Effect of organophosphate pesticide Sumithion (Fenitrothion) on some aspects of carbohydrate metabolism in a freshwater fish,Sarotherodon (Tilapia)mossambicus (Peters)

Abstract

A lethal (Lc50/48 h - 6 mg/l) concentration of the organophosphate (OP) pesticide Sumithion increased blood glucose levels and phosphorylase activity, but hepatic glycogen registered a fall which indicated that the observed hyperglycemia was due to breakdown of hepatic glycogen.

Effects of Sublethal Doses of Fenvalerate (A Synthetic Pyrethroid) Administered Continuously for Four Weeks on the Blood, Liver, and Muscles of a Freshwater Fish, Ctenopharyngodon idella

“…Sastry and Siddiqui (1984) reported increase in the glycogen content of liver and muscle of Channa punctutus after exposure to quinalphos. Contrary to that and in agreement with the present results Koundinya and Ramamurthi (1979) observed hyperglycemia accompanied by decrease in the glycogen content of liver and muscle of Sarotherodon mossambica after treatment with fenitrothion.…”

Reversible hyperglycemia in rats following acute exposure to acephate, an organophosphorus insecticide: Role of gluconeogenesis

“…Fenitrothioninduced increase in blood glucose in S. mossambicus was associated with decreased hepatic glycogen (Koundinya and Ramamurthi, 1979) and sub chronic exposure of rats to acephate, which caused slight increase in blood glucose, also caused depletion of liver glycogen (Deotare and Chakrabarti, 1981). Abdollahi et al (2004a) reported increased activity of GP and phosphoenolpyruvate carboxykinase (PEPCK) following sub chronic exposure to Malathion.…”

“…Fenitrothion and fenthion have been shown to increase blood glucose levels in S. mossambicus, a fresh water fish (Koundinya and Ramamurthi, 1979) and H. fossilis, a teleost fish (Srivastava and Mishra, 1983), respectively following acute exposure. Acute exposure to malathion (Matin and Hussain, 1987;Panahi et al, 2006) and diazinon (Hussain and Ansari, 1988;Matin et al, 1989) has also been shown to be associated with elevated blood glucose in rats.…”

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

“…Figure 2 illustrates how disturbances in the histoarchitecture of the liver induced by OPs can affect its performance in the enzymatic pathways involved in the metabolism of lipids, carbohydrates, and proteins in the cytoplasm, mitochondria, and peroxisomes (9). Animal studies suggest that the activity of glycogen phosphorylase (GP), the enzyme that breaks glycogen into glucose and reduces the hepatic glycogen content, increases after fenitrothion and malathion exposure (74,75). This is supported by a drop in hepatic glycogen concentration after fenthion exposure in fish (76).…”