Purpose: The purpose of this study is to investigate the effect of both work to family enrichment and family to work enrichment on family satisfaction and work satisfaction. The moderating role of positive and negative affectivity is also examined in this regard. Methodology: This Study is an empirical survey research with the statistical population of faculty members of Iran's universities. The research questionnaires were distributed among professors of five premier universities of Tehran. 200 people were used by simple random sampling. Carlson et al. (2000), Carlson, Kacmar, and Williams (2000), Brayfield and Crockett (1955), Schumm, McCollum, Bugaighis, Jurich, and Bollman (1986) and Agho et al. (1992) questionnaires were used and research hypotheses were tested through structural equation modeling by PLS software. Findings: The results showed that according to path coefficient, work family enrichment has a positive and significant effect on faculty members' job satisfaction (0.7562) and family satisfaction (0.7362) both T-statistics are upper than 1.96. Positive affectivity enhances these relationships as a moderating variable (0.6423). However, negative affectivity had no significant effect on the relationship between work family enrichment and family and job satisfaction (both T-statistics are lower than 1.96). Conclusion: positive aspects of work family interface, in other words, work family enrichment in comparison with work family conflict variable should be considered as an important variable in psychology of family and organization. The issue of work family enrichment in the scientific jobs of faculty members of universities which have distinctive job qualifications compared with other jobs could have a significant effect in job and family satisfaction.