Effect of olfactory bulbectomy on adenylyl cyclase activity in the limbic system

Wann, Boubacar Pasto; D'Anjou, Brian; Bah, Thierno Madjou; Webster, Harry H.; Rousseau, Guy

doi:10.1016/j.brainresbull.2008.12.008

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…The reduction in 5-HT2A levels is also in concordance with another study comparing suicide versus non-suicide schizophrenia subjects using also Affymetrix microarrays [33], suggesting that this reduction in 5-HT2A levels might be involved in suicide irrespective of the diagnosis. We also observed decreased expression in suicide group of the brain specific ADCY1, a brain specific form of adenylate cyclase, suggesting altered neurotransmission and cyclic AMP signaling in suicide and confirms previous observations pointing to cAMP signaling alterations in suicide and mood disorders [60]–[63] and in animal models of depression [64]. Both serotonergic alterations and second messenger systems underline global neurotransmission alterations in the DLPFC that seem to play a role in the predisposition to commit suicide.…”

Section: Discussionsupporting

confidence: 89%

Gene Expression Changes in the Prefrontal Cortex, Anterior Cingulate Cortex and Nucleus Accumbens of Mood Disorders Subjects That Committed Suicide

et al. 2012

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Suicidal behaviors are frequent in mood disorders patients but only a subset of them ever complete suicide. Understanding predisposing factors for suicidal behaviors in high risk populations is of major importance for the prevention and treatment of suicidal behaviors. The objective of this project was to investigate gene expression changes associated with suicide in brains of mood disorder patients by microarrays (Affymetrix HG-U133 Plus2.0) in the dorsolateral prefrontal cortex (DLPFC: 6 Non-suicides, 15 suicides), the anterior cingulate cortex (ACC: 6NS, 9S) and the nucleus accumbens (NAcc: 8NS, 13S). ANCOVA was used to control for age, gender, pH and RNA degradation, with P≤0.01 and fold change±1.25 as criteria for significance. Pathway analysis revealed serotonergic signaling alterations in the DLPFC and glucocorticoid signaling alterations in the ACC and NAcc. The gene with the lowest p-value in the DLPFC was the 5-HT2A gene, previously associated both with suicide and mood disorders. In the ACC 6 metallothionein genes were down-regulated in suicide (MT1E, MT1F, MT1G, MT1H, MT1X, MT2A) and three were down-regulated in the NAcc (MT1F, MT1G, MT1H). Differential expression of selected genes was confirmed by qPCR, we confirmed the 5-HT2A alterations and the global down-regulation of members of the metallothionein subfamilies MT 1 and 2 in suicide completers. MTs 1 and 2 are neuro-protective following stress and glucocorticoid stimulations, suggesting that in suicide victims neuroprotective response to stress and cortisol may be diminished. Our results thus suggest that suicide-specific expression changes in mood disorders involve both glucocorticoids regulated metallothioneins and serotonergic signaling in different regions of the brain.

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Section: Discussionsupporting

confidence: 89%

Gene Expression Changes in the Prefrontal Cortex, Anterior Cingulate Cortex and Nucleus Accumbens of Mood Disorders Subjects That Committed Suicide

et al. 2012

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OBscure but not OBsolete: Perturbations of the frontal cortex in common between rodent olfactory bulbectomy model and major depression

Rajkumar

Dawe

2018

Journal of Chemical Neuroanatomy

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Correlation between Bipolar Affective Disorder and Suicide reviewing by the risk factors: a systematic review

Souza¹,

Ferreira²,

Oliveira³

et al. 2015

Int Arch Med

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Background: Because there are several reports associations between affective (AD) and bipolar disorder (BD) and suicide, the research develops a discussion of risk factors that influence the occurrence of suicide attempts in patients with BD. Objectives:To relate risk factors present in patients with bipolar disorder who committed suicide or some suicide attempt. Methods:A survey was made in Scopus with the keyword "bipolar" and the terms "suicide" and "attempted"and "risk factors" from Medical Subject Headings (MeSH). We use only Scopus as the data source, and the statistical information available in tables and graphs provided from this source. Results:Frequently the AD and BD were associated with suicide occurrence in the studies included in this review. They identified the main risk factors for suicide the previous suicide attempt and hopelessness. The main risk factors for nonfatal suicidal behavior included family history of suicide, early onset of bipolar disorder, extent of depressive symptoms, increasing severity of affective episodes, the presence of mixed affective states, rapid cycling, comorbid Axis I disorders, and abuse of alcohol or drugs. The suicide rate in this disorder reaches three times compared with other mental illnesses, and there are several risk factors: 3:1 ratio of suicide in men compared to women, but in females a greater number of attempts are observed. 25% of persons consume alcohol prior to suicidal attempt. The studies relate these factors and show how they can pose a risk to the carrier of the disorder. There are other risk factor for BD discussed on this review. IntroductionBipolar affective disorder (BD) is characterized by episodes of depression and hypomania and / or mania. BD has been responsible for the higher rate of suicidal behavior compared to any other mental disorder [1,2]. It is a potentially lethal disease with a high risk of suicide completed, which again is associated with a history of suicide attempts [2]. During life, about 61% of patients with BD experiencing suicidal ideation, 25% to 56% will attempt suicide, and between 10% and 19% die from suicide2. Several studies suggest that previous suicide attempts of bipolar patients may indicate that they are over than 50% more likely to complete suicide [2]. A better understanding of the characteristics and risk factors related to suicide attempts is the first step to prevent future attempts and early detection of risk patients [1,2].Suicide is a tragic potential outcome for patients with bipolar disorder, and unfortunately, this event is not uncommon. Twenty-five percent to 50% of all bipolar patients have been found to attempt suicide at leart once in their lifetime, with 11% to 19% of bipolar patients eventually dying of suicide and standardized mortality ratio for suicide of 12.3 [3-7].There is evidence that suicide rates among mood disorder patients are more than 20-fold higher than in the general population and that suicidal behavior is much more lethal in bipolar disorder than in the general populati...

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Effect of olfactory bulbectomy on adenylyl cyclase activity in the limbic system

Cited by 3 publications

References 21 publications

Gene Expression Changes in the Prefrontal Cortex, Anterior Cingulate Cortex and Nucleus Accumbens of Mood Disorders Subjects That Committed Suicide

Gene Expression Changes in the Prefrontal Cortex, Anterior Cingulate Cortex and Nucleus Accumbens of Mood Disorders Subjects That Committed Suicide

OBscure but not OBsolete: Perturbations of the frontal cortex in common between rodent olfactory bulbectomy model and major depression

Correlation between Bipolar Affective Disorder and Suicide reviewing by the risk factors: a systematic review

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