Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects

Dokkum, W. van; Wezendonk, B.; Srikumar, T.S.; Heuvel, Ellen G. H. M. van den

doi:10.1038/sj.ejcn.1600668

Cited by 157 publications

(101 citation statements)

References 24 publications

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“…Hydrogen production increased nonlinearly with an increasing dose of fructans (up to 30 g: Rumessen & Gudmand-Høyer, 1998). In both our study and the study of Van Dokkum et al (1999), a smaller amount of carbohydrates was available for fermentation due to the spread of the dose over the day. In our study, the volunteers ingested three quarters of the 10 or 15 g/day of NUTRIOSE s FB at breakfast, at t ¼ 120 and at t ¼ 240 min.…”

Section: Breath Hydrogen Excretionmentioning

confidence: 80%

“…This may have resulted in a higher basal breath hydrogen excretion level, which interferes with the effect of NUTRIOSE s FB. Second, like in our study, Van Dokkum et al (1999) spread the dose of 15 g/day of fructo-oligosaccharides over the day and did not find a difference in AUC between the treatment and control (no nondigestible oligosaccharides). Hydrogen production increased nonlinearly with an increasing dose of fructans (up to 30 g: Rumessen & Gudmand-Høyer, 1998).…”

Section: Breath Hydrogen Excretionmentioning

confidence: 99%

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Short-term digestive tolerance of different doses of NUTRIOSE®FB, a food dextrin, in adult men

et al. 2004

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Section: Breath Hydrogen Excretionmentioning

confidence: 80%

Section: Breath Hydrogen Excretionmentioning

confidence: 99%

Short-term digestive tolerance of different doses of NUTRIOSE®FB, a food dextrin, in adult men

et al. 2004

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“…A Korean study (Lee et al, 2004) reported a lowered deoxycholate concentration in faeces of postmenopausal women consuming 8 g/day of inulin, whereas van Dokkum et al (1999) showed similar data in healthy men consuming 15 g/day of inulin or oligofructose.…”

Section: Changes In Faecal Metabolites and Enzyme Activitymentioning

confidence: 95%

“…A number of studies in human volunteers who consumed oligofructose in dosages varying from 13 to 20 g/day revealed an increase in faecal concentrations of lactate, (ten Bruggencate et al, 2006), acetate (van Dokkum et al, 1999), or total SCFA, acetate and propionate (Grasten et al, 2003). In one study (Causey et al, 2000), only a non-significant trend for increased acetate and total SCFA was found in faecal samples of volunteers consuming 20 g/day of inulin.…”

Section: Changes In Faecal Metabolites and Enzyme Activitymentioning

confidence: 97%

The bifidogenic effect of inulin and oligofructose and its consequences for gut health

Meyer¹,

2009

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The bifidogenic effect of inulin and oligofructose is now well established in various studies, not only in adult participants but also in other age groups. This bifidogenic shift in the composition of the colonic microbiota is likely the basis for the impact of these prebiotic compounds on various parameters of colonic function. Mainly from animal and in vitro studies and also from some human trials, there are indications, for instance, that inulin-type fructans may reduce the production of potentially toxic metabolites and may induce important immune-mediated effects. This review discusses how these changes in the composition and activity of the colonic microbiota may affect gut health in healthy people, including in those who may experience some form of gastrointestinal discomfort.

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“…GOS have been found to relieve constipation in Japanese studies, too (Deguchi et al, 1997;Shitara, 1988). GOS are in general well-tolerated (van Dokkum et al, 1999;Boehm et al, 2002;Moro et al, 2002). However, because of fermentation, symptoms such as abdominal bloating and flatulence may occur in sensitive subjects when large quantities of GOS are ingested (Ito et al, 1990;.…”

Section: Introductionmentioning

confidence: 99%

Yoghurt containing galacto-oligosaccharides, prunes and linseed reduces the severity of mild constipation in elderly subjects

et al. 2007

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Objective: Constipation is a common problem in the elderly. Dietary fibre is recommended for its treatment. The aim was to examine whether yoghurt containing galacto-oligosaccharides (GOS), prunes and linseed relieve constipation in elderly subjects. Design: A randomized, double-blinded, cross-over study. Setting: Free-living subjects. Subjects: A group of 43 elderly subjects with self-reported constipation (mean age 76 years, range 61-92 years, 32 females, 11 males). Interventions: The study consisted of a 2-week baseline period and 2, 3-week dietary interventions, with a 2-week wash-out period between the interventions. During the interventions, the subjects ingested, in random order, 260 g/day of either control yoghurt or test yoghurt containing GOS (12 g/day), prunes (12 g/day) and linseed (6 g/day). The use of laxatives was controlled and only allowed after 2 days without defecation. Results: Defecation frequency was 5.7 times/week during the baseline period. During the test yoghurt period, defecation frequency was higher (8.0 vs 7.1 times/week, P ¼ 0.011), defecation was easier (on the scale 0-3, 1.3 vs 1.5, P ¼ 0.010), and there was a tendency towards softer stools (on the scale 0-3, 2.1 vs 2.2, P ¼ 0.059) compared with the control yoghurt period. The subjects felt that the test yoghurt relieved constipation more effectively than the control yoghurt (P ¼ 0.005). The sum of gastrointestinal symptoms did not differ between the interventions. The use of laxatives remained constant throughout the study. Conclusions: Daily intake of yoghurt containing GOS, prunes and linseed reduced the severity of constipation in elderly subjects with mild constipation.

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Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects

Cited by 157 publications

References 24 publications

Short-term digestive tolerance of different doses of NUTRIOSE®FB, a food dextrin, in adult men

Short-term digestive tolerance of different doses of NUTRIOSE®FB, a food dextrin, in adult men

The bifidogenic effect of inulin and oligofructose and its consequences for gut health

Yoghurt containing galacto-oligosaccharides, prunes and linseed reduces the severity of mild constipation in elderly subjects

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