Effect of obesity on pulmonary function in children

Inselman, Laura S.; Milanese, A; Deurloo, Antoinette

doi:10.1002/ppul.1950160209

Cited by 94 publications

(77 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We confirmed the association between being overweight and modifications of lung volumes (RV/total lung capacity (TLC) and FRC/TLC) using two approaches: namely the BMI z-scores and IOTF grades. We did not observe a reduction in TLC (restrictive defect), which is a rare pattern, even in adults [43,44]. This could have been related to the low prevalence of severe obesity in our series.…”

Section: Discussionmentioning

confidence: 62%

Overweight is not a comorbidity factor during childhood asthma: the GrowthOb study

Mahut

Beydon²,

Delclaux³

2011

Eur Respir J

View full text Add to dashboard Cite

While being overweight is a risk factor for subsequent asthma in children, the importance of body mass index (BMI) as a comorbidity factor remains debated. The aim of this study was to assess the relationships between being overweight and the characteristics of childhood asthma.The BMI, BMI z-scores and International Obesity Task Force (IOTF) grades were evaluated in asthmatic children according to atopic status, symptoms during the past 3 months, exercise breathlessness, treatment and lung function in 6-15-yr-old children with confirmed asthma.491 asthmatic children (mean¡SD age 10.8¡2.6 yrs; 179 females) were prospectively enrolled. There were 78 (15.5%) overweight (IOTF grade 1) and eight (1.6%) obese (grade 2) children. The children's BMI z-scores did not differ according to atopy, exacerbation, symptom-free days or treatment. The BMI z-score correlated positively with forced vital capacity and forced expiratory volume in 1 s in females, which could be related to earlier puberty in overweight females (growth spurt with increased volumes). Compared with normal weight children, overweight and obese children had reduced lung volume ratios (functional residual capacity/total lung capacity (TLC) and residual volume/TLC), no evidence of airflow limitation and similar symptoms.In conclusion, the observed functional relationships with BMI are not specific to asthma and being overweight is not associated with significant clinical impacts on asthma during childhood.KEYWORDS: Body mass index, lung function, lung volumes, obesity, z-score I n the paediatric population, an increase in body mass index (BMI) is associated with the increased incidence [1] and prevalence [2] of asthma. The role of being overweight as a comorbidity factor is said to be ''possibly important, yet poorly studied '' [3]. Conflicting results on the relationship between BMI and asthma phenotype have been published. Being overweight has been associated with the severity of asthma exacerbations [4,5], as well as with poor asthma control [6]. However, in an important retrospective study, no effect of BMI on the time required to achieve control of asthma or on the ability to maintain good control of asthma was shown [7]. BMI per se has also been inconsistently correlated with clinical symptoms, such as coughing and wheezing on exertion [8], and with an increase in the number of symptom days and in the number of exacerbations in females only [9]. Such discrepancies between results might partially be due to the various cut-off points of BMI that are used across studies to define overweight and obesity (frequently the 85th or 95th percentiles). Normal values of BMI are age-and sex-specific throughout childhood; therefore, the transformation of children's BMI values into sex-and age-specific zscores is mandatory in order to ascertain the relationships between stoutness and clinical events and lung function. To further study the effect of overweight/obesity during childhood, the grades of COLE and co-workers [10,11] of the International Obesity Ta...

show abstract

Section: Discussionmentioning

confidence: 62%

Overweight is not a comorbidity factor during childhood asthma: the GrowthOb study

Mahut

Beydon²,

Delclaux³

2011

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…31,32 Obesity is associated with lung changes (e.g., decreased lung volumes, decreased CO diffusion, and bronchodilation after Ventolin challenge 33 ). These lung changes, which may manifest as the symptoms diagnosed as asthma, probably are the result of mechanical changes from obesity.…”

Section: Discussionmentioning

confidence: 99%

Asthma and body weight change: a 20-year prospective community study of young adults

Hasler

Gergen

Ajdacic³

et al. 2006

Int J Obes

View full text Add to dashboard Cite

Objective: There is increasing evidence for an association between asthma and body weight change. The objectives of these analyses were to examine the temporal relationships of this association and to explore the role of childhood depression as an explanatory factor. Methods: Data were derived from six subsequent semistructured interviews on health habits and health conditions from a single-age community study of 591 young adults followed up between ages 20 and 40 years. Results: Cross-sectionally (over the whole study period), asthma was significantly associated with obesity (odds ratio ¼ 3.9 [95% confidence interval 1.2, 12.2]). Multivariate longitudinal analyses revealed that asthma was associated with increased later weight gain and later obesity among women after controlling for potentially confounding variables, whereas weight gain and obesity were not associated with later asthma. A secondary analysis showed that depressive symptoms during childhood were associated with adult obesity and asthma, partially explaining the asthma-obesity comorbidity. Conclusion: This study encourages further research on mechanisms underlying the asthma-obesity comorbidity, particularly on shared psychosocial factors operating during critical periods in childhood and adolescence that may influence the development and persistence of both obesity and asthma during adulthood.

show abstract

“…Os problemas com crianças obesas incluem distúrbios metabólicos e físicos, além de estresse psicossocial. Alterações da função respiratória foram relatadas em muitos estudos [2][3][4] .…”

Section: Introductionunclassified

Impact of obesity on ventilatory function

et al. 2007

View full text Add to dashboard Cite

ResumoObjetivo: Embora a obesidade tenha sido associada ao comprometimento grave da ventilação, a maior parte da população estudada constitui-se de adultos com obesidade mórbida. Nosso objetivo foi investigar os efeitos da obesidade leve na função ventilatória de pacientes pediátricos.Métodos: Estudo transversal controlado que analisou 80 pacientes (M/F: 35/45) avaliados em nosso ambulatório, com queixa de sobrepeso, sem histórico de asma ou de outras atopias, comparando-os a um grupo controle com 50 crianças de peso normal controladas para a idade e para o sexo. A média de idade dos pacientes foi de 9,7±2,5 anos (7 a 15 anos). AbstractObjective: Although obesity was found to be associated with severe impairment of ventilation, most of the study population has been morbidly obese adults. We aimed to explore the effects of mild obesity on ventilatory function in the pediatric age group. Methods:In a cross-sectional controlled study, 80 patients (M/F: 35/45), who were evaluated in our outpatient clinic with the complaint of excess body weight, with no history of asthma or other atopic diseases were studied and compared to a control group of 50 normal weight children controlled for age and sex. The mean age of patients was 9.7±2.5 years (7 to 15 years). Anthropometric measurements and spirometry were performed in all subjects. Forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) were used as measures of ventilatory function.Results: There were no significant differences in FEV1%, FVC% and FEV1%/FVC% by study group (p > 0.05). Only three patients had obstructive abnormalities documented on their pulmonary function tests (two had moderately severe and one had mild obstructive abnormalities).No correlation was observed between pulmonary function parameters and anthropometric measurements.Conclusion: These data demonstrate that pulmonary function test parameters of the mildly obese children were similar to those of the normal weight children. Anthropometric measurements had no significant effect on spirometric measurements in children as they did on adults.J Pediatr (Rio J). 2007;83(2):171-176: Obesity, ventilatory function, spirometry.

show abstract

Effect of obesity on pulmonary function in children

Cited by 94 publications

References 19 publications

Overweight is not a comorbidity factor during childhood asthma: the GrowthOb study

Overweight is not a comorbidity factor during childhood asthma: the GrowthOb study

Asthma and body weight change: a 20-year prospective community study of young adults

Impact of obesity on ventilatory function

Contact Info

Product

Resources

About