Effect of organic ligands with conjugated π‐bonds on the structure of iodine–α‐dextrin complexes

Abstract

Using X-ray data for iodine-α-dextrin complexes and the results of quantum chemical ab initio restricted Hartree-Fock/3-21G(**) level calculations, a model of drug active complex (AC) Armenicum with anti-HIV action was proposed. It was suggested that the drug AC contains molecular iodine allocated inside of α-dextrin helix and coordinated by lithium halogenides and a protein component of lymphocyte ribosomes. The electronic structure of I(2) in this complex differs from its characteristics in complexes with organic ligands or the free I(2) . In the considered ACs, the molecular iodine displays acceptor (donor) properties toward the α-dextrins (lithium halogenides). A mechanism of Armenicum anti-HIV action is suggested. Under the influence of molecular iodine-containing drug AC, the structure of HIV DNA is modified-it becomes more π-donor-active against proteins and peptide nucleotides of viral DNA form a stable complex with molecular iodine and lithium halogenides.

Action Mechanism of Molecular Iodine Complex with Bioorganic Ligands, Magnesium and Lithium Halogenides on Human Tuberculosis Strain With Multiple Drug Resistance

“…Only bioorganic ligands can compete with I 2 for complex formation as their donor activity towards iodine is higher of peptides. In our articles using quantum-chemical methods we have shown that only DNA nucleotides can compete with peptides for iodine complex formation [14]. UV-spectrum interpretation of aqueous solution, which contains FS-1 and nucleotide triplet, using TD-DFT/ B3PW91 method indicates that nucleotides replace peptides from LiCl(I)I 2 polypeptdex complex and form the complex with molecular iodine and lithium halogenide [15].…”

Subchronic Toxicity of the New Iodine Complex in Dogs and Rats

“…It contains polysaccharides and polypeptides derived from hydrolyzed albumin which form a strong complex with iodine molecules. This makes possible to minimize the interaction of iodine with proteins present in the gastrointestinal tract, without significantly reducing pharmacological activity (11)(12)(13). It was previously shown in vitro and during the research on in mice that complexes of iodine with polypeptides and dextrin, in combination with doxorubicin, possess a potentiation effect (14,15).…”

The effect of the amphoteric properties of amino acids in the zwitterionic form on the structure of iodine complex compounds in aqueous solutions

“…A broad spectrum of antimicrobial applications, including anti HIV-infection, and the high therapeutic efficacy of iodinecontaining drugs justify the need of physicochemical and structural research on model iodine complex compounds [1][2][3][4][5][6].…”

“…Low toxicity and the possibility of parenteral and enteral introduction are observed only in the ''Armenicum'' drug and the newly developed anti-infectious drug (AP) [1][2][3][4][5][6].…”