Effect of Parecoxib Sodium Preemptive Analgesia on the Recovery Period of General Anesthesia in Patients Undergoing Glioma Resection

Abstract

Objective. To investigate the effect of parecoxib sodium preemptive analgesia on postoperative complications and postoperative recovery of patients undergoing glioma resection. Methods. A total of 200 eligible patients with low-grade gliomas in the functional brain area scheduled for an awake craniotomy between January 2017 and December 2020 were reviewed. The subjects were divided into two groups: the study group (n = 100) given dexmedetomidine plus parecoxib sodium for pre-emptive analgesia 30 minutes preoperatively, and the control group (n = 100) receiving dexmedetomidine alone. Venous blood was collected before surgery, at the time of postoperative recovery, and 24 hours after operation, mean artery pressure (MAP) and heart rate (HR) were recorded during surgery. Sedation satisfaction, agitation rate, numerical pain score (NRS), postoperative complications, minimental state examination (MMSE) scores, quality of life (QoL) scores, and incidence of adverse events were also investigated after the surgery. Results. There were no significant differences in operation time, awakening time, intraoperative awakening time, and extubation time between the two groups ( P > 0.05 ). Compared with the control group, the ΔMAP (7.26 ± 2.21 versus 5.78 ± 2.36 mmHg) and the ΔHR (11.35 ± 3.66 versus 8.84 ± 2.47 beats/min) were significantly lower in the study group ( P < 0.05 ). Compared with the control group, the satisfaction was higher and agitation rate was lower in the study group ( P < 0.05 ). The incidence of intracranial infection and pulmonary infection decreased after operation ( P < 0.05 ). The NRS of the study group was remarkably lower than the control group at 12 hours postoperatively Preoperative MMSE score and QoL score showed no statistical difference ( P > 0.05 ), while postoperative MMSE and QoL scores showed statistical difference ( P < 0.05 ). Conclusion. This study suggests that parecoxib sodium can significantly improve the level of sedation and analgesia in patients undergoing glioma resection, reduce the incidence of intracranial infection and pulmonary infection.

Efficacy of Cyclooxygenase-2 Inhibitors for Headache in Acute Brain Injury: A Systematic Review

“…Five studies assessed the e cacy of COXIBs for headache control in the intervention versus control groups [27,28,[30][31][32], and one study assessed two different pain regimens employing COXIBs, in both the intervention and control groups [29]. The speci c COXIBs used, dosing, frequency, timing, and routes of administration varied; parecoxib 40 mg IV was most frequently employed (n=264) [27,[29][30][31], followed by celecoxib (n=93) [32] and rofecoxib (n=14) [28]. Pain scores were reported as mean or median at different time points, from the immediate postoperative period (0 hours) up to 72 hours.…”

“…The initial search yielded a total of 3190 articles. Following the removal of duplicates, 2988 articles were screened, with 6 studies meeting eligibility criteria (Figure 1): four RCT [27][28][29][30] and two retrospective cohort studies [31,32]. All studies were conducted in neurosurgical patients (n=738), between 2006-2022.…”

“…In all studies, pain scores ranged between mild and moderate severity. Four studies noted decreased pain scores at overall time points for the intervention groups compared with control groups [28, 29,31,32], while one study only did so at one point in time (6 hours postoperative) [27]. Overall, pain scores dropped between 4-15%, with the largest shift observed from moderate to mild severity.…”

Intertransverse process block versus subcostal transversus abdominis plane block in patients undergoing laparscopic radical gastrectomy: A prospective randomized controlled trial

“…[26] Here, the afferent center of injurious stimulus was reduced in all patients via the administration of butorphanol and a non-steroidal anti-in ammatory drug (parecoxib sodium). [27] The mechanism of action of erector spinae plane block has been proposed to involve the analgesic and antiin ammatory effects of systemic absorbed local anesthetics. [28] There was a reasonable doubt as to whether ITPB possessed similar anti-in ammatory effects.…”

The analgesic effect of Preemptive multimodal analgesia in Direct Anterior Approach total hip arthroplasty：a randomized double-blind trial

“…All patients were given PENG at 30min after drug injection, followed by general anesthesia. Earlier research showed that oxycodone (1mg Kg − 1 ) and parecoxib (40mg) sodium as a single preoperative dose administered was no safety problems [15,[20][21][22]. All patients who received the DAA-THA were given general anesthesia by senior anesthesiologists and were performed by the senior doctors in the same group, the anesthesiologists and doctors with more than ten years of experience.…”