Effect of oleanolic acid for prevention of acute lung injury and apoptosis

Bayülgen, Abdulkerim; Ayan, Erhan; Lt, Gümüş; R, Bozdoğan Arpacı; Mo, Köksel

doi:10.5606/tgkdc.dergisi.2019.15058

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Treatment with OA in acetic acid-induced chronic gastric ulcer model rats resulted in a reduction in lesion area and an increase in mucosal thickness, promoting gastric wound healing [47]. Additionally, OA can prevent acute lung injury induced by peroxynitrite and exerts a significant protective effect on pulmonary fibrosis [48,49]. Another study demonstrated that OA can ameliorate dextran sulphate sodium-induced colitis [50].…”

Section: Pharmacologymentioning

confidence: 99%

Oleanolic acid and its analogues: promising therapeutics for kidney disease

Pan,

Qu,

Shi

et al. 2024

Chin Med

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Kidney diseases pose a significant threat to human health due to their high prevalence and mortality rates. Worryingly, the clinical use of drugs for kidney diseases is associated with more side effects, so more effective and safer treatments are urgently needed. Oleanolic acid (OA) is a common pentacyclic triterpenoid that is widely available in nature and has been shown to have protective effects in kidney disease. However, comprehensive studies on its role in kidney diseases are still lacking. Therefore, this article first explores the botanical sources, pharmacokinetics, derivatives, and safety of OA, followed by a summary of the anti-inflammatory, immunomodulatory, anti-oxidative stress, autophagy-enhancing, and antifibrotic effects of OA and its analogues in renal diseases, and an analysis of the molecular mechanisms, aiming to provide further insights for the development of novel drugs for the treatment of kidney diseases.

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Section: Pharmacologymentioning

confidence: 99%

Oleanolic acid and its analogues: promising therapeutics for kidney disease

Pan,

Qu,

Shi

et al. 2024

Chin Med

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Oleanolic acid suppresses pentylenetetrazole-induced seizure in vivo

Türel

Yunusoğlu

2023

International Journal of Environmental Health Research

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Phytochemical study of the contents of Duralabhadi yoga, Vasa and Kantakari extract

Baloni,

Upadhyay

2024

J Drug Res Ayurvedic Sci

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BACKGROUND: Asthma is the most common chronic disease in children, imposing a consistent burden on the healthcare system. In Ayurveda, many formulations are described for managing Shwasa (respiratory disease) and Kasa (cough). Duralabhadi yoga is one of them, which is classically mentioned in Yogaratnakar, Balarogachikitsha, for the treatment of Shwasa (respiratory disease) and Kasa (cough). The present study aimed to identify the phytoactive components of Duralabhadi yoga, as well as the extracts of Vasa and Kantakari, and to learn more about how these phytoactive components affect the human respiratory system, particularly in the cases of childhood asthma. METHODS: For each of the content of Duralabhadi yoga samples and Vasa and Kantakari samples, a high resolution—liquid chromatography mass spectrometry analysis was conducted, and the phytochemical components were identified. Following that, it was determined which constituents impacted asthma and the human respiratory system with the aid of earlier research on these well-known phytochemicals available in databases like PubMed and ChEMBL. RESULTS: In Duralabha sample, 15 compounds have various effects on the respiratory system. 11 compounds have pharmacological action on the respiratory system in the sample of Pippali. In the sample of Haritaki 12 compounds have pharmacological action on the respiratory system. Sixteen compounds each have various effects on the respiratory system in Draksha and Vasa sample. Nine compounds have pharmacological action on the respiratory system in the sample of Kantakari. CONCLUSIONS: The phytoactive compounds found in Vasa, Kantakari, and the various contents of Duralabhadi yoga formulation have the effects of being bronchodilator, anti-inflammatory, antitussive, and anti-allergic.

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Effect of oleanolic acid for prevention of acute lung injury and apoptosis

Cited by 3 publications

References 24 publications

Oleanolic acid and its analogues: promising therapeutics for kidney disease

Oleanolic acid and its analogues: promising therapeutics for kidney disease

Oleanolic acid suppresses pentylenetetrazole-induced seizure in vivo

Phytochemical study of the contents of Duralabhadi yoga, Vasa and Kantakari extract

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