Effect of oral dosing vehicles on the developmental toxicity of flubendazole in rats

Yoshimura, Haruo

doi:10.1016/s0890-6238(03)00033-9

Cited by 17 publications

(11 citation statements)

References 18 publications

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“…(46)(47)(48)(49)(50)(51) Several prescription drugs, including calcium valproate, acetazolamide, suramin and flubendazole, have also been found to cause body-wallrelated abnormalities in rodents and avians. (52)(53)(54)(55) Given that these substances cause embryotoxicity in rodents and/or chickens, the same birth defects have been inferred in pregnant women. Clearly, however, rodent, avian and human embryos may not be affected in equivalent ways by the same environmental agent.…”

Section: Normal Development Of the Ventral Body Wall In Humansmentioning

confidence: 92%

Finally, a sense of closure? Animal models of human ventral body wall defects

2004

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Malformations concerning the ventral body wall constitute one of the leading categories of human birth defects and are present in about one out of every 2000 live births. Although the occurrence of these defects is relatively common, few detailed experimental studies exist on the development and closure of the ventral body wall in mouse and human. This field is further complicated by the array of theories on the pathogenesis of body wall defects and the likelihood that there is no single cause for these abnormalities. In this review, we summarize what is known concerning the mechanisms of normal ventral body wall closure in humans and mice. We then outline the theories that have been proposed concerning human body wall closure abnormalities and examine the growing number of mouse mutations that impact normal ventral body wall closure. Finally, we speculate how studies in animal models such as mouse and Drosophila are beginning to provide a much-needed mechanistic framework with which to identify and characterize the genes and tissues required for this vital aspect of human embryogenesis.

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Section: Normal Development Of the Ventral Body Wall In Humansmentioning

confidence: 92%

Finally, a sense of closure? Animal models of human ventral body wall defects

2004

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“…1), the maximum residue limits were established in Korea as a result of the potential for nontarget toxicity. Several side effects of these benzimidazoles were reported in studies with rodents and birds, such as the developmental toxicity potential of thiabendazole and flubendazole [9,10], toxicosis after fenbendazole and albendazole exposure [11], and testicular toxicity of oxfendazole [12]. However, very limited data are available regarding potential benzimidazole hazards to aquatic receptors.…”

Section: Introductionmentioning

confidence: 99%

Ecological hazard assessment of major veterinary benzimidazoles: Acute and chronic toxicities to aquatic microbes and invertebrates

Park

Lee

et al. 2006

Environmental Toxicology and Chemistry

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Aquatic toxicities of six benzimidazole-based anthelmintics-namely, albendazole, thiabendazole, flubendazole, febantel, fenbendazole, and oxfendazole-were evaluated with a marine bacterium, Vibrio fischeri, and a freshwater invertebrate, Daphnia magna. Delayed and chronic toxicity tests using D. magna also were conducted for benzimidazoles with high acute toxicity. Vibrio fischeri was greater than 10-fold less sensitive to most of the benzimidazoles tested compared to daphnids. For D. magna, the most acutely toxic anthelmintic compound tested was fenbendazole (48-h median effective concentration [EC50s], 16.5 microg/L), followed by flubendazole (48-h EC50, 66.5 micro/L), albendazole (48-h EC50, 67.9 microg/L), febantel (48-h EC50, 216.5 microg/L), thiabendazole (48-h EC50, 843.6 microg/L), and oxfendazole (48-h EC50, 1,168.4 microg/L). The lipophilicity parameter, log Kow, explained the observed acute D. magna toxicity of the individual benzimidazoles (r = -0.91, p < 0.01). Delayed expression of toxicity observed for 21 d after 96-h exposure to fenbendazole and flubendazole was not notable, which might result from the relatively high elimination constants for the chemicals. With chronic exposure to fenbendazole, D. magna survival, reproduction, and growth were significantly impacted at 1.25 to 4.1 microg/L (p < 0.05). Hazard quotients estimated for fenbendazole, albendazole, flubendazole, and febantel were 2,770, 9.7, 4, and 1.2, respectively, suggesting a need for further investigation and a potential for environmental concerns, particularly with fenbendazole.

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“…Some chemicals have been reported to exhibit higher toxicity when administered in oily vehicles than in aqueous vehicles (Yoshimura, ). Besides this, we must be especially careful with the different designs, in experiments that include reproductive parameters, as these may influence the final response of the research.…”

Section: Discussionmentioning

confidence: 99%

Influence of mineral, olive or sunflower oils on male reproductive parametersin vitro -the wild rodentCalomys laucha

et al. 2013

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The aim of this study was to evaluate the influence of oils on male reproductive parameters in Calomys laucha. Twenty-four animals were distributed into four groups and given the following substances by gavage: water, mineral oil, olive oil and sunflower oil. After 10 days of gavage, the animals were euthanised and the semen was collected from them for assessing acrosome integrity and carrying out in vitro penetration (IVP) test. Acrosome was significantly reduced (P < 0.05) for the vehicles in relation to control. In vitro penetration was reduced in all vehicles in relation to control, but only sunflower oil had statistically lower levels of reduction (P < 0.05). Oily vehicles are able to influence in vitro reproductive tests negatively, interfering in reproductive toxicological studies.

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Effect of oral dosing vehicles on the developmental toxicity of flubendazole in rats

Cited by 17 publications

References 18 publications

Finally, a sense of closure? Animal models of human ventral body wall defects

Finally, a sense of closure? Animal models of human ventral body wall defects

Ecological hazard assessment of major veterinary benzimidazoles: Acute and chronic toxicities to aquatic microbes and invertebrates

Influence of mineral, olive or sunflower oils on male reproductive parametersin vitro -the wild rodentCalomys laucha

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