Effect of Paspalum scrobiculatum extract on acutely disturbed schizophrenic patients

Deo, Veena; Bhide, N K

doi:10.1007/bf00411197

Cited by 2 publications

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“…As the dose of the extract in the experiment in man was about 5 times that which produced tranquillization in acutely disturbed schizophrenics after 3 to 4 days of administration (Deo & Bhide, 1961), it is possible that the effects experienced were not due entirely to " suggestion." However, the final assessment of the extract will be possible only after further chemical and clinical investigations.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Study and Fractionation of Paspalum Scrobiculatum Extract

Bhide

1962

British Journal of Pharmacology and Chemotherapy

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The dried ethanol extract of the husk of the grain of Paspalum scrobiculatum produced tranquillization and tremors in various species of animals. It potentiated the effect of hexobarbitone in mice, produced hypothermia in mice and rats and enhanced leptazol toxicity in rats. Amphetamine group-toxicity in mice increased after injecting the extract or an emulsion containing a similar quantity of olive oil. Vomiting in pigeons and decrease of morphine rage in cats were noted. Diminution of carotid occlusion reflex and hypotension were observed in anaesthetized dogs. Tremors and sleep were experienced by a human volunteer after taking the extract orally. Stability of the extract under different conditions was studied in dogs. Fractions of the extract, resolved by solvent separation and column chromatography, were tested in dogs for tranquillization and tremors.

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Section: Discussionmentioning

confidence: 99%