Effect of noradrenaline on triglyceride and glycogen concentrations in liver and muscle from man

Fröberg, Sven O.; Hultman, Erik; Nilsson, Lennart

doi:10.1016/0026-0495(75)90012-8

Cited by 33 publications

(25 citation statements)

References 24 publications

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“…The sensitivity of lipolytic activity toward these two catecholamines might be higher in females than in males in skeletal muscle tissue as well. It has previously been shown that the initial content of MCTG influences the use of MCTG during both exercise (8) and infusion of norepinephrine at rest (10). In the present study, the gender difference in MCTG utilization during exercise is at least partly explained by the gender difference in resting content of MCTG, because we observed a fair (r ϭ 0.61) and significant (P Ͻ 0.001) correlation between these two parameters.…”

Section: Discussionsupporting

confidence: 65%

Myocellular triacylglycerol breakdown in females but not in males during exercise

Steffensen

Roepstorff

Madsen

et al. 2002

American Journal of Physiology-Endocrinology and Metabolism

190

186

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.-The resting content and use of myocellular triacylglycerol (MCTG) during 90 min of submaximal exercise [60% of peak oxygen uptake (V O2 peak)] were studied in 21 eumenorrheic female and 21 male subjects at different training levels [untrained (UT), moderately trained (MT), and endurance trained (END)]. Males and females were matched according to their V O2 peak expressed relative to lean body mass, physical activity level, and training history. All subjects ingested the same controlled diet for 8 days, and all females were tested in the midfollicular phase of the menstrual cycle. Resting MCTG, measured with the muscle biopsy technique, averaged 48.4 Ϯ 4.2, 48.5 Ϯ 8.4, and 52.2 Ϯ 5.8 mmol/kg dry wt in UT, MT, and END females, respectively, and 34.1 Ϯ 4.9, 31.6 Ϯ 3.3, and 38.4 Ϯ 3.0 mmol/kg dry wt in UT, MT, and END males, respectively (P Ͻ 0.001, females vs. males in all groups). Exercise decreased MCTG content in the female subjects by an average of 25%, regardless of training status, whereas in the male groups MCTG content was unaffected by exercise. The arterial plasma insulin concentration was higher (P Ͻ 0.05) and the arterial plasma epinephrine concentration was lower (P Ͻ 0.05) in the females than in the males at rest and during exercise. MCTG use was correlated to the resting concentration of MCTG (P Ͻ 0.001). We conclude that resting content and use of MCTG during exercise are related to gender and furthermore are independent of training status. muscle substrate; training; triglycerides IT HAS PREVIOUSLY BEEN SHOWN (25) that myocellular triacylglycerol (MCTG) is utilized during the postexercise period. MCTG stores also represent a potentially large energy source during exercise. However, the extent to which MCTG is used during exercise and the possible existence of differences in its use between trained and untrained (UT) subjects are still under debate. In studies (27, 37) using stable isotope techniques combined with indirect calorimetry, it was estimated that MCTG accounted for 20-25% of the oxidative metabolism during submaximal exercise. However, when direct measurements of MCTG concentration in muscle biopsies have been used, some studies (4, 19, 34) have found a decrease in MCTG concentration during submaximal exercise, whereas others (1, 21, 22, 25, 44) have observed no change. In all of the above-mentioned studies, only male subjects have participated. Thus it is unknown whether gender differences exist in the utilization of MCTG during exercise. Some studies (18,45,46) have shown that females utilize lipids to a greater extent than males during submaximal exercise, but to our knowledge it has not been investigated whether this increased lipid utilization in females is primarily from MCTG or other lipid sources. Other studies (3, 6, 32) have not been able to find gender differences in lipid utilization during exercise. This could be due to differences in training status and exercise mode in the experimental designs. The aim of the present study was therefore to evaluate the contribution of MCT...

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Section: Discussionsupporting

confidence: 65%

Myocellular triacylglycerol breakdown in females but not in males during exercise

Steffensen

Roepstorff

Madsen

et al. 2002

American Journal of Physiology-Endocrinology and Metabolism

190

186

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“…Thus, in agreement with previous findings [6,20], immuno-inhibition of MOME activity was not complete (Figure 4), and immunoprecipitation reduced MOME activity significantly less than muscle-HSL protein concentration (Table 1). In addition to neutral lipase skeletal muscle also contains an acid lysosomal lipase as well as the alkaline lipoprotein lipase, but these enzymes cannot be involved in physiological regulation of the intramuscular triglyceride stores [3]. This fact, the finding that adrenaline stimulates muscle HSL [6], and the present findings strongly indicate that HSL is the enzyme responsible for hydrolysis of triglyceride in skeletal muscle.…”

Section: Discussionmentioning

confidence: 49%

“…The energy content of this triglyceride depot is higher than the energy content of the muscle glycogen pool [2], and the triglycerides can be mobilized by catecholamines [3,4]. For more than a decade it was believed that the breakdown of triglyceride in muscle was regulated by lipoprotein lipase [1].…”

Section: Introductionmentioning

confidence: 99%

Stimulation of hormone-sensitive lipase activity by contractions in rat skeletal muscle

Langfort

Ploug²,

Ihlemann³

et al. 2000

Biochemical Journal

114

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“…[4] During periods of increased muscle contractile activity, muscle lipase is activated by hormonal actions which leads to the release of FA from the intramuscular TG. Whereas norepinephrine infusion has been observed to cause a significant reduction in muscle TG, [26] insulin counteracts this effect. [27] Apart from hormonal stimuli, there is also local muscular control of lipase activity, shown by the observation that electrical stimulation of muscle enhances TG breakdown [28][29][30][31] Compared with fast twitch muscle fibres, slow twitch fibres have a high lipase, [10,32] as well as TG, content.…”

Section: Factors Limiting Fatty Acid Uptake By Muscle Cellsmentioning

confidence: 99%

Strategies to Enhance Fat Utilisation During Exercise

Hawley

Brouns²,

Jeukendrup³

1998

Sports Medicine

101

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Effect of noradrenaline on triglyceride and glycogen concentrations in liver and muscle from man

Cited by 33 publications

References 24 publications

Myocellular triacylglycerol breakdown in females but not in males during exercise

Myocellular triacylglycerol breakdown in females but not in males during exercise

Stimulation of hormone-sensitive lipase activity by contractions in rat skeletal muscle

Strategies to Enhance Fat Utilisation During Exercise

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