Effect of Pentagastrin on the Motor Activity of the Dilated and Nondilated Sigmoid and Rectum in Chagas’ Disease

Meneghelli, U. G.; Godoy, Renato Alves de; Oliveira, Ricardo Brandt de; Santos, João; Dantas, Roberto Oliveira; Troncon, L E A

doi:10.1159/000198945

Cited by 25 publications

(22 citation statements)

References 11 publications

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“…Previous studies in Chagas disease patients have evidenced colonic hypomotility defined by low basal motility index and low wave frequency in the rectosigmoid, and impairment of the anorectal inhibitory reflex. 16,17 The results of these previous studies agree only partially with our findings: we observed that 28 of 69 (40.6%) patients with Chagas disease showed manometric evidence of anorectal motor dysfunction, but an abnormal anorectal inhibitory reflex was only confirmed in one asymptomatic patient.…”

Section: Discussionsupporting

confidence: 73%

Assessment of Rectocolonic Morphology and Function in Patients with Chagas Disease in Barcelona (Spain)

Salvador¹,

Mego²,

Sánchez-Montalvà³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. The aim of this study was to determine the relationship between colonic symptoms, radiological abnormalities, and anorectal dysfunction in patients with Chagas disease. We performed a cross-sectional study of untreated patients diagnosed with Chagas disease. All patients were evaluated clinically (by a questionnaire for colonic symptoms based on Rome III criteria) and underwent a barium enema and anorectal manometry. A control group of patients with functional constipation and without Chagas disease was included in the study. Overall, 69 patients were included in the study: 42 patients were asymptomatic and 27 patients had abdominal symptoms according to Rome III criteria. Anorectal manometry showed a higher proportion of abnormalities in symptomatic patients than in asymptomatic ones (73% versus 21%, respectively; P 0.0001).

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Section: Discussionsupporting

confidence: 73%

Assessment of Rectocolonic Morphology and Function in Patients with Chagas Disease in Barcelona (Spain)

Salvador¹,

Mego²,

Sánchez-Montalvà³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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“…Degenerative changes in the intestinal wall together with a decrease in the number of nervous elements, and particularly neurons, in the region of the myenteric plexus have been confirmed. Such changes take place in the course of Chaga's disease, in which Trypanosoma cruzi parasites destroy the ENS, causing chronic constipation and leading to serious pathological widening of the large intestine [18,[20][21][22]. Taking into account the lack of nervous elements in the solid cancerous tumour destroying the wall of the intestine, as confirmed in this investigation, together with the results of investigations of other pathologies of the intestine, where destruction of the ENS leads to gradual constipation and widening of the colon, similar pathologic changes may be indicated as taking place also in the course of carcinoma of the large intestine.…”

Section: Discussionmentioning

confidence: 99%

Morphological changes in the enteric nervous system caused by carcinoma of the human large intestine.

Godlewski

2010

Folia Histochem Cytobiol.

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Abstract:The innervations of the large intestine is responsible for it peristalsis and contractilibility. Investigations of the enteric nervous system in many colon diseases have revealed changes in this structure. No study has been carried out on morphological changes of the enteric nervous system in the human large intestine with carcinoma. The aim of this study was to investigate potential changes in the structure of the enteric neurons in patients with sigmoid and rectal cancer. Material for the study was obtained from patients undergoing operations due to carcinoma of the sigmoid colon and rectum. Microscopic observation of the cancerous tumor of the human large intestine revealed changes in the enteric nervous system innervating this part of the gastrointestinal tract. In the region of the enteric plexuses located close to the tumour, disruption of their correct placement and structure was observed. The changes also consisted of the disappearance of neurons and nerve fibers forming these plexuses. In the solid cancerous tumour, elements of the enteric nervous system were not present. Destruction of the enteric nervous system in the course of carcinoma of the large intestine may cause disruption of proper intestinal function and may be responsible for part of symptoms which the patients suffer.

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“…Patients with megacolon (Fig. 7A) present long-term waves and hy- percontraction of muscle fibers, and these alterations are not detected in control individuals; the sigmoid colons of chagasic patients show low mobility with higher wave frequency rates than those of nonchagasic individuals (278). These abnormalities are attributed to neuron loss (Fig.…”

Section: Clinical and Pathological Presentations Of Chagas' Diseasementioning

confidence: 96%

Pathogenesis of Chagas' Disease: Parasite Persistence and Autoimmunity

et al. 2011

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SUMMARY Acute Trypanosoma cruzi infections can be asymptomatic, but chronically infected individuals can die of Chagas' disease. The transfer of the parasite mitochondrial kinetoplast DNA (kDNA) minicircle to the genome of chagasic patients can explain the pathogenesis of the disease; in cases of Chagas' disease with evident cardiomyopathy, the kDNA minicircles integrate mainly into retrotransposons at several chromosomes, but the minicircles are also detected in coding regions of genes that regulate cell growth, differentiation, and immune responses. An accurate evaluation of the role played by the genotype alterations in the autoimmune rejection of self-tissues in Chagas' disease is achieved with the cross-kingdom chicken model system, which is refractory to T. cruzi infections. The inoculation of T. cruzi into embryonated eggs prior to incubation generates parasite-free chicks, which retain the kDNA minicircle sequence mainly in the macrochromosome coding genes. Crossbreeding transfers the kDNA mutations to the chicken progeny. The kDNA-mutated chickens develop severe cardiomyopathy in adult life and die of heart failure. The phenotyping of the lesions revealed that cytotoxic CD45, CD8 + γδ, and CD8α + T lymphocytes carry out the rejection of the chicken heart. These results suggest that the inflammatory cardiomyopathy of Chagas' disease is a genetically driven autoimmune disease.

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Effect of Pentagastrin on the Motor Activity of the Dilated and Nondilated Sigmoid and Rectum in Chagas’ Disease

Cited by 25 publications

References 11 publications

Assessment of Rectocolonic Morphology and Function in Patients with Chagas Disease in Barcelona (Spain)

Assessment of Rectocolonic Morphology and Function in Patients with Chagas Disease in Barcelona (Spain)

Morphological changes in the enteric nervous system caused by carcinoma of the human large intestine.

Pathogenesis of Chagas' Disease: Parasite Persistence and Autoimmunity

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