Effect of obesity on diurnal patterns of testosterone and dehydroepiandrosterone in male subjects

Guimard, Alexandre; Vibarel-Rebot, N.; Prieur, Fabrice; Baillot, Aurélie; Mongeois, E.; Barrande, M.-G.; Lasne, Françoise; Collomp, K.

doi:10.1016/j.scispo.2013.06.001

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Other studies reported decreased free testosterone levels in males with visceral obesity while increased levels were observed in obese women (Diaz-Arjonilla et al, 2009;Kaplan et al, 2006;Tchernof et al, 2004). Few studies focused the attention on T circadian pattern and it was just reported that obese subjects had lower amplitude of T rhythm, with lower levels in the morning, compared to healthy controls (Guimard et al, 2013).…”

Section: Obesitymentioning

confidence: 99%

Biological rhythms, chronodisruption and chrono-enhancement: The role of physical activity as synchronizer in correcting steroids circadian rhythm in metabolic dysfunctions and cancer

Vitale

Lombardi

Weydahl

et al. 2018

Chronobiology International

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Rhythms can be observed at all levels of the biologic integration in humans. The observation that a biological or physiological variable shows a circadian rhythm can be explained by several multifactorial systems including external (exogenous), internal (endogenous) and psychobiological (lifestyle) mechanisms. Our body clock can be synchronized with the environment by external factors, called "synchronizers", i.e. the light-dark cycle, but it is also negatively influenced by some pathological conditions or factors, called "chronodisruptors," i.e. aging or low physical activity (PA). The desynchronization of a 24-h rhythm in a chronic manner has been recently defined "chronodisruption" or "circadian disruption." A very large number of hormonal variables, such as adrenal and gonadal stress steroids, are governed by circadian rhythmicity. Such hormones, in normal conditions, show a peak in the first part of the day, while their typical diurnal fluctuations are totally out of sync in subjects affected by cancer or metabolic diseases, such as obesity, diabetes and metabolic syndrome. In general, a flatter slope with altered peaks in cortisol and testosterone circadian rhythms has been observed in pathological individuals. PA, specifically chronic exercise, seems to play a key role as synchronizer for the whole circadian system in such pathologies even if specific data on steroids circadian pattern are still sparse and contradictory. Recently, it has been proposed that low-intensity chronic PA could be an effective intervention to decrease morning cortisol levels in pathological subjects. The standardization of all confounding factors is needed to reach more clear evidence-based results.

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Section: Obesitymentioning

confidence: 99%

Biological rhythms, chronodisruption and chrono-enhancement: The role of physical activity as synchronizer in correcting steroids circadian rhythm in metabolic dysfunctions and cancer

Vitale

Lombardi

Weydahl

et al. 2018

Chronobiology International

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“…The slight but statistically insignificant change of testosterone in the control treatment is concordant with normal diurnal rhythms of testosterone in adolescent males who typically display early morning peak testosterone and late evening nadir . Furthermore, obesity has been shown to alter diurnal patterns of testosterone in males and lower morning testosterone values . Though both groups had elevated LH levels during the control treatment, overweight subjects had significantly lower testosterone at baseline.…”

Section: Discussionmentioning

confidence: 99%

“…30 Furthermore, obesity has been shown to alter diurnal patterns of testosterone in males and lower morning testosterone values. 31 Though both groups had elevated LH levels during the control treatment, overweight subjects had significantly lower testosterone at baseline.…”

Section: Discussionmentioning

confidence: 99%

Acute decrease in plasma testosterone and appetite after either glucose or protein beverages in adolescent males

Schwartz

Hunschede

Lacombe

et al. 2019

Clinical Endocrinology

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Objective Chronic testosterone blood concentrations associate with food intake (FI), but acute effects of testosterone on appetite and effect of protein and glucose consumption on testosterone response have had little examination. Methods In a randomized, crossover study, twenty‐three adolescent (12‐18 years old) males were given beverages containing either: (a) whey protein (1 g/kg body weight), (b) glucose (1 g/kg body weight) or (c) a calorie‐free control (C). Plasma testosterone, luteinizing hormone (LH), GLP‐1 (active), ghrelin (acylated), glucose, insulin and subjective appetite were measured prior (0) and at 20, 35 and 65 minutes after the consumption of the beverage. FI at an ad libitum pizza meal was assessed at 85 minutes. Results Testosterone decreased acutely to 20 minutes after both protein and glucose with the decrease continuing after protein but not glucose to 65 minutes (P = 0.0382). LH was also decreased by both protein and glucose, but glucose had no effect at 20 minutes in contrast to protein (P < 0.001). Plasma testosterone concentration correlated positively with LH (r = 0.58762, P < 0.0001) and negatively with GLP‐1 (r = −0.50656, P = 0.0003). No associations with appetite, ghrelin or glycaemic markers were found. Food intake was not affected by treatments. Conclusion Protein or glucose ingestion results in acute decreases in both plasma testosterone and LH in adolescent males. The physiological significance of this response remains to be determined as no support for testosterone's role in acute regulation of food intake was found.

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Altered diurnal pattern of steroid hormones in relation to various behaviors, external factors and pathologies: A review

Collomp

Baillot

Forget

et al. 2016

Physiology & Behavior

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Effect of obesity on diurnal patterns of testosterone and dehydroepiandrosterone in male subjects

Cited by 3 publications

References 12 publications

Biological rhythms, chronodisruption and chrono-enhancement: The role of physical activity as synchronizer in correcting steroids circadian rhythm in metabolic dysfunctions and cancer

Biological rhythms, chronodisruption and chrono-enhancement: The role of physical activity as synchronizer in correcting steroids circadian rhythm in metabolic dysfunctions and cancer

Acute decrease in plasma testosterone and appetite after either glucose or protein beverages in adolescent males

Altered diurnal pattern of steroid hormones in relation to various behaviors, external factors and pathologies: A review

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