Effect of Oilseed Diets on Plasma Lipid Profile in Albino Rats

Ajayi, Olubunmi Bolanle; Ajayi, D. D.

doi:10.3923/pjn.2009.116.118

Cited by 23 publications

(7 citation statements)

References 12 publications

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“…The highest level of hepatic cholesterol was recorded in rats that were fed on HFD containing PKO followed by those fed on PO, corn oil and ghee in a descending order. Present results confirmed previous results by Bolanle and Dais [10] who concluded that dietary intake of PKO could pose a risk for coronary artery disease on a long term basis and also confirmed the Joint FAO/WHO Expert Consultation, [32] which stated that lauric (C12:0), myristic (C14:0) and palmitic acids (C16:0) consumption caused an increase in LDL-Cholesterol whereas stearic (C18:0) had no effect on LDL-Cholesterol and replacing saturated fatty acids (C12:0 -C16:0) with polyunsaturated fatty acids decreased both LDL-Cholesterol concentration and the total cholesterol/HDLcholesterol ratio. The significantly lower total antioxidant capacity level for rats fed on HFD, compared to rats fed on basal diet, was recorded in rats that were fed on HFD containing PKO which confirmed previous results in this study of the possible health risk of using this oil "PKO" as the major source of fat in the diet.…”

Section: Discussionsupporting

confidence: 83%

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Palm kernel oil increases the risk of coronary heart disease in rats compared with ghee

Khairy¹,

Morsi²,

Galal³

et al. 2014

IOSRJPBS

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Section: Discussionsupporting

confidence: 83%

“…Feeding rats on high PO diet caused hepatic steatosis [9]. Dietary intake of PKO could pose a risk for coronary artery disease on a long term basis [10]. It was suggested that non-extreme short-term changes in PO and dietary cholesterol consumption lead to significant elevations in plasma TC and LDL-C in humans [11].…”

Section: Introductionmentioning

confidence: 99%

Palm kernel oil increases the risk of coronary heart disease in rats compared with ghee

Khairy¹,

Morsi²,

Galal³

et al. 2014

IOSRJPBS

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“…Studies have shown that diets rich in saturated fatty acids (SFA) increased the LDL-C [28]. The higher the level of LDL cholesterol, the greater the risk of atherosclerotic heart disease conversely and the higher the level of HDL cholesterol the lower the risk of coronary heart disease [29,30].…”

Section: Discussionmentioning

confidence: 99%

Effect of Different Vegetable Oils (Red Palm Olein, Palm Olein, Corn Oil and Coconut Oil) on Lipid Profile in Rat

Dauqan¹,

Sani²,

Abdullah³

et al. 2011

FNS

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“…Lipid profile disorders are among the most common metabolic diseases occurring in humans and are a risk index of coronary heart disease (Edem, 2002;O. B. Ajayi & D. D. Ajayi, 2009).…”

Section: Introductionmentioning

confidence: 99%

Antihyperlipidaemic and Antioxidant Potential of Fermented Citrullus vulgaris Seeds (Thunb.) on Tyloxapol-induced Hyperlipidaemic Rats: A Comparison With Fluvastatin

Ayo-Lawal¹,

Osoniyi²,

Famurewa³

2015

JFR

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Globally fermented foods form an integral part of the staple diet of people. Fermented Citrullus vulgaris (FCV) (ogiri) seeds is a nutritious natural fermented condiment that features frequently in West African diets as a spice. This study investigated the antihyperlipidaemic potential of this condiment in tyloxapol-induced hyperlipidaemic rats with reference to that of fluvastatin, a standard antilipidaemic drug. The antioxidant potential of the condiment was also examined using different relevant in vitro assays. Albino rats were divided into six groups (n=5), based on the diet and treatment received. The groups were standard feed (control); FCV supplemented feed; standard feed with tyloxapol administered at the end of the experimental period (tyloxapol control); FCV supplemented feed and tyloxapol at the end of the experimental period; standard feed with fluvastatin sodium (40 mg/kg and 80 mg/kg body weight separately) followed by tyloxapol. The results revealed that administration of tyloxapol induced significant (p < 0.05) increase in total-cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglyceride (TG). These lipid increases were significantly mitigated in groups initially pre-fed with supplemented FCV feed. Plasma TC decreased by 69.38% (p < 0.05); TG by 80.58% (p < 0.05); LDL-C by 7.80% (p < 0.05) and high density lipoprotein cholesterol (HDL-C) levels increased by 78.61% (p < 0.05). FCV showed appreciable antioxidant activities in vitro in a dose dependent manner. Histomorphological examination of the liver suggested that the FCV possessed hepatoprotective potential. These results suggest that FCV consumption may be a possible dietary measure for the control of dyslipidaemia.

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Effect of Oilseed Diets on Plasma Lipid Profile in Albino Rats

Cited by 23 publications

References 12 publications

Palm kernel oil increases the risk of coronary heart disease in rats compared with ghee

Palm kernel oil increases the risk of coronary heart disease in rats compared with ghee

Effect of Different Vegetable Oils (Red Palm Olein, Palm Olein, Corn Oil and Coconut Oil) on Lipid Profile in Rat

Antihyperlipidaemic and Antioxidant Potential of Fermented Citrullus vulgaris Seeds (Thunb.) on Tyloxapol-induced Hyperlipidaemic Rats: A Comparison With Fluvastatin

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