Field experiments conducted in 1992 and 1993 in Georgia evaluated the response of the peanut cultivars Florunner, Georgia Runner, Goldkist GK 7, NC 7, NC-VII, Southern Runner, Sunrunner, and AgraTech VC-I to AC263,222 applied early-postemergence (EPOST) at 71 g ha'. Visual injury, which was less than 13%, was independent of cultivar, and injury was not evident on any cultivar midseason. AC 263,222 slightly reduced canopy width consistently on all cultivars. The only significant effect on percentage fancy pods, medium, No.1, sound splits, damaged, and other kernels was the main effect of cultivar. There was a significant cultivar, AC 263,222, and cultivar-by-AC 263,222 effect on extra large kernels (ELK) and jumbo kernel percentages. Southern Runner and NC-Vll had Significantlylower percentage jumbo and ELK, respectively when treated with AC 263,222. In addition, Florunner and Sunrunner also had numerically less percentage jumbo kernels. Reductions in percentages of ELK and jumbo were probably the result of AC 263,222-induced maturity delays. However, these reductions were not reflected in peanut yields. The occurence oflate and early leaf spot, tomato spotted wilt virus (TSWV),and southern stem rot was independent of both cultivar and AC 263,222.