Effect of ovariectomy in bone structure of mandibular condyle

Constâncio, Cristina; Pagani, Bruna Trazzi; Azevedo, Regina Magrini Guedes de; Grion, Dalva Pazzini; Marques, Leonardo; Kinoshita, Ângela

doi:10.1590/s0102-865020170100000006

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…Animals were randomly divided into the following groups: Group 1 (control): Sham ovariectomy group (n = 10). Rats in this group underwent the same surgical steps of ovariectomy without surgical removal of the ovaries, the ovaries were lifted up and returned to their original position [11]. They were housed in standard cages (28 x 40) with the same cagemates and fed on standard laboratory rat chow 1 for the whole 8 weeks duration of the study.…”

Section: Experimental Animals and Groupsmentioning

confidence: 99%

The cross-talk between matrix metalloproteinase-9, RANKL/OPG system and cardiovascular risk factors in ovariectomized rat model of postmenopausal osteoporosis

et al. 2021

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Epidemiology and pathogenesis of cardiovascular diseases (CVD) and osteoporosis are strikingly overlapping. This study presents matrix metalloproteinase-9 (MMP-9), as a simple molecular link more consistently associated with the pathophysiology of both osteoporosis and CVD risk factors. 40 adult female rats were randomly distributed into 4 groups [control sham-operated, untreated osteoporosis, carvedilol-treated osteoporosis and alendronate-treated osteoporosis]. After 8 weeks, blood samples were collected to estimate Lipid profile (Total cholesterol, HDL, Triglycerides), inflammatory markers (IL-6, TNF alpha, CRP and NO), and Bone turnover markers (BTM) (Alkaline phosphatase, osteocalcin and pyridinoline). The tibias were dissected to estimate MMP-9 and NF-kB gene expression, OPG, RANKL levels and for histological examination. Induction of osteoporosis resulted in a significant elevation in BTM, inflammatory markers and dyslipidemia. MMP-9 was significantly elevated and positively correlated with BTM, inflammation and dyslipidemia markers. Carvedilol and alendronate exerted a bone preservative role and attenuated dyslipidaemia and inflammation in accordance with their respective effect on MMP-9.

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Section: Experimental Animals and Groupsmentioning

confidence: 99%

The cross-talk between matrix metalloproteinase-9, RANKL/OPG system and cardiovascular risk factors in ovariectomized rat model of postmenopausal osteoporosis

et al. 2021

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“…As a rule, studies are fragmentary and conducted on an inconsiderable amount of objects without consideration of correlative interrelations of the internal female reproductive organs with the adjacent organs at different terms of perinatal period. Therefore, the study within the frame of perinatal anatomy of ovaries is topical and timely [3][4][5][6]8].…”

Section: Introductionmentioning

confidence: 99%

Ovarian characteristics in the fetal period: topographic and morphometric parallels

Проняєв

Bulyk

2019

Biomed. and Biosoc. Anthrop.

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Defects of the urinary system take the 3rd place by their occurrence including 6% of developmental defects of the female reproductive organs. Therefore modern studies in the field of perinatal anatomy are of a special importance. Objective of the study was to determine age peculiarities in the structure and topography of the fetal ovaries as well as similar and different tendencies in changes of the ovarian morphological parameters of the two groups of fetuses, remote in time. The study was conducted in the two groups of human fetuses, 4-10 months of development, 161.0-500.0 mm of the parietal-calcaneal length. The first group consisting of 35 specimens divided into 7 subgroups according to the month of development (4, 5, 6, 7, 8, 9 and 10), was formed with fetuses died during 2017-2019 years. The second group included specimens of fetuses collected during 1970-1990. The obtained results were statistically processed in the licensed statistical package “Statistica 6.0”. The character of distribution for every obtained variation lines, mean values for every sign, standard quadratic deviation, percentile scope of the parameters were evaluated. Reliability of differences in the indices between independent quantitative values was determined by means of Mann-Whitney U-criterion. The conducted study determined that the ascending position of the ovaries in the early fetuses can be considered normal for the given age group, though the topography is indicative of developmental retardation at the late stages of perinatal development. The length of the ovary in both groups increases gradually from the 4th to the 10th month with a certain delay during the 6th month. It might be associated with intensified growth of its parenchyma, and intensive increase of its width and length respectively. The majority of the ovarian parameters of 9-10 month fetuses do not differ reliably, which is indicative of a complete development of the ovarian definite structure at the 9th month of the intrauterine development. Comparison of the parameters of the two groups of fetal specimens, remote in time, is indicative of the fact that in the majority of the parameters they do not differ. Although in modern studies the length of the right ovary in 8-month fetuses, and the length of the left ovary in 7-month fetuses is shorter than that of the archival specimens. Similarly the width of the left ovary in 4-month fetuses appears to be reliably shorter than that of the archival specimens. The thickness of the right ovary of 7 and 10-month modern fetuses is reliably less than that of the appropriate groups of the archival specimens. The thickness of the left ovary of modern fetuses is reliably less than that of the archival specimens during the 10th month. Therefore, a reliable difference was found only in 2 pairs of the parameters included in 42 pairs of the examined morphometric parameters of both groups. It is indicative of inconsiderable changes of these parameters during the period of 27-49 years.

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Combination of estrogen deficiency and excessive mechanical stress aggravates temporomandibular joint osteoarthritis in vivo

Kadota-Watanabe

Ogawa

et al. 2019

Archives of Oral Biology

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Effect of ovariectomy in bone structure of mandibular condyle

Cited by 4 publications

References 25 publications

The cross-talk between matrix metalloproteinase-9, RANKL/OPG system and cardiovascular risk factors in ovariectomized rat model of postmenopausal osteoporosis

The cross-talk between matrix metalloproteinase-9, RANKL/OPG system and cardiovascular risk factors in ovariectomized rat model of postmenopausal osteoporosis

Ovarian characteristics in the fetal period: topographic and morphometric parallels

Combination of estrogen deficiency and excessive mechanical stress aggravates temporomandibular joint osteoarthritis in vivo

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