Abstract:This study was conducted to evaluate the oral absorption of enrofloxacin (ENFX) in rats when administered with orange oil or its main component, limonene. Compared with the group administered ENFX alone, the ENFX + limonene group did not show any significant difference in the absorption of ENFX, whereas the extent and rate of absorption of ENFX were significantly decreased in the ENFX + orange oil group (C max , -43%; T max , 129%). In addition, t 1/2λz and MRT of ENFX were prolonged by the concomitant adminis… Show more
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