Effect of one-anastomosis gastric bypass on cardiovascular risk factors in patients with vitamin D deficiency and morbid obesity: A secondary analysis

Abstract

Background and aims: Bariatric patients often suffer from vitamin D (VD) deficiency, and both, morbid obesity and VD deficiency, are related to an adverse effect on cardiovascular disease (CVD) risk. Therefore, we assessed the change of known CVD risk factors and its associations during the first 12 months following one-anastomosis gastric bypass (OAGB). Methods and results: In this secondary analysis, CVD risk factors, medical history and anthropometric data were assessed in fifty VD deficient (25-hydroxy-vitamin D (25(OH)D) <75 nmol/l) patients, recruited for a randomized controlled trial of VD supplementation. Based on previous results regarding bone-mass loss and the association between VD and CVD risk, the study population was divided into patients with 25(OH)D !50 nmol/l (adequate VD group; AVD) and into those <50 nmol/l (inadequate VD group; IVD) at 6 and 12 months (T6/12) postoperatively. In the whole cohort, substantial remission rates for hypertension (38%), diabetes (30%), and dyslipidaemia (41%) and a significant reduction in CVD risk factors were observed at T12. Changes of insulin resistance markers were associated with changes of total body fat mass (TBF%), 25(OH)D, and ferritin. Moreover, significant differences in insulin resistance markers between AVD and IVD became evident at T12. Conclusion: These findings show that OAGB leads to a significant reduction in CVD risk factors and amelioration of insulin resistance markers, which might be connected to reduced TBF%,

Are the European Society of Cardiology guidelines on lipid-lowering treatment implemented in morbidly obese patients qualified for bariatric surgery?

“…The average levels of LDL-C and TG presented in our article (2.66 and 1.28 mmol/l, respectively) are lower than the values reported in a similar study from Austria (3.12 and 1.78 mmol/l) [6], Singapore (3.05 and 1.66) [7], and the US (2.88 and 1.74 mmol/l ) [10]. Conversely, serum levels of non-HDL-C in the Austrian study (3.9), and total cholesterol shown in the Singaporean investigation (4.9 mmol/l) were lower than those quoted in our article (3.16 and 4.3 mmol/l, respectively).…”

The Effect of Bariatric Surgery on Circulating Levels of Lipoprotein (a): A Meta-analysis

“…Another study assessed Lp(a) by chemiluminescent immunoassays [ 50 ], and one study used the Cobas Mira Plus (Roche Diagnostics) analyzer [ 38 ]. In seven studies, the method was not specifically mentioned [ 39 – 42 , 45 , 48 , 49 ].…”

Actualización en el abordaje de hipovitaminosis D en población obesa.

“…Pre-operatoriamente, un 50-96% de los pacientes bariátricos presenta hipovitaminosis D, sin embargo, esta situación es evidentemente empeorada en el post-operatorio debido a la restricción gástrica y la malabsorción secundaria a la cirugía (28). Esta situación predomina en el procedimiento de Roux-en-Y, en la cual se reseca la porción proximal del intestino delgado, en donde se da la mayor absorción de vitamina D (1,29).…”