Effect of occlusal splint on oxidative stress markers and psychological aspects of chronic temporomandibular pain: a randomized controlled trial

Alajbeg, Iva; Vrbanović, Ema; Lapić, Ivana; Vuletić, Lea

doi:10.1038/s41598-020-67383-x

Cited by 21 publications

(12 citation statements)

References 38 publications

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“…There was a report of no improvement with the use of occlusal splints. without cognitive therapy [59], and reports of improvement with hard and soft splints [64,65]. Piancino et al [60] and Miralles et al [51] showed improvement in the pattern of movement of the SS, with positive influence on the cervical spine, respectively, when using JFO, corroborating the findings of the present investigation.…”

Section: Discussionsupporting

confidence: 90%

Treatment of temporomandibular dysfunction with jaw functional orthopedics: a retrospective study

Júnior¹,

Ferreira²,

Huebner³

2021

Jaw funct. orthop., craniofac. growth

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What are my chances of getting better?" And "How long will it take for the discomfort to improve?" are the two basic questions asked by individuals after they know about the influence of the stomatognathic system (SS) on their discomfort. Despite the biological unpredictability and variation, these individuals need some information. When searching in MEDLINE, some parameters may be found, but there are none about Jaw Functional Orthopedics (JFO). This study sample was composed of 146 patients with TMD and/or headache/neck pains, who were treated with JFO and divided into three groups. Group 1 exclusively with TMD; Group 2 with head and/or neck pain without symptoms of TMD (pain on palpation or movement); and Group 3 with TMD and head/neck pain. The symptoms monitored were arthralgia, and myalgia of the temporal, masseter or suprahyoid muscles, neck pain on movement or palpation, headache and cervicalgia reported. Odontogenic pain and headache originating from other sources (sinusitis, flu, pre-menstrual period, photophobia, hangover, etc.) were excluded from the study. The sample was aligned with the literature relative to prevalence of age and sex. Results showed that JFO treatment was effective in patients of the three groups. There was no statistical difference in mean time for remission among the groups. The results and conclusions should be analyzed with caution since there was no control group, and long term follow up is needed to check the behavior of the symptoms. However, the data from this study suggested that JFO was an efficient tool for treatment of patients with occlusal and biomechanical alterations of the SS, with chronic TMD, head and/or neck pain in a short period of time.

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Section: Discussionsupporting

confidence: 90%

Treatment of temporomandibular dysfunction with jaw functional orthopedics: a retrospective study

Júnior¹,

Ferreira²,

Huebner³

2021

Jaw funct. orthop., craniofac. growth

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“…They were given only basic information about the nature of the diagnosis and the therapeutic device assigned to them. The design of the device was explained in our previous research 24 . All contacts that interfered with simultaneous contact at maximum intercuspation were removed, allowing the vertical dimension of the occlusion to increase by <0.5 mm which we considered as negligible effect on occlusion and condyle position.…”

Section: Methodsmentioning

confidence: 99%

“…The design of the device was explained in our previous research. 24 All contacts that interfered with simultaneous contact at maximum intercuspation were removed, allowing the vertical dimension of the occlusion to increase by <0.5 mm which we considered as negligible effect on occlusion and condyle position. Participants were instructed to wear the device only during sleep.…”

Section: Control Therapymentioning

confidence: 99%

Treatment responses in chronic temporomandibular patients depending on the treatment modalities and frequency of parafunctional behaviour

Gikić

Vrbanović

Zlendić

et al. 2021

J of Oral Rehabilitation

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Objectives: (i) To evaluate the effect of three different interventions on treatment outcomes and (ii) to determine how the frequency of oral parafunction influences the effectiveness of the different therapeutic modalities.Methods: Forty-five participants were randomly assigned into three treatment groups [physical therapy (PT), stabilisation splint (SS) and control therapy (CT)]. According to Oral Behavior Checklist score, participants were divided into "high-frequency parafunction" (HFP) and low-frequency parafunction" (LFP) group. Primary (spontaneous pain and characteristic pain intensity) and secondary outcomes (range of mouth opening, anxiety symptoms, quality of life, perceived stress and global functional limitation) were evaluated during six-month treatment period.Results: Participants in PT group showed a significant reduction in characteristic pain intensity (p = .047, η 2 = 0.243) when compared to SS and CT group, but significant improvement in spontaneous pain was found in all treatment groups. Patients treated with PT and SS exhibited significantly stronger improvement in pain-free mouth opening than patients in CT group (3rd month: p=.037, η2=0.258; 6th month: p = .005, η 2 = 0.383). Within-group analyses showed significant decrease of perceived stress, anxiety symptoms and global functional limitation only in PT group over a sixmonth treatment period. Participants with HFP presented significantly greater levels of anxiety (3rd month: p = .009, η 2 = 0.275; 6th month: p = .041, η 2 = 0.176) than participants with LFP. Within-group analyses, however, showed significant improvement of anxiety, but also the decrease of perceived stress and improvement of global limitation for the HFP group but not for the LFP group. Conclusion:Although no treatment can be marked as superior in terms of spontaneous pain relief, PT was more effective when observing relief of characteristic pain intensity. In HFP group the reduction of anxiety, stress and functional limitation was present regardless of the applied therapy. Trial registration: ClinicalTrials.gov NCT04694274. Registered on 01/04/2021.

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“…PHQ-9 is a nine-item questionnaire designed to screen for depression with responses based on a four-point Likert scale (from not at all to almost every day) with possible scores from 0 to 27 (Alajbeg et al, 2020). GAD-7 is a seven-item questionnaire used to assess the severity of anxiety symptoms with responses based on a Likert scale (from not at all to almost every day) with possible scores from 0 to 21 (Gikić et al, 2021).…”

Section: Diagnosis Of Temporomandibular Disordersmentioning

confidence: 99%

Association of oral behaviours and psychological factors with selected genotypes in pain‐related TMD

et al. 2023

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ObjectivesTo investigate frequency of single nucleotide polymorphisms (SNPs) in pain‐related temporomandibular disorders (TMDp) and to determine whether specific SNPs, psychological, psychosomatic and behavioural characteristics are predictive for pain existence and intensity (low pain intensity (LPI)/high pain intensity (HPI)).MethodsGenomic DNA was extracted from buccal mucosa swabs (85 TMDp;85 controls) for evaluating frequency of selected SNPs: catechol‐O‐methyltransferase (rs4680, rs4818), opiorphin (rs1387964), alpha subunit of voltage‐gated sodium channel Nav1.1 (rs6432860) and voltage‐gated sodium channel Nav1.9 (rs33985936). Participants completed questionnaires on somatosensory amplification, anxiety and depression symptoms and oral behaviours (OB).ResultsSleep‐related OB frequency was higher in TMDp patients compared to controls (p = 0.008). Compared to LPI, HPI patients had higher depression (p = 0.020) and anxiety scores (p = 0.017). TMDp group showed higher frequency of CC genotype (rs1387964) than controls (12.9% vs. 3.5%, p = 0.025). Following adjustments for age, sex and sleep‐related OB, the significance of the recessive model (CC vs. TC + TT) between TMDp patients and controls was retained (OR = 5.783; 95%CI: 1.454–23.004). Frequency of GG genotype (rs4680 and rs4818) was higher in HPI compared to LPI patients (40% vs. 11.4%, p = 0.006; 24% vs. 3%; p = 0.012, respectively). The difference remained significant after adjusting for age, sex, depression, anxiety and sleep‐related OB (rs4680: OR = 3.621; 95%CI: 1.580–8.297; rs4818: OR = 4.919, 95%CI: 1.641–14.746).ConclusionThis study has demonstrated that rs1387964 CC genotype was associated with TMDp while rs4680 GG and rs4818 GG genotypes contributed to HPI.

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Effect of occlusal splint on oxidative stress markers and psychological aspects of chronic temporomandibular pain: a randomized controlled trial

Cited by 21 publications

References 38 publications

Treatment of temporomandibular dysfunction with jaw functional orthopedics: a retrospective study

Treatment of temporomandibular dysfunction with jaw functional orthopedics: a retrospective study

Treatment responses in chronic temporomandibular patients depending on the treatment modalities and frequency of parafunctional behaviour

Association of oral behaviours and psychological factors with selected genotypes in pain‐related TMD

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