Effect of parathyroid hormone on energy metabolism ofskeletal muscle

Baczyński, R; Massry, Shaul G.; Magott, M; El-Belbessi, Sami; Kohan, Ricardo; Brautbar, Nachman

doi:10.1038/ki.1985.190

Cited by 158 publications

(92 citation statements)

References 23 publications

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“…Besides bone, several lines of evidence indicate that skeletal muscle is also a target organ for PTH. It has been documented that excessive PTH affects the bioenergetics of skeletal muscle, impairing energy production, transfer and utilization (Baczynski et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

Resting energy expenditure and its determinants in hemodialysis patients

et al. 2006

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Objective: Chronic kidney disease is associated with several metabolic disturbances that can affect energy metabolism. As resting energy expenditure (REE) is scarcely investigated in patients on hemodialysis (HD) therapy, we aimed to evaluate the REE and its determinants in HD patients. Design: Cross-sectional study. Setting: Dialysis Unit of the Nephrology Division, Federal University of São Paulo, Brazil. Subjects: The study included 55 patients (28 male, 41.4712.6 years old) undergoing HD therapy thrice weekly for at least 2 months, and 55 healthy individuals pair matched for age and gender. Subjects underwent fasting blood tests, as well as nutritional assessment, and the REE was assessed by indirect calorimetry. Results: REE of HD patients was similar to that of pair-matched controls (13797272 and 14407259 kcal/day, respectively), even when adjusted for fat-free mass (P ¼ 0.24). REE of HD patients correlated positively with fat-free mass (r ¼ 0.74; Po0.001) and body mass index (r ¼ 0.37; Po0.01), and negatively with dialysis adequacy (r ¼ À0.46; Po0.001). No significant univariate correlation was found between REE and age, dialysis vintage, serum creatinine, urea, albumin, bicarbonate, parathyroid hormone (PTH) or high-sensitivity C-reactive protein (CRP). In the multiple linear regression analysis, using REE as dependent variable, the final model showed that besides the well-recognized determinants of REE such as fat-free mass and age, PTH and CRP were the independent determinants of REE in HD patients (R 2 ¼ 0.64).

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Section: Discussionmentioning

confidence: 99%

Resting energy expenditure and its determinants in hemodialysis patients

et al. 2006

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“…Serum levels of 1.25(OH) 2 D 3 have been associated with decreased muscle strength, lower endurance [8,9,10,11,12], reduced functional mobility [13,14], and atrophy of fast-twitch muscle fibers [35]. Also, 1.25(OH) 2 D 3 is an effective treatment of the iPTH-related decrease of energy metabolism in skeletal muscle and proteolysis of muscle proteins [36,37,38]. Low 1.25(OH) 2 D 3 serum Fig.…”

Section: Discussionmentioning

confidence: 99%

A new significant and independent risk factor for falls in elderly men and women: a low creatinine clearance of less than 65�ml/min

et al. 2004

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Objectives: Because impaired renal function is detrimental for the conversion of calcidiol to calcitriol (D-hormone) and since D-hormone analogues have been shown to decrease the risk of falls, we investigated whether creatinine clearance (CrCl) is associated with the number of fallers and falls in elderly men and women. Methods: Within a randomized controlled study, we observed for 36 weeks 186 placebo-treated community-dwelling elderly men and women over 70, in an attempt to determine the influence of baseline CrCl on calcitropic hormone serum levels, as well as the influence of baseline CrCl on the number of fallers and falls over time. With the help of questionnaires, we regularly assessed fall incidence and frequency. The risk of falls and the risk of becoming a faller were assessed in multivariate-controlled logistic regression models according to a cutoff value of the CrCl set at 65 ml/min. Results: At baseline, serum levels of 1.25(OH) 2 D 3 and iPTH were, in multivariate-controlled analyses, significantly associated with CrCl (p<0.0001, p=0.001, respectively), whereas serum levels of 25(OH)D 3 were not associated with CrCl. Below a CrCl of 65 ml/min, 1.25(OH) 2 D 3 serum levels steadily declined. We therefore chose a CrCl of 65 ml/min as cutoff for further analyses. During the 36 weeks of observation, elderly people with a CrCl of <65 ml/min had, in multivariate controlled analyses, compared with elderly with a CrCl of ‡65 ml/min, a significantly higher incidence of number of fallers (25/70 vs 21/116; OR=4.01; 95% CI, 1.48-10.98; p=0.006), and a significantly higher incidence of falls (28/70 vs 23/ 116; OR=3.68; 95% CI, 1.38-9.82; p=0.009). Conclusions: For the first time we showed that in a communitydwelling population of elderly men and women, a CrCl of less than 65 ml/min is a significant and independent risk factor for fallers and falls.

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“…39,40 In peripheral tissue this increase in intracellular calcium inhibits insulin stimulated glucose uptake and causes insulin resistance. 41,42 There is evidence that hypophosphatemia decreases insulin sensitivity 43 and that phosphate supplementation improves glucose tolerance. Phosphate is involved in the energy balance and ATP generation.…”

Section: Discussionmentioning

confidence: 99%

Hyperparathyroidism and New Onset Diabetes After Renal Transplantation

Ivarsson¹,

Clyne²,

Almquist³

et al. 2014

Transplantation Proceedings

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Hyperparathyroidism and new onset diabetes after renal transplantation.Ivarsson, Kerstin; Clyne, Naomi; Almquist, Martin; Akaberi, Shahriar General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. (21) AbstractHyperparathyroidism and New Onset Diabetes after Renal TransplantationBackground: Secondary hyperparathyroidism (sHPT) persists after renal transplantation in a

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Effect of parathyroid hormone on energy metabolism ofskeletal muscle

Cited by 158 publications

References 23 publications

Resting energy expenditure and its determinants in hemodialysis patients

Resting energy expenditure and its determinants in hemodialysis patients

A new significant and independent risk factor for falls in elderly men and women: a low creatinine clearance of less than 65�ml/min

Hyperparathyroidism and New Onset Diabetes After Renal Transplantation

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