Effect of Particulate Air Pollution on Lung Function in Adult and Pediatric Subjects in a Seattle Panel Study

Trenga, Carol A.; Sullivan, Jeffrey; Schildcrout, Jonathan S.; Shepherd, Kristen; Shapiro, Gail G.; Liu, L.-J. Sally; Kaufman, Joel D.; Koenig, Jane Q.

doi:10.1378/chest.129.6.1614

Cited by 142 publications

(121 citation statements)

References 30 publications

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“…Significant associations were mainly observed among symptomatic subjects. In this population, indoor particulate matter concentration has been related to a decrease in lung function, in particular among children with asthma [117][118][119][120] and, to a lesser extent, to an increased risk of asthmatic and bronchitis-like symptoms [121,122]. In a cohort of 150 asthmatic children, PM2.5 and PM2.5-10 concentrations, assessed three times every 3 months, were positively associated with the incidence rate of several respiratory symptoms, including cough, asthma symptoms and wheezing [121].…”

Section: Particulate Mattermentioning

confidence: 99%

Respiratory health and indoor air pollutants based on quantitative exposure assessments

et al. 2012

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We reviewed the main epidemiological studies that evaluate the respiratory effects of indoor air pollutants quantitatively in industrialised countries. Consistent results support short-term (aggravation) and, although more rarely, long-term (prevalence augmentation) effects on asthma, chronic bronchitis and chronic obstructive pulmonary disease (COPD) in indoor settings with poor air quality. Environmental tobacco smoke is one of the most important risks for respiratory symptoms and diseases worldwide. The evidence is also reliable for indoor nitrogen dioxide and particulate matter, which have been associated with asthma, bronchitis and COPD. Whereas formaldehyde and volatile organic compounds seem to be the main pollutants in indoor settings, relevant papers on their respiratory effects are still scarce, and limited to asthma and bronchitis. Moulds have been associated with an increased risk of asthma and COPD. Contradictory results have been found between endotoxins and asthma. The role of phthalates, persistent organic pollutants and flame retardants in respiratory diseases remains to be established. Results from rural areas of industrialised countries indicate that exposure to some indoor bio-contaminants might be protective in early life, while it is associated with adverse respiratory adverse effects in adulthood. Studies focusing on indoor air pollutants should be developed to better understand their involvement in the inception and aggravation of respiratory diseases.

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Section: Particulate Mattermentioning

confidence: 99%

Respiratory health and indoor air pollutants based on quantitative exposure assessments

et al. 2012

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“…(Simons et al, 2006) Differences in exposure to indoor as well as outdoor PM may be partially responsible for increased inner-city asthma burden While the evidence for the effect of ambient PM is substantial, there is now also growing evidence for the effect of indoor PM on asthma health. For example, small panel studies in children have found that exposure to elevated indoor PM concentrations is associated with lower lung function (Koenig et al, 2005;Trenga et al, 2006). While these latter studies of the effect of indoor PM on asthma have not focused on racial and ethnic minorities, this evidence suggests that indoor PM may have harmful effects on the respiratory health of young children generally.…”

Section: Introductionmentioning

confidence: 99%

Common household activities are associated with elevated particulate matter concentrations in bedrooms of inner-city Baltimore pre-school children

McCormack

Breysse

Hansel

et al. 2008

Environmental Research

108

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Asthma disproportionately affects inner-city, minority children in the U.S. Outdoor pollutant concentrations, including particulate matter (PM), are higher in inner-cities and contribute to childhood asthma morbidity. Although children spend the majority of time indoors, indoor PM exposures have been less extensively characterized. There is a public health imperative to characterize indoor sources of PM within this vulnerable population to enable effective intervention strategies. In the present study, we sought to identify determinants of indoor PM in homes of Baltimore inner-city pre-school children.Children ages 2-6 (n=300) who were predominantly African-American (90%) and from lower socioeconomic backgrounds were enrolled. Integrated PM 2.5 and PM 10 air sampling was conducted over a 3-day period in the children's bedrooms and at a central monitoring site while caregivers completed daily activity diaries. Homes of pre-school children in inner-city Baltimore had indoor PM concentrations that were twice as high as simultaneous outdoor concentrations. The mean indoor PM 2.5 and PM 10 concentrations were 39.5±34.5 μg/m 3 and 56.2±44.8 μg/m 3 , compared to the simultaneously measured ambient PM 2.5 and PM 10 (15.6±6.9 and 21.8±9.53 μg/m 3 , respectively). Common modifiable household activities, especially smoking and sweeping, contributed significantly to higher indoor PM, as did ambient PM concentrations. Open windows were associated with significantly lower indoor PM. Further investigation of the health effects of indoor PM exposure is warranted, as are studies to evaluate the efficacy of PM reduction strategies on asthma health of inner-city children.

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“…Recent studies regarding the relationship between air pollution and health effects have shown short-term changes in respiratory symptoms or respiratory health indicators in two susceptible groups: children and patients with respiratory disease. [1][2][3][4] These reports provide evidence of the sensitive and subtle adverse health effects of low-level exposure to air pollution.…”

Section: Introductionmentioning

confidence: 91%

“…1,2 Decreases in lung function related to PM 10 exposure have been reported. 3,4 Lung function measurement is a specific objective method of monitoring respiratory health and may detect subtle respiratory effects of air pollution. Indeed, measurements of pulmonary function may be a more sensitive way to evaluate the effect of air pollution on the lung health than relying on the appearance of respiratory symptoms or disease.…”

Section: Introductionmentioning

confidence: 99%

Lag effect of particulate air pollution on lung function in children

Min¹,

Min²,

Cho³

et al. 2008

Pediatric Pulmonology

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Summary. We assessed the relationship between particle air pollution and changes in lung function in children as measured by spirometry over time. Data were collected from air pollution and family health examinations of 181 subjects, aged 9-19 years, in a Korean community. The children performed lung function tests, and their height and weight were measured. Their parents responded to an interview regarding the children's history of disease. Data on air pollution were obtained from the Environmental Management Corporation, which is part of the Korean Ministry of the Environment. We found evidence that the declines in forced vital capacity (FVC) and forced expiratory volume in 1 sec (FEV 1 ) were significantly associated with the PM 10 concentration for 37-60 hr preceding the lung function tests. The associations were consistent in the two-pollutant models. Our findings suggest that exposure to PM 10 may increase the risk of adverse health effects in children with respiratory symptoms or diseases.

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Effect of Particulate Air Pollution on Lung Function in Adult and Pediatric Subjects in a Seattle Panel Study

Cited by 142 publications

References 30 publications

Respiratory health and indoor air pollutants based on quantitative exposure assessments

Respiratory health and indoor air pollutants based on quantitative exposure assessments

Common household activities are associated with elevated particulate matter concentrations in bedrooms of inner-city Baltimore pre-school children

Lag effect of particulate air pollution on lung function in children

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