Effect of oropharyngeal decontamination by povidone-iodine on ventilator-associated pneumonia in patients with head trauma*

Séguin, Philippe; Tanguy, M.; Laviolle, Bruno; Tirel, O.; Mallédant, Yannick

doi:10.1097/01.ccm.0000214516.73076.82

Cited by 93 publications

(72 citation statements)

References 37 publications

(68 reference statements)

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“…Providoneiodine and iseganan have only been evaluated in one trial each. The providone-iodine trial showed a decrease in VAP rates but no impact on patient outcomes [62]. The trial of iseganan showed no impact on either VAP rates or patient outcomes [63].…”

Section: Oral Antiseptics and Antibioticsmentioning

confidence: 99%

Prevention of ventilator-associated pneumonia

Klompas¹

2010

Expert Review of Anti-infective Therapy

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Section: Oral Antiseptics and Antibioticsmentioning

confidence: 99%

Prevention of ventilator-associated pneumonia

Klompas¹

2010

Expert Review of Anti-infective Therapy

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“…For example, chlorhexidine is employed because of its high level of antibacterial, antiviral, and antifun-gal activities and high substantivity (ability to bind to oral tissues with subsequent slow release of antiseptic properties and therefore a long period of antibacterial action). 8,9 Although generally safe, chlorhexidine is not free of adverse events.…”

Section: Introductionmentioning

confidence: 99%

Effect of Oral Hygiene and 0.12% Chlorhexidine Gluconate Oral Rinse in Preventing Ventilator-Associated Pneumonia After Cardiovascular Surgery

et al. 2013

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BACKGROUND: Ventilator-associated pneumonia (VAP) is a nosocomial infection of multifactorial etiology and has a negative influence on cardiovascular surgery (CVS) outcomes. OBJECTIVES: Determine the effect of toothbrushing plus 0.12% chlorhexidine gluconate oral rinse in preventing VAP after CVS. METHODS: In a quasi-experimental study, patients undergoing heart surgery were enrolled in a protocol for controlling dental biofilm by proper oral hygiene (toothbrushing) and oral rinses with 0.12% chlorhexidine gluconate (Group 1), and they were compared with a historical control group (Group 2), which included patients who underwent cardiac surgery be-

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“…Antiseptik yang sering digunakan adalah povidone iodine dan chorhexidine. Seguin (2006) meneliti 98 klien trauma kepala dengan Glasgow Coma Score ≤8 dan ventilator ≥2 hari. Sample dibagi dalam 3 kelompok yaitu povidone iodine n=36, saline group n=31 dan kelompok kontrol n=31, menyimpulkan bahwa povidone iodine sebagai strategi yang efektif untuk menurunkan prevalensi ventilator-associated pneumonia (VAP) pada klien tauma kepala berat.…”

Section: Komponen Kekebalanunclassified

Perbandingan Oral Care Menggunakan Povidone Iodine 1% dengan Chlorhexidine 0.2% terhadap Jumlah Bakteri di Mulut pada Pasien Penurunan Kesadaran

Widani¹,

Nasution²

2015

JKP

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AbstrakOral care klien penurunan tingkat kesadaran tidak boleh diabaikan dan membutuhkan antiseptik oral yang mempunyai sifat antibakteri. Penelitian ini adalah penelitian kuantitatif dengan desain quasi eksperimen dengan kelompok kontrol, pre dan post test untuk mengidentifikasi perbandingkan povidone iodine 1% dengan chlorhexidine 0.2% terhadap jumlah koloni bakteri di mulut klien penurunan kesadaran. Hasil penelitian pada 30 responden yang diambil secara consecutive sampling dibagi tiga kelompok. Ada perbedaan yang signifikan penurunan jumlah koloni bakteri sebelum dan setelah oral care pada povidone iodine (p=0.007), chlorhexidine (p=0.001) dan air (p=0.001). Perbandingan selisih jumlah bakteri antara povidone iodine 1%, chlorhexidine 0.2% dan kontrol tidak signifikan (p=0,343). Disimpulkan chlorhexidine 0.2% , povidone iodine 1% dan air minum masing-masing mempunyai kemampuan yang signifikan menurunkan koloni bakteri dan dapat digunakan sebagai pembilas oral care. Disarankan secara ekonomis air minum digunakan dalam oral care apabila klien penurunan kesadaran tidak mengalami infeksi mulut, dan chlorhexidine 0.2% atau povidone iodine 1% digunakan bila ada infeksi mulut.Kata kunci: Chlorhexidine 0.2%, koloni bakteri mulut, oral care, penurunan kesadaran, povidone iodine 1%. The Comparison of Oral Care Using Povidone-iodine 1% and Chlorhexidine 0.2% to the Amount of Bacteria on the Patients with Altered State of Consciousness AbstractThe oral care of unconscious patients should not be ignored and requires oral antiseptics that have antibacterial properties. This research was a quasi-experimental design with control groups, using pre-post test design. The study was aimed to compare the amount of bacteria colonies after oral care using povidone iodine 1% and chlorhexidine 0.2% on the patients with altered state of consciousness. Using consecutive sampling technique, 30 eligible respondents were divided into three groups. The results of this study identified that there was a significant decreased of the amount of bacteria colonies after oral care using povidone iodine (p= 0.007), chlorhexidine (p=0.001) and water oral care (p=0.001). The difference of the number of colonies for oral care using povidone iodine 1%, chlorhexidine 0.2%, and the control group was not significant (p=0.343). It can be concluded that each of oral care using chlorhexidine0.2%, povidone iodine 1% and water has a significant ability to reduce colonies of bacteria and can be used as an oral care. For economic reason, it was advised to use water for oral care if clients do not experience oral infections, and to use chlorhexidine 0.2% or povidone iodine 1% when there is infection of the mouth.

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Effect of oropharyngeal decontamination by povidone-iodine on ventilator-associated pneumonia in patients with head trauma*

Abstract: The regular administration of povidone-iodine may be an effective strategy for decreasing the prevalence of ventilator-associated pneumonia in patients with severe head trauma.

Cited by 93 publications

References 37 publications

Prevention of ventilator-associated pneumonia

Prevention of ventilator-associated pneumonia

Effect of Oral Hygiene and 0.12% Chlorhexidine Gluconate Oral Rinse in Preventing Ventilator-Associated Pneumonia After Cardiovascular Surgery

Perbandingan Oral Care Menggunakan Povidone Iodine 1% dengan Chlorhexidine 0.2% terhadap Jumlah Bakteri di Mulut pada Pasien Penurunan Kesadaran

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