Effect of obstructive jaundice on hepatic hemodynamics: use of Sonazoid-enhanced ultrasonography in a prospective study of the blood flow balance between the hepatic portal vein and hepatic artery

Wakui, Noritaka; Takeda, Yoshihiko; Nishinakagawa, Shuta; Ueki, Nobuo; Otsuka, Takafumi; Oba, Nobuyuki; Hashimoto, Hiroshi; Kamiyama, Naohisa; Sumino, Yasukiyo; Kojima, Toshihisa

doi:10.1007/s10396-015-0629-1

Cited by 3 publications

(1 citation statement)

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“…Based on renal hypoperfusion, disturbances and changes in renal hemodynamics are the basic mechanisms underlying OJKI. Hypotension resulting from hemodynamic disturbance further aggravates the ischemic state of the kidney[ 39 ] which is highly sensitive to ischemia and prone to renal insufficiency[ 40 ]. The renin-angiotensin-aldosterone system (RAAS) is a key player in the progression of renal diseases.…”

Section: Pathophysiological Consequencesmentioning

confidence: 99%

Pathophysiological consequences and treatment strategy of obstructive jaundice

Liu¹,

Sun²,

Xu³

et al. 2023

World J Gastrointest Surg

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Obstructive jaundice (OJ) is a common problem in daily clinical practice. However, completely understanding the pathophysiological changes in OJ remains a challenge for planning current and future management. The effects of OJ are widespread, affecting the biliary tree, hepatic cells, liver function, and causing systemic complications. The lack of bile in the intestine, destruction of the intestinal mucosal barrier, and increased absorption of endotoxins can lead to endotoxemia, production of proinflammatory cytokines, and induce systemic inflammatory response syndrome, ultimately leading to multiple organ dysfunction syndrome. Proper management of OJ includes adequate water supply and electrolyte replacement, nutritional support, preventive antibiotics, pain relief, and itching relief. The surgical treatment of OJ depends on the cause, location, and severity of the obstruction. Biliary drainage, surgery, and endoscopic intervention are potential treatment options depending on the patient's condition. In addition to modern medical treatments, Traditional Chinese medicine may offer therapeutic benefits for OJ. A comprehensive search was conducted on PubMed for relevant articles published up to August 1970. This review discusses in detail the pathophysiological changes associated with OJ and presents effective strategies for managing the condition.

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Section: Pathophysiological Consequencesmentioning

confidence: 99%