Effect of oxidative modification of activated carbon for the adsorption behavior of nicotine

Pi, Kewu; Xia, Min; Pan, Wei‐Ping; Yang, Meichen; Chen, Shuyu; Liu, Defu; Gerson, Andrea R.

doi:10.1016/j.jiec.2015.06.014

Cited by 27 publications

(9 citation statements)

References 29 publications

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“…At pH 7, the nicotine molecule is predominantly (i.e. 60%) in this monoprotonated state . The positively charged region within the nicotine molecule (i.e.…”

Section: Resultsmentioning

confidence: 99%

“…Within aqueous media at pH 9, the nicotine molecule is primarily (90%) in the neutral form . Under such conditions, the lone pair on the nitrogen atom of the pyridine ring presents a compact region of negative potential.…”

Section: Resultsmentioning

confidence: 99%

“…provide feelings of pleasure, reduced stress and anxiety). The nicotine molecule (3‐(1‐methyl‐2‐pyrollidiniyl)‐pyridine) is considered to be a weak organic base owing to the presence of two nitrogen atoms that function as proton‐acceptor sites . The species is composed of a five‐membered pyrrolidine ring of pKa 8.02 that contains its nitrogen atom in the more basic sp3 configuration and a six‐membered pyridine ring of pKa 3.12 in which the nitrogen atom is in the sp2 configuration .…”

Section: Introductionmentioning

confidence: 99%

“…Variation in the protonation state of this molecule is dependent on solution pH. For example, below pH 3 the diprotonated species exists, between pH 4 and pH 7 the monoprotonated form presents (because of the protonation of N ‐methyl‐pyrrolidine) and above pH 9 nicotine exists as a neutral molecule . Therefore, at physiological pH, the predominant species are the singly protonated pyrrolidinium form and the neutral form .…”

Section: Introductionmentioning

confidence: 99%

“…Variation in the protonation state of this molecule is dependent on solution pH. For example, below pH 3 the diprotonated species exists, between pH 4-7 the monoprotonated form presents (due to the protonation of N-methyl-pyrrolidine) and above pH 9 nicotine exists as a neutral molecule [22].…”

Section: Introductionmentioning

confidence: 99%

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The pH dependent interaction between nicotine and simulated pulmonary surfactant monolayers with associated molecular modelling

Davies

Leach

Fullwood

et al. 2017

Surface & Interface Analysis

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Pulmonary surfactant is an endogenous material that lines and stabilises the alveolar air-liquid interface. Respiratory mechanics can be compromised by exposure to environmental toxins such as cigarette smoke, which contains nicotine. This study aims to determine the influence of nicotine on the activity of simulated lung surfactant at pH 7 and pH 9. In all cases, the addition of nicotine to the test zone caused deviation in surfactant film performance. Importantly, the maximum surface pressure was reduced for each system. Computational modelling was applied to assess key interactions between each species, with the GAUSSIAN 09 software platform used to calculate electrostatic potential surfaces. Modelling data confirmed either nicotine penetration into the two-dimensional structure or interfacial/electrostatic interactions across the underside. The results obtained from this study suggest that nicotine can impair the ability of pulmonary surfactant to reduce the surface tension term, which can increase the work of breathing. When extrapolated to gross lung function, alveolar collapse and respiratory disease (e.g. chronic airway obstruction) may result. The delivery of nicotine to the (deep) lung can cause a deterioration in lung function and lead to reduced quality of life.

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“…At pH 7, the nicotine molecule is predominantly (i.e. 60%) in this monoprotonated state . The positively charged region within the nicotine molecule (i.e.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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