Effect of oral gabapentin on haemodynamic variables during microlaryngoscopic surgery

Abstract

800 mg oral gabapentin given 90 min before a procedure attenuates the rise of diastolic blood pressure and mean arterial blood pressure in the first 15 min after microlaryngoscopy surgery, but has no effect on systolic blood pressure or heart rate.

Gabapentin as Premedication for Postoperative Analgesia in Children: A Prospective Randomized Controlled Study

“…They found that gabapentin is effective in reducing the painful stimuli during laryngoscopy and intubation, hence attenuating the haemodynamic response which correspondent to our study [22].…”

Efficacy of preoperative oral gabapentin for patients undergoing intracranial surgery: Effect on laryngoscopic stress response

“…Ayatollahi and his colleagues have reported that administration of 800 mg of oral gabapentin 1.5 hours prior to surgery was effective in the attenuation of both diastolic and mean arterial pressure. However, both systolic blood pressure and heart rate were not significantly affected [12].…”

Effect of dexmedetomidine infusion on hemodynamic responses in microsurgery of larynx

“…Various drugs such as propofol,[ 8 9 ] sevoflurane,[ 9 ] oral clonidine,[ 10 ] lignocaine spray,[ 2 ] β-blockers,[ 11 ] and oral gabapentin[ 12 ] have been used in various combinations and doses to ameliorate this hyperdynamic response to MLScopy. However, a delayed postoperative awakening with propofol, delayed onset of action with oral clonidine and gabapentin and an increased incidence of complications secondary to myocardial depression with β-blockers were faced.…”