Effect of paracetamol coadministration on aspirin-induced gastrointestinal bleeding in dogs

Paracetamol Confers Resistance to Ethanol-induced Gastric Mucosal Damage in Rats

“…In its selective inhibitory action on prostaglandin synthesis in the brain (Tolman et al 1983), it is also different from NSAIDs which have a profound gastrointestinal-damaging effect in man and in animals (Pfeiffer & Lewandowski 1971; Bartle et al 1986;Hawkey et al 1986). Oral administration of a high dose of paracetamol to rats has been found to antagonize stomach mucosal ulceration by various gastric irritants, such as ethanol, sodium hydroxide, hydrochloric acid and NSAIDs (Seegers et al 1979;Van Kolfschoten et a1 1983); this has not been seen in dogs (Leeling et al 1981) or in man (Lanza et a1 1986). Increased prostaglandin synthesis in gastric tissue has been thought to be responsible for the antiulcer effect of paracetamol (Van Kolfschoten et a1 1981, 1983.…”