Objective. To investigate the effect of parecoxib sodium preemptive analgesia on postoperative complications and postoperative recovery of patients undergoing glioma resection. Methods. A total of 200 eligible patients with low-grade gliomas in the functional brain area scheduled for an awake craniotomy between January 2017 and December 2020 were reviewed. The subjects were divided into two groups: the study group (n = 100) given dexmedetomidine plus parecoxib sodium for pre-emptive analgesia 30 minutes preoperatively, and the control group (n = 100) receiving dexmedetomidine alone. Venous blood was collected before surgery, at the time of postoperative recovery, and 24 hours after operation, mean artery pressure (MAP) and heart rate (HR) were recorded during surgery. Sedation satisfaction, agitation rate, numerical pain score (NRS), postoperative complications, minimental state examination (MMSE) scores, quality of life (QoL) scores, and incidence of adverse events were also investigated after the surgery. Results. There were no significant differences in operation time, awakening time, intraoperative awakening time, and extubation time between the two groups ( P > 0.05 ). Compared with the control group, the ΔMAP (7.26 ± 2.21 versus 5.78 ± 2.36 mmHg) and the ΔHR (11.35 ± 3.66 versus 8.84 ± 2.47 beats/min) were significantly lower in the study group ( P < 0.05 ). Compared with the control group, the satisfaction was higher and agitation rate was lower in the study group ( P < 0.05 ). The incidence of intracranial infection and pulmonary infection decreased after operation ( P < 0.05 ). The NRS of the study group was remarkably lower than the control group at 12 hours postoperatively Preoperative MMSE score and QoL score showed no statistical difference ( P > 0.05 ), while postoperative MMSE and QoL scores showed statistical difference ( P < 0.05 ). Conclusion. This study suggests that parecoxib sodium can significantly improve the level of sedation and analgesia in patients undergoing glioma resection, reduce the incidence of intracranial infection and pulmonary infection.
Objective: To explore the influence of painless childbirth technique on the psychology of primipara. Methods: From July 2020 to June 2022, 108 parturients who received analgesic during delivery in Shaanxi Provincial People’s Hospital were selected as the research subjects (painless delivery group), and 92 parturients who gave birth naturally during the same period were selected as controls (natural delivery group). Psychological tests were performed on the patients. Results: The depression and anxiety scores of parturients in the natural delivery group were significantly higher than those in the painless delivery group (P < 0.05); 9.0% of the patients had coexisting anxiety and depression. Conclusion: The application of painless delivery techniques in obstetrics can improve the negative emotions experienced by primipara, improve their self-efficacy, and relieve their psychological pressure.
Background and Objective: Securing the airway in the surgery of maxillofacial disorders and traumas is fundamental during the operation. The present study aims to investigate the beneficial sedative effects of dexmedetomidine (DEX) in patients who underwent maxillofacial surgery with regional anesthesia compare to general anesthesia. Methods: Fifty patients, aged 20-45 years old, were randomly divided into two groups of regional anesthesia (RA) and general anesthesia (GA) (each n=25). The group RA received regional block with sedation (DEX: 1 µg/kg infused over 10 min followed by the maintenance dose of 0.5 µg/kg/h) and the group GA underwent general anesthesia (DEX: 0.1 µg/kg/min over 10 min followed by 0.4–0.7 µg/kg/h). Postoperative pain scores, anesthesia outcomes, hemodynamic parameters, the time of the post-anesthesia care unit (PACU) discharge and intra and postoperative complications were comparatively assessed in both groups. Results: The baseline characteristics of the patients (age, gender, BMI and ASA physical status) showed no differences between two groups (P>0.05). Although the duration of surgery and recovery time showed no differences between the groups, duration of anesthesia and extubation time was remarkably lower in the RA group than the GA group (P<0.01). Administration of nerve blocks demonstrated less pain and longer sleep time in the postoperative phase as compared to the GA group. Heart rate and mean arterial blood pressure were significantly less in the RA group at the end of the loading dose of DEX and incision time (P<0.05). SpO2, respiration rate and Ramsay sedation scale did not exhibit any significant differences between the two groups at all-time points (P>0.05). No significant differences were observed with regard to the adverse events between the two groups (P>0.05). Conclusions: Although our findings revealed that both methods are suitable and safe methods for maxillofacial surgery, the outcomes of anesthesia with regional block and sedation including less pain in the postoperative phase, shorter extubation time and earlier discharge from the PACU demonstrated that this method is more reliable for maxillofacial surgery. Further controlled studies are needed to compare the effectiveness and safety profiles of two RA and GA techniques and also to compare DEX with other anesthetic agents to achieve optimum outcomes in the maxillofacial surgeries.
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