Effect of Particle Size and Compression Force on Compaction Behavior and Derived Mathematical Parameters of Compressibility

Patel, Sarsvatkumar; Kaushal, Aditya Mohan; Bansal, Arvind K.

doi:10.1007/s11095-006-9129-8

Cited by 117 publications

(77 citation statements)

References 32 publications

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“…Elastic recovery is the reversible part of deformation and is indicative of poor interparticulate bonding (14,31). In this study, it was observed that the elastic recovery of each particle-size fraction increased with increasing compression pressure, which was already observed by Patel et al (14).…”

Section: Compactibility and Elastic Recoverysupporting

confidence: 79%

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A compressibility and compactibility study of real tableting mixtures: the effect of granule particle size

Šantl¹,

Ilić²,

Vrečer³

et al. 2012

Acta Pharmaceutica

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The original size of granules is an important property, which can affect the compression and compaction properties of aggregates as well as the pharmaceutical quality of prepared tablets (1). Effects of the initial particle size on the compression behavior of tableting mixtures have been studied by many authors (2-14), but only a few published studies have specifically reported a relationship between granule/pellet size and compression behavior (1,(15)(16)(17). Based on these studies, it seems that there is no simple rule regarding the impact of granule size on tablet strength. It has been reported that a reduction in granule size corresponds to an increase in tablet strength (16, 17) but contrary to this, some studies have confirmed that tablet strength increases with an increase in gran- This study investigates the effect of particle size on the compression characteristics of wet-(fluid-bed granulation -FBG) and dry-granulated (slugging -DGS) tableting mixtures. Particle-size distribution, flowability, compressibility, using the Heckel and Walker model, compactibility and elastic recovery as well as friability and disintegration were determined and compared between the two particle size fractions (180-400 µm, 400-710 µm) and initial unsieved mixtures. The results showed that the particle size of granules had no effect on the compressibility of the FBG and DGS mixtures, due to the high fragmenting nature of the formulation used in this study. On the other hand, compactibility was particle size dependent, as larger-sized fractions showed higher crushing strength, lower friability, and lower elastic recovery. This was attributed to increased fragmentation of larger particles, allowing stronger bonding between uncontaminated surface areas. As a result of better rearrangement of particles, both initial tableting mixtures showed lower compressibility and lower compactibility compared to their sieved fractions.

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Section: Compactibility and Elastic Recoverysupporting

confidence: 79%

“…For example, it has been shown that the fragmentation propensity of a substance under load increases with its particle size (3,14). For this reason, a change in the mean particle size may alter the predominant consolidation mechanism.…”

mentioning

confidence: 99%

A compressibility and compactibility study of real tableting mixtures: the effect of granule particle size

Šantl¹,

Ilić²,

Vrečer³

et al. 2012

Acta Pharmaceutica

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“…The constant "a" is related to the total volume reduction for the powder bed (compressibility index) and the constant "b" is related to the resistant forces (friction/cohesion) to compression. 9) Particle Size Samples were fractionated on a ROTAP sieve shaker (RX29, W.S. Tyler Co., Mentor, OH, U.S.A.) using stainless steel 420, 250, 180,125 105, 75 mm sieves, stacked together in the order written (Fisher Scientific Co., Pittsburgh, PA, U.S.A.).…”

Section: Methodsmentioning

confidence: 99%

Assessment of Processing and Polymorphic Form Effect on the Powder and Tableting Properties of Microcrystalline Celluloses I and II

et al. 2011

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Microcrystalline cellulose I (MCCI) is an excipient used as a diluent, disintegrant, glidant and binder for the production of pharmaceutical tablets. In this work, microcrystalline cellulose II (MCCII) was obtained from cotton fibers by basic treatment with 7.5 N NaOH followed by an acid hydrolysis. MCCI and MCCII materials were processed by wet granulation, dry granulation and spray drying. Either the polymorphic form or processing had no effects on the particle morphology or particle size. However, MCCII powders had a higher porosity, less packing tendency, degree of crystallinity, degree of polymerization and density, but a faster disintegration than MCCI. The tensile strength of MCCI was highly affected by the wet and dry granulation processes. Most of the resulting powder and tableting properties were dependent on the polymorphic form of cellulose, rather than on the processing employed.

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“…However, in 1982 a study by McKenna and McCafferty [17] revealed that during their calculation of yield pressure, particle size was irrelevant for lactose. Another study by Patel et al [18] found that the yield pressure of paracetamol was dependant on particle size, where increasing particle size resulted in higher yield pressure values. Recent studies have suggested that as the yield pressure is derived from the density pressure relationship this value is actually an indication of powder densification rate that may be effected by particle size [19].…”

Section: Introductionmentioning

confidence: 98%

A Modern Approach to the Heckel Equation: The Effect of Compaction Pressure on the Yield Pressure of Ibuprofen and its Sodium Salt

Hooper¹,

Fc²,

Mitchell³

et al. 2016

J Nanomed Nanotechnol

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Effect of Particle Size and Compression Force on Compaction Behavior and Derived Mathematical Parameters of Compressibility

Cited by 117 publications

References 32 publications

A compressibility and compactibility study of real tableting mixtures: the effect of granule particle size

A compressibility and compactibility study of real tableting mixtures: the effect of granule particle size

Assessment of Processing and Polymorphic Form Effect on the Powder and Tableting Properties of Microcrystalline Celluloses I and II

A Modern Approach to the Heckel Equation: The Effect of Compaction Pressure on the Yield Pressure of Ibuprofen and its Sodium Salt

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