Effect of partial hydrolyzates of casein and soybean protein on serum lipoproteins and fecal neutral steroids.

Tanaka, Chizuko; Nozaki, Yoshihisa

doi:10.3177/jnsv.29.439

Cited by 9 publications

(4 citation statements)

References 14 publications

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“…In our experiment, the excretion of neutral steroids to feces was increased and coprostanol occupied a large part of the steroids in rats fed soybean protein than in rats fed casein which seemed to be due to the difference of intestinal microbial flora between the soybean protein and casein diet groups (7). Although direct evidence has not been presented, it has been assumed that microbial conversion of cholesterol to less efficiently absorbable coprostanol could affect the sterol balance (8)(9)(10)(11).…”

mentioning

confidence: 79%

Effect of soybean protein on coprostanol production and cholesterol metabolism in cholesterol-fed rats.

Tanaka

Watanuki

Nozaki

1983

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effect of soybean protein on coprostanol production and cholesterol metabolism was studied in cholesterol-fed rats.Plasma cholesterol was decreased in the soybean protein diet group compared to the casein diet group. Although coprostanol was produced more in rats fed soybean protein than in those fed casein, no difference was observed in the levels of total neutral steroids at any part of the intestine.The activity of microbial conversion from cholesterol to coprostanol was evidently high in rats fed soybean protein.The total amount of neutral steroids excreted in feces had a tendency to increase. These data seem to indicate that the increase of the unabsorbed soybean protein causes the increase of intestinal coprostanol production.

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confidence: 79%

Effect of soybean protein on coprostanol production and cholesterol metabolism in cholesterol-fed rats.

Tanaka

Watanuki

Nozaki

1983

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…In rabbits, rats, and chicks, steroid adsorptive ability of proteolytic interme diates derived from dietary proteins is known as an important factor for steroid excretion (17,19,30,(32)(33)(34). It is likely, therefore, that digestion of casein and/or soy protein proceeds in somewhat different manners between rats and mice, so that the two proteins exert different effects on fecal steroid excretion in rats but not in mice.…”

Section: Discussionmentioning

confidence: 99%

The effect of dietary protein source on plasma cholesterol level and fecal steroid excretion in obese mice.

Yamashita

Hayashi

1990

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Both goldthioglucose (GTG)-treated and the genetically obese (C57BL/6J ob/ob) mice were fed semisynthetic diets containing either soy protein isolate (SPI) or casein as a protein source, or laboratory chow. In GTG-induced obese mice, the plasma cholesterol level corre lated positively with their body weight. The level was highest in mice fed high-fat diet, and lowest in ones fed laboratory chow. No difference was observed between SPI and casein groups whether the diet was low-fat or high-fat. Thus, in the GTG-treated mice, SPI did not have a hypocho lesterolemic effect while dietary fat had a hypercholesterolemic effect, and laboratory chow contained some component(s) which can lower the plasma cholesterol level. Both neutral and acidic steroid contents in feces of the SPI group were not different from those of the casein group, and both groups of mice excreted a smaller amount of steroids than mice fed laboratory chow. Results of essentially the same tendency were obtained with normal mice regarding the effects of SPI and casein, although the degree of hypercholesterolemia was lower in high-fat-fed normal mice than in similarly fed GTG-treated mice. These results strengthened the inverse correlation between the amount of fecal steroids and the plasma cholesterol level upon feeding various proteins, indicating that the former is one of the important factors that determine the latter. The ob/ob mice showed a marked hypercholesterolemia irrespective of the kind of diet. The amount of fecal steroids was highest in the laboratory chow group and lowest in the casein group. This indicates that some factor(s) other than fecal steroid excretion is dominantly responsible for their hyper cholesterolemia.

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“…animal protein, it has also been reported that a partial hydrolyzate of casein decreases the plasma cholesterol level more than intact casein does (9) . However, Huff et al showed that an enzymatic hydrolyzate of casein elevates serum choles terol levels in the rabbit to much the same extent as intact casein (11); this effect however, was not pronounced.…”

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confidence: 96%

Plasma Cholesterol-Suppressing Effect of Papain-Hydrolyzed Pork Meat in Rats Fed Hypercholesterolemic Diet.

Morimatsu¹,

Ito

Budijanto

et al. 1996

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effects of papain-hydrolyzed pork meat on plasma and liver cholesterol levels were studied in rats fed a cholesterol-enriched diet. In rats fed the low-molecular-weight fraction of papain-hydrolyzed pork meat, the plasma cholesterol concentration, more particularly the VLDL and LDL cholesterol concentrations, were significantly lower (p<0.01) than in the rats fed untreated pork meat or soybean protein. Feeding with this fraction rather than with untreated pork meat also led to a signifi cantly lower liver cholesterol concentration (p<0.01) and increased fecal excretion of neutral and acidic steroids. The low-molecular-weight frac tion contained peptides with molecular weights of 3,000 or less and had an amino acid composition similar to that of pork meat itself. This study suggests that peptides produced by papain-hydrolysis of pork meat have a hypocholesterolemic activity through their interference with the steroid absorption process.

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Effect of partial hydrolyzates of casein and soybean protein on serum lipoproteins and fecal neutral steroids.

Cited by 9 publications

References 14 publications

Effect of soybean protein on coprostanol production and cholesterol metabolism in cholesterol-fed rats.

Effect of soybean protein on coprostanol production and cholesterol metabolism in cholesterol-fed rats.

The effect of dietary protein source on plasma cholesterol level and fecal steroid excretion in obese mice.

Plasma Cholesterol-Suppressing Effect of Papain-Hydrolyzed Pork Meat in Rats Fed Hypercholesterolemic Diet.

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