Effect of olive oil phenols on the production of inflammatory mediators in freshly isolated human monocytes

<i>Olea europaea</i> Linn (Oleaceae) Fruit Pulp Extract Exhibits Potent Antioxidant Activity and Attenuates Neuroinflammatory Responses in Lipopolysaccharide- Stimulated Microglial Cells

“…Previous studies on tumor cell lines in vitro and animal models in vivo revealed that the olive oil and leaf extracts might be helpful in suppressing inflammatory conditions [9,10]. The phenolic antioxidant compounds present in Olive oil extracts were also reported to show antiinflammatory properties [17].…”

“…As a folk remedy, olives have been used to reduce the incidence of heart diseases [8]. Experimental studies on the fruits and leaf extracts from olives show that they possess anti-thrombotic, antihypertensive, anti-cancer, hypoglycemic, antiinflammatory, anti-microbial and anti-atherogenic properties [9,10]. The major active components of olives are phenolic constituents including oleuropein, hydroxytyrosol, tyrosol, 4-hydroxyphenyl acetic acid, protocatechuic acid, caffeic acid and p-coumaric acid.…”

“…Although the health beneficial effects of olive fruit and leaf oils have been confirmed in vitro using different cell lines [10], studies on the olive fruit pulp extracts and their protective effect on neuroinflammatory conditions using microglial cells have not been demonstrated. In the present study the ethyl acetate fraction obtained from olive fruit pulp extract (OFP-EA) was investigated for its anti-neuroinflammatory effects in LPSstimulated BV-2 microglial cells and the antioxidant property was also evaluated to substantiate its anti-neuroinflammatory effects.…”

Development and Validation of RP-HPLC-DAD Method to Quantify Hydroxytyrosol Content in a Semi-Solid Pharmaceutical Formulation

“…EVOO contains a large number of phenolic compounds, including phenolic acids, phenolic alcohols such as tyrosol and hydroxytyrosol, flavonoids, and secoiridoids that may contribute to its overall health benefits together with monounsaturated fatty acids, squalene and α-tocopherol [8][9][10][11]. Polyphenols, in particular, exhibit potent free radical-scavenging properties and a range of biological activities e.g., antimicrobial, anti-carcinogenic and anti-inflammatory responses [12].…”

<i>Olea europaea</i> Linn (Oleaceae) Fruit Pulp Extract Suppresses Sterol Regulatory Element-Binding Proteins-1c via AMP-Activated Protein Kinase Activation in Human Hepatic Cells

“…Olives and its associated products have been used widely as folk medicines [5]. Experimental studies on the fruits and leaf extracts from olives show that they possess anti-thrombotic, antihypertensive, anti-cancer, hypoglycemic, antiinflammatory, anti-microbial and antiatherogenic properties [6,7]. The major active components of olives are phenolic constituents [8,9 ].…”