Effect of parsley (Petroselinum crispum, Apiaceae) juice against cadmium neurotoxicity in albino mice (Mus Musculus)

Maodaa, Saleh N.; Allam, Ahmed A.; Ajarem, Jamaan S.; Abdel-Maksoud, Mostafa A.; Albasher, Gadah; Wang, Zun Yao

doi:10.1186/s12993-016-0090-3

Cited by 51 publications

(40 citation statements)

References 56 publications

(69 reference statements)

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“…In the motor cortex, cellular densities of astrocytes and neurons were decreased after inorganic mercury exposure ( Figures 8 , 9 ). Previous toxicological studies already indicate that the decrease in the number of both astrocytes and neurons is usually associated with functional damage observed in behavioral tests ( Akagi and Nishimura, 1991 ; Suzuki et al, 2004 ; Flores-Montoya et al, 2015 ; Maodaa et al, 2016 ). In addition, in vitro exposure to inorganic mercury causes cell death in human neurons and astrocytes ( Lohren et al, 2015 ).…”

Section: Discussionmentioning

confidence: 96%

Exposure to Inorganic Mercury Causes Oxidative Stress, Cell Death, and Functional Deficits in the Motor Cortex

Teixeira

Oliveira

Leão

et al. 2018

Front. Mol. Neurosci.

106

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Mercury is a toxic metal that can be found in the environment in three different forms – elemental, organic and inorganic. Inorganic mercury has a lower liposolubility, which results in a lower organism absorption and reduced passage through the blood–brain barrier. For this reason, exposure models that use inorganic mercury in rats in order to evaluate its effects on the central nervous system are rare, especially in adult subjects. This study investigated if a chronic exposure to low doses of mercury chloride (HgCl2), an inorganic form of mercury, is capable of promoting motor alterations and neurodegenerative in the motor cortex of adult rats. Forty animals were exposed to a dose of 0.375 mg/kg/day, for 45 days. They were then submitted to motor evaluation and euthanized to collect the motor cortex. Measurement of mercury deposited in the brain parenchyma, evaluation of oxidative balance, quantification of cellular cytotoxicity and apoptosis and density of mature neurons and astrocytes of the motor cortex were performed. It was observed that chronic exposure to inorganic mercury caused a decrease in balance and fine motor coordination, formation of mercury deposits and oxidative stress verified by the increase of lipoperoxidation and nitrite concentration and a decrease of the total antioxidant capacity. In addition, we found that this model of exposure to inorganic mercury caused cell death by cytotoxicity and induction of apoptosis with a decreased number of neurons and astrocytes in the motor cortex. Our results provide evidence that exposure to inorganic mercury in low doses, even in spite of its poor ability to cross biological barriers, is still capable of inducing motor deficits, cell death by cytotoxicity and apoptosis, and oxidative stress in the motor cortex of adult rats.

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Section: Discussionmentioning

confidence: 96%

Exposure to Inorganic Mercury Causes Oxidative Stress, Cell Death, and Functional Deficits in the Motor Cortex

Teixeira

Oliveira

Leão

et al. 2018

Front. Mol. Neurosci.

106

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“…In modern medicine, parsley has been exhibited antioxidant, immunosuppressant, cytoprotective, diuretic, antibacterial and antifungal activities [73]. It is one of the most used medicinal plants to treat renal diseases [74], antihyperlipidemic, antihyperglycemic [75], and anti-microbial [76] [77] [78]. Parsley has been used as antiurolithiasis, antiseptic of the urinary tract, diuretic, anti-dote, and anti-inflammatory in folklore and traditional medicines [73].…”

Section: Parsley (Petroselinum Crispum)mentioning

confidence: 99%

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Azab¹,

Albasha²,

Elsayed³

2017

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Nephrotoxicity is one of the most common kidney problems and occurs when the body is exposed to a drug or toxin. Natural sources of antioxidants may serve as a vital source of potentially useful new compounds for the development of an effective therapy to combat a variety of kidney problems. Natural antioxidants have a variety of biochemical actions such as inhibition of reactive oxygen species production, scavenging of free radicals. The present review aims to summarize the recent articles which studied some of the nephrotoxic agents, and alleviation of nephrotoxicity using of some natural products possessing antioxidant properties. Our review shows the oxidative damage and renal disorders induced in human and experimental animals by nephrotoxic agents such as gentamicin, alcohol, nicotine, adenine, glycerol, ethylene glycol, sodium nitrite, mercuric chloride, AlCl 3 , lead acetate, carbon tetrachloride (CCl 4 ), furosemide, carbendazim, diazinon, heat stress, and γ-radiation. Also, nephrotic disorders caused in diabetic rats, patients, cirrhotic ascetic patients, and ischemia-reperfusion. Administration of natural sources of antioxidants such as curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame attenuated both physiological and histopathological alterations induced in the kidney by the nephrotoxic agent and certain diseases. The nephroprotective effect of the former natural sources of antioxidants may be due to the enhancement of antioxidant activity and inhibition of tissue lipid peroxidation. It can be concluded that administration of curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame showed a remarkable kidney protection against nephrotoxic agents, and diseases induced renal dysfunctions in human and experimental animals. So, the present study recommended that the consumption of these natural sources of antioxidants may be useful for human exposure to nephrotoxic agents and patients who suffer from renal diseases.

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“…Tea, a potent antioxidant with metal chelating properties owing to its numerous hydroxyl groups [38,39] has been shown to have neuroprotective effects in a number of neuropathological conditions linked to excitotoxicity and oxidative stress [40]. A few studies have reported significant beneficial effects of plant extracts including tea against metal-induced neurotoxicity [19,41,42,43,44]. However, to the best of our knowledge, this is the first study to compare the protective effects of polyphenol rich tea (Camellia sinensis) and EDTA against Cdinduced neurotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Tea Against Cadmium Toxicity

Wachira

Areba

Ngure

et al. 2019

Bioactive Compounds in Health and Disease

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Background: Cadmium (Cd) is a common pollutant and potential neuro-toxicant to humans. The main treatment for heavy metal toxicity is chelation therapy which is however replete with grave side effects. This study was designed to determine the neuroprotective effects of extracts of the tea beverage on experimentally induced cadmium toxicity in the brain of rats. Cadmiumas CdCl2 was administered subcutaneously while tea was given orally.Methods: Healthy Wister rats were used to study the effects of co-administration of Cd and tea extracts on the brain. Cadmium was injected subcutaneously while tea was administered orally to the rats. Brain tissue from euthanized rats was assayed for Zinc Fingers and Homeoboxes Protein 1 (ZHX1), reduced glutathione (GSH), and lipid peroxidation markers Thiobarbituric Acid Reactive Substances (TBARS). Neurohistochemical and histopathological studies were also carried out on the brain tissues of the rats.Results: Cadmium significantly induced neuronal damage exhibited by a significant (p < 0.05) decrease in ZHX1 in the brain tissue, significant (p <0.05) increase in TBARS, as well as significant (p < 0.05) increase in GSH implying an impaired antioxidant defense system. Co-administration of Cd with black or green tea extracts resulted in a significant decrease in lipid peroxidation as well as maintenance of GSH and ZHX1. The neurohistochemical and histopathological studies in the brain of the rats indicated that the tea extracts significantly reduced CdCl2 toxicity and preserved the normal histological architecture of the brain tissues.Conclusion: This paper reports for the first time the efficacy of tea extracts in protecting rats from cadmium induced toxicity and disturbances of antioxidant defense system in the brain.Key words: Tea; flavonoids; Cadmium; neurotoxicity; Chelating agents.

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Effect of parsley (Petroselinum crispum, Apiaceae) juice against cadmium neurotoxicity in albino mice (Mus Musculus)

Cited by 51 publications

References 56 publications

Exposure to Inorganic Mercury Causes Oxidative Stress, Cell Death, and Functional Deficits in the Motor Cortex

Exposure to Inorganic Mercury Causes Oxidative Stress, Cell Death, and Functional Deficits in the Motor Cortex

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Neuroprotective Effects of Tea Against Cadmium Toxicity

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