (siRNA) in response to TNF-α and IL-1β stimulation. CORM-3 reduced permeability and enhanced the expression of junctional complex molecules (ZO-1, VE-cadherin, and β-catenin) in TNF-α- and IL-1β-induced HGFs. However, these effects of CORM-3 were attenuated when HO-1 siRNA was transiently transfected in HGFs. These findings indicate that CORM-3 exerts anti-inflammatory effects on TNF-α- and IL-1β-stimulated HGFs via the HO-1 pathway, which suggests the promising potential of CORM-3 in the treatment of inflammatory periodontal disease.

show abstract

mentioning

confidence: 49%

Carbon Monoxide-Releasing Molecule-3 Suppresses Tumor Necrosis Factor-α- and Interleukin-1β-Induced Expression of Junctional Molecules on Human Gingival Fibroblasts via the Heme Oxygenase-1 Pathway

Liu

Jia

et al. 2020

Mediators of Inflammation

View full text Add to dashboard Cite

show abstract

“…Previous studies struggled with a small sample size [22][23][24][25][26][27], their exploratory nature [24,26], and being restricted to patients with ESRD [22,24,25,27]. Two meta-analyses assessed inflammatory markers [38] and kidney function [39], while lacking adequate high-quality evidence from clinical trials. In a multinational cohort study, Palmer and colleagues reported that preventive oral hygiene practices could decrease all-cause mortality but not cardiovascular mortality in hemodialysis patients [25].…”

Section: Discussionmentioning

confidence: 99%

Association between Dental Scaling and Reduced Risk of End-Stage Renal Disease: A Nationwide Matched Cohort Study

Chung

Kuo

Liu

et al. 2021

IJERPH

View full text Add to dashboard Cite

Periodontitis is prevalent in patients with chronic kidney disease (CKD) and is also associated with kidney function decline. It is unclear whether dental scaling treatment prevents the progression of CKD. In a nationwide cohort study, Taiwan’s National Health Insurance Research Database was used to select people with CKD. Propensity score-matching procedures were performed to compare the long-term risk of end-stage renal disease (ESRD) between CKD patients with and without the receipt of dental scaling. A total of 33,637 matched pairs with CKD were included, with 503,373 person-years of follow-up for analyses. Dental scaling was significantly associated with a lower risk of ESRD (adjusted hazard ratio (aHR): 0.83, 95% confidence interval (CI): 0.77–0.90). In addition, there was a dose-dependent relationship between the frequency of dental scaling and a reduced risk of ESRD. Dental scaling was also linked to reduced risks of major adverse cardiovascular events (aHR: 0.91, 95% CI: 0.87–0.95), sepsis (aHR: 0.81, 95% CI: 0.77–0.85), and all-cause mortality (aHR: 0.81, 95% CI: 0.76–0.87). Dental scaling was significantly associated with lower risks of progression to ESRD in patients with CKD. Regular dental scaling may serve as a prophylactic measure for kidney function decline.

show abstract

“…A previous study reported that a low frequency of tooth brushing was associated with risk factors for CKD such as diabetes [26], whereas poor oral health was associated with renal impairment [27]. Another study indicated that clinically successful, non-surgical periodontal treatment both improved glycemic control and reduced the levels of renal impairment biomarkers and albumin in the urine [28,29]. Some studies have also indicated that periodontal treatment results in a signi cant improvement in median kidney function, as well as a reduction in the level of endothelial damage biomarkers, in patients with severe chronic periodontitis [30].…”

Section: Discussionmentioning

confidence: 99%

Frequency of Tooth Brushing as a Predictive Factor for Future Kidney Function Decline

Hirano

Shimbo

Komatsu

et al. 2021

Preprint

View full text Add to dashboard Cite

BackgroundTooth brushing is important for maintaining oral health and preventing periodontal diseases, which commonly arise in patients with chronic kidney disease (CKD). However, the association between tooth brushing frequency and kidney function decline remains unclear. MethodsWe conducted a retrospective longitudinal study at St Luke’s International Hospital, Japan, and participants who underwent health examinations at the Centre for Preventive Medicine from 2005 to 2011 were included. Participants’ tooth brushing frequencies were assessed; multivariate analyses were conducted using a generalized estimating equation to evaluate the association between tooth brushing frequency and a composite renal outcome – composed of a 25% eGFR reduction, an eGFR of <15 mL/min/1.73 m², and a requirement for regular dialysis – after adjusting for potential covariates. We also stratified participants by baseline CKD risk category to perform sub-analyses. ResultsOverall, 76,472 participants were included (mean age of 45.9 years) and 38,233 (50%) were male. During follow-up, 8,219 participants (10.8%) experienced composite renal outcomes. Brushing teeth at least once to twice a day was associated with significantly lower incidences of composite renal outcomes than brushing teeth less frequently (adjusted odds ratio [OR]: 0.26; 95% confidence interval [CI]: 0.24–0.28 for once to twice a day; adjusted OR: 0.65; 95% CI: 0.62–0.69 for after every meal). In our sub-analyses, brushing at least once to twice a day related to a decreased likelihood of composite renal outcomes; however, this effect was only observed within the low and moderate baseline risk groups. ConclusionFrequent tooth brushing benefits oral health and may prevent kidney function decline, which could have implications for other systemic diseases. However, a longitudinal cohort study is required to confirm whether tooth brushing can prevent poor renal outcomes.

show abstract

Effect of non-surgical periodontal therapy on renal function in chronic kidney disease patients with periodontitis: a systematic review and meta-analysis of interventional studies

Cited by 19 publications

References 53 publications

Carbon Monoxide-Releasing Molecule-3 Suppresses Tumor Necrosis Factor-α- and Interleukin-1β-Induced Expression of Junctional Molecules on Human Gingival Fibroblasts via the Heme Oxygenase-1 Pathway

Carbon Monoxide-Releasing Molecule-3 Suppresses Tumor Necrosis Factor-α- and Interleukin-1β-Induced Expression of Junctional Molecules on Human Gingival Fibroblasts via the Heme Oxygenase-1 Pathway

Association between Dental Scaling and Reduced Risk of End-Stage Renal Disease: A Nationwide Matched Cohort Study

Frequency of Tooth Brushing as a Predictive Factor for Future Kidney Function Decline

Contact Info

Product

Resources

About